Microbiology

  1. Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies

    1. Myriam Scherer
    2. Clarissa Read
    3. Gregor Neusser
    4. Christine Kranz
    5. Anna K Kuderna
    6. Regina Müller
    7. Florian Full
    8. Sonja Wörz
    9. Anna Reichel
    10. Eva-Maria Schilling
    11. Paul Walther
    12. Thomas Stamminger

    • Curated by eLife

      Evaluation Summary:

      This work has potential broad interest to both virologists and cell biologists interested in the regulatory functions of promyelocytic leukaemia nuclear bodies (PML-NBs). The authors use a combination of imaging techniques to identify PML, the principal scaffolding protein of PML-NBs, to form a variety of different structures in response to viral infection, immune stimulation, and DNA damage. Thestudy identifies PML to restrict the replication of human cytomegalovirus (HCMV) at multiple stages of infection through the formation of alternate PML-scaffold assemblies.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. ZRC3308 Monoclonal Antibody Cocktail Shows Protective Efficacy in Syrian Hamsters against SARS-CoV-2 Infection

    1. Pragya D. Yadav
    2. Sanjeev Kumar Mendiratta
    3. Sreelekshmy Mohandas
    4. Arun K. Singh
    5. Priya Abraham
    6. Anita Shete
    7. Sanjay Bandyopadhyay
    8. Sanjay Kumar
    9. Aashini Parikh
    10. Pankaj Kalita
    11. Vibhuti Sharma
    12. Hardik Pandya
    13. Chirag G. Patel
    14. Mihir Patel
    15. Swagat Soni
    16. Suresh Giri
    17. Mukul Jain

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

    1. Shelly J. Robertson
    2. Olivia Bedard
    3. Kristin L. McNally
    4. Carl Shaia
    5. Chad S. Clancy
    6. Matthew Lewis
    7. Rebecca M. Broeckel
    8. Abhilash I. Chiramel
    9. Jeffrey G. Shannon
    10. Gail L. Sturdevant
    11. Rebecca Rosenke
    12. Sarah L. Anzick
    13. Elvira Forte
    14. Christoph Preuss
    15. Candice N. Baker
    16. Jeffrey M. Harder
    17. Catherine Brunton
    18. Steven Munger
    19. Daniel P. Bruno
    20. Justin B. Lack
    21. Jacqueline M. Leung
    22. Amirhossein Shamsaddini
    23. Paul Gardina
    24. Daniel E. Sturdevant
    25. Jian Sun
    26. Craig Martens
    27. Steven M. Holland
    28. Nadia A. Rosenthal
    29. Sonja M. Best

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. A novel hamster model of SARS-CoV-2 respiratory infection using a pseudotyped virus

    1. Hiroshi Yamada
    2. So-Ichiro Sasaki
    3. Hideki Tani
    4. Mayu Somekawa
    5. Hitoshi Kawasuji
    6. Yumiko Saga
    7. Yoshihiro Yoshida
    8. Yoshihiro Yamamoto
    9. Yoshihiro Hayakawa
    10. Yoshitomo Morinaga

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Virophages and retrotransposons colonize the genomes of a heterotrophic flagellate

    1. Thomas Hackl
    2. Sarah Duponchel
    3. Karina Barenhoff
    4. Alexa Weinmann
    5. Matthias G Fischer

    • Curated by eLife

      Evaluation Summary:

      Approaching the search of novel viruses while in an endogenized stage, rather than as free virions, the study by Hackl et al. reveals a large diversity of complete and fragmented virophage genomes - termed EMALEs- scattered throughout the genomes of four strains of the marine protist Cafeteria. Given that the activation of the integrated virophage mavirus during infection by the giant virus, CroV, has been shown to have a protective effect on the Cafeteria population, this study provides a tantalizing window into the traces of virophage-giant virus¬-protist interactions in the marine environment. Given the enormous diversity of virophages and giant viruses that have been found in metagenomes with no known hosts, this study is a step towards deciphering the biology of these viruses.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  6. Humoral immune responses against seasonal coronaviruses predict efficiency of SARS-CoV-2 spike targeting, FcγR activation, and corresponding COVID-19 disease severity

    1. Jose L. Garrido
    2. Matias Medina
    3. Felipe Bravo
    4. Sarah McGee
    5. Francisco Fuentes
    6. Mario Calvo
    7. James W. Bowman
    8. Christopher D. Bahl
    9. Maria Inés Barría
    10. Rebecca A. Brachman
    11. Raymond A. Alvarez

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice

    1. Alexandra Schäfer
    2. David R. Martinez
    3. John J. Won
    4. Fernando R. Moreira
    5. Ariane J. Brown
    6. Kendra L. Gully
    7. Rao Kalla
    8. Kwon Chun
    9. Venice Du Pont
    10. Darius Babusis
    11. Jennifer Tang
    12. Eisuke Murakami
    13. Raju Subramanian
    14. Kimberly T Barrett
    15. Blake J. Bleier
    16. Roy Bannister
    17. Joy Y. Feng
    18. John P. Bilello
    19. Tomas Cihlar
    20. Richard L. Mackman
    21. Stephanie A. Montgomery
    22. Ralph S. Baric
    23. Timothy P. Sheahan

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. BNT162b2-Elicited Neutralization of Delta Plus, Lambda, and Other Variants

    1. Jianying Liu
    2. Yang Liu
    3. Hongjie Xia
    4. Jing Zou
    5. Scott C. Weaver
    6. Kena A. Swanson
    7. Hui Cai
    8. Mark Cutler
    9. David Cooper
    10. Alexander Muik
    11. Kathrin U. Jansen
    12. Ugur Sahin
    13. Xuping Xie
    14. Philip R. Dormitzer
    15. Pei-Yong Shi

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques

    1. Jingyou Yu
    2. Natalie D. Collins
    3. Noe B. Mercado
    4. Katherine McMahan
    5. Abishek Chandrashekar
    6. Jinyan Liu
    7. Tochi Anioke
    8. Aiquan Chang
    9. Victoria M. Giffin
    10. David L. Hope
    11. Daniel Sellers
    12. Felix Nampanya
    13. Sarah Gardner
    14. Julia Barrett
    15. Huahua Wan
    16. Jason Velasco
    17. Elyse Teow
    18. Anthony Cook
    19. Alex Van Ry
    20. Laurent Pessaint
    21. Hanne Andersen
    22. Mark G. Lewis
    23. Christian Hofer
    24. Donald S. Burke
    25. Erica K. Barkei
    26. Hannah A. D. King
    27. Caroline Subra
    28. Diane Bolton
    29. Kayvon Modjarrad
    30. Nelson L. Michael
    31. Dan H. Barouch

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Pharmacological perturbation of intracellular dynamics as a SARS-CoV-2 antiviral strategy

    1. William Bakhache
    2. Emma Partiot
    3. Vincent Lucansky
    4. Yonis Bare
    5. Boris Bonaventure
    6. Caroline Goujon
    7. Cédric Bories
    8. Maika S. Deffieu
    9. Raphael Gaudin

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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