Microbiology

Short-Term Instantaneous Prophylaxis and Efficient Treatment Against SARS-CoV-2 in hACE2 Mice Conferred by an Intranasal Nanobody (Nb22)

1. Xilin Wu
2. Yaxing Wang
3. Lin Cheng
4. Fengfeng Ni
5. Linjing Zhu
6. Sen Ma
7. Bilian Huang
8. Mengmeng Ji
9. Huimin Hu
10. Yuncheng Li
11. Shijie Xu
12. Haixia Shi
13. Doudou Zhang
14. Linshuo Liu
15. Waqas Nawaz
16. Qinxue Hu
17. Sheng Ye
18. Yalan Liu
19. Zhiwei Wu

Reviewed by ScreenIT

Wildlife in Cameroon harbor diverse coronaviruses, including many closely related to human coronavirus 229E

1. Nkom F Ntumvi
2. Valantine Ngum Ndze
3. Amethyst Gillis
4. Joseph Le Doux Diffo
5. Ubald Tamoufe
6. Jean-Michel Takuo
7. Moctar M M Mouiche
8. Julius Nwobegahay
9. Matthew LeBreton
10. Anne W Rimoin
11. Bradley S Schneider
12. Corina Monagin
13. David J McIver
14. Sanjit Roy
15. James A Ayukekbong
16. Karen E Saylors
17. Damien O Joly
18. Nathan D Wolfe
19. Edward M Rubin
20. Christian E Lange

Reviewed by ScreenIT

Genomic evidence for divergent co-infections of SARS-CoV-2 lineages

1. Hang-Yu Zhou
2. Ye-Xiao Cheng
3. Lin Xu
4. Jia-Ying Li
5. Chen-Yue Tao
6. Cheng-Yang Ji
7. Na Han
8. Rong Yang
9. Yaling Li
10. Aiping Wu

Reviewed by ScreenIT

Optimization of Single-Dose VSV-Based COVID-19 Vaccination in Hamsters

1. Kyle L. O’Donnell
2. Chad S. Clancy
3. Amanda J. Griffin
4. Kyle Shifflett
5. Tylisha Gourdine
6. Tina Thomas
7. Carrie M. Long
8. Wakako Furuyama
9. Andrea Marzi

Reviewed by ScreenIT

Azacytidine targeting SARS-CoV-2 viral RNA as a potential treatment for COVID-19

1. Xian Lin
2. Xianliang Ke
3. Xiaoqin Jian
4. Lin Xia
5. Yang Yang
6. Tianying Zhang
7. Hualong Xiong
8. Binghai Zhao
9. Wen Liu
10. Quanjiao Chen
11. Chong Tang

Reviewed by ScreenIT

Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism

1. See-Yeun Ting
2. Kaitlyn D LaCourse
3. Hannah E Ledvina
4. Rutan Zhang
5. Matthew C Radey
6. Hemantha D Kulasekara
7. Rahul Somavanshi
8. Savannah K Bertolli
9. Larry A Gallagher
10. Jennifer Kim
11. Kelsi M Penewit
12. Stephen J Salipante
13. Libin Xu
14. S Brook Peterson
15. Joseph D Mougous

• Curated by eLife

  Evaluation Summary:

  Using a genome wide screen, the authors identify novel pathways that protect Pseudomonas aeruginosa against Type-6 secretion-mediated by other bacterial species. Importantly these pathways each protect against specific effectors. As an example, the authors further show that one factor Arc3B protects against phospholipase activity by antagonizing the production of lysophospholipids induced by phospholipase-type effectors. These findings uncover potentially conserved and unsuspected bacterial-defense pathways.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife, PREreview

Distinct neutralizing kinetics and magnitudes elicited by different SARS-CoV-2 variant spikes

1. Yang Liu
2. Jianying Liu
3. Jing Zou
4. Ping Ren
5. Scott C. Weaver
6. Xuping Xie
7. Pei-Yong Shi

Reviewed by ScreenIT

Characterization of SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.618 on cell entry, host range, and sensitivity to convalescent plasma and ACE2 decoy receptor

1. Wenlin Ren
2. Xiaohui Ju
3. Mingli Gong
4. Jun Lan
5. Yanying Yu
6. Quanxin Long
7. Yu Zhang
8. Jin Zhong
9. Guocai Zhong
10. Xinquan Wang
11. Ailong Huang
12. Rong Zhang
13. Qiang Ding

Reviewed by ScreenIT

Epistasis at the SARS-CoV-2 RBD Interface and the Propitiously Boring Implications for Vaccine Escape

1. Nash D. Rochman
2. Guilhem Faure
3. Yuri I. Wolf
4. Peter L. Freddolino
5. Feng Zhang
6. Eugene V. Koonin

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Gut bacterial aggregates as living gels

1. Brandon H Schlomann
2. Raghuveer Parthasarathy

• Curated by eLife

  Evaluation Summary:

  This manuscript provides an innovative merging of biophysical models with imaging data to explain the physical structure of microbial communities in the gut of zebrafish. Using imaging data to examine cluster sizes for eight different bacterial strains in the larval zebrafish gut, the authors report a common family of size distributions and show that these distributions arise naturally from a simple biophysical model of aggregation that tends to condense the system to a single massive cluster, reminiscent of gel formation observed in non-living systems. Within-host microbial dynamics represent an area of tremendous interest, as the microbiome is increasingly recognized to play a role in host physiology. This work contributes to a new perspective by elucidating physical mechanisms driving spatial segregation of these communities, opening the door to future studies that incorporate traditional genomic and microbiological insight with the physical and mechanical dynamics of microbial communities in living hosts.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife