Microbiology

Lung-selective Cas13d-based nanotherapy inhibits lethal SARS-CoV-2 infection by targeting host protease Ctsl

1. Zhifen Cui
2. Cong Zeng
3. Furong Huang
4. Fuwen Yuan
5. Jingyue Yan
6. Yue Zhao
7. Jiaoti Huang
8. Herman F. Staats
9. Jeffrey I. Everitt
10. Gregory D. Sempowski
11. Hongyan Wang
12. Yizhou Dong
13. Shan-Lu Liu
14. Qianben Wang

Reviewed by ScreenIT

B.1.617.3 SARS CoV-2 spike E156G/Δ157-158 mutations contribute to reduced neutralization sensitivity and increased infectivity

1. Tarun Mishra
2. Garima Joshi
3. Atul Kumar
4. Rishikesh Dalavi
5. Pankaj Pandey
6. Sanjeev Shukla
7. Ram Kumar Mishra
8. Ajit Chande

Reviewed by ScreenIT

In vitro activity of cysteamine against SARS-CoV-2 variants

1. Jess Thoene
2. Robert F. Gavin
3. Aaron Towne
4. Lauren Wattay
5. Maria Grazia Ferrari
6. Jennifer Navarrete
7. Ranajit Pal

Reviewed by ScreenIT

The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

1. Xiaotian Tang
2. Yongguo Cao
3. Gunjan Arora
4. Jesse Hwang
5. Andaleeb Sajid
6. Courtney L Brown
7. Sameet Mehta
8. Alejandro Marín-López
9. Yu-Min Chuang
10. Ming-Jie Wu
11. Hongwei Ma
12. Utpal Pal
13. Sukanya Narasimhan
14. Erol Fikrig

• Curated by eLife

  Evaluation Summary:

  This article identifies a new metabolic pathway in ticks that Borrelia burgdorferi, the agent of Lyme disease, requires for survival. The authors show that the adiponectin receptor (ISARL) is upregulated after a blood meal and find that the tick complement C1q-like protein (C1QL3) is an ISARL ligand whose knockdown impairs spirochete colonization.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Comparison of Plaque Size, Thermal Stability, and Replication Rate among SARS-CoV-2 Variants of Concern

1. Gi Uk Jeong
2. Gun Young Yoon
3. Hyun Woo Moon
4. Wooseong Lee
5. Insu Hwang
6. Haesoo Kim
7. Kyun-Do Kim
8. Chonsaeng Kim
9. Dae-Gyun Ahn
10. Bum-Tae Kim
11. Seong-Jun Kim
12. Young-Chan Kwon

Reviewed by ScreenIT

SARS-CoV-2 Variants of Concern Infect the Respiratory Tract and Induce Inflammatory Response in Wild-Type Laboratory Mice

1. Shannon Stone
2. Hussin Alwan Rothan
3. Janhavi Prasad Natekar
4. Pratima Kumari
5. Shaligram Sharma
6. Heather Pathak
7. Komal Arora
8. Tabassum Tasnim Auroni
9. Mukesh Kumar

Reviewed by ScreenIT

Ad26.COV2.S Prevents SARS-CoV-2 Induced Pathways of Inflammation and Thrombosis in Hamsters

1. Malika Aid
2. Samuel J. Vidal
3. Cesar Piedra-Mora
4. Sarah Ducat
5. Chi N. Chan
6. Stephen Bondoc
7. Alessandro Colarusso
8. Carly E. Starke
9. Michael Nekorchuk
10. Kathleen Busman-Sahay
11. Jacob D. Estes
12. Amanda J. Martinot
13. Dan H. Barouch

Reviewed by ScreenIT

Nasopharyngeal Microbiota as an early severity biomarker in COVID-19 hospitalised patients

1. Maria Paz Ventero
2. Oscar Moreno-Perez
3. Carmen Molina-Pardines
4. Andreu Paytuví-Gallart
5. Vicente Boix
6. Isabel Escribano
7. Irene Galan
8. Pilar González-delaAleja
9. Mario López-Pérez
10. Rosario Sánchez-Martínez
11. Esperanza Merino
12. Juan Carlos Rodríguez

Reviewed by ScreenIT

Milk casein prevents inactivation effect of black tea galloylated theaflavins on SARS-CoV-2 in vitro

1. Eriko Ohgitani
2. Masaharu Shin-Ya
3. Masaki Ichitani
4. Makoto Kobayashi
5. Takanobu Takihara
6. Motoki Saito
7. Hitoshi Kinugasa
8. Osam Mazda

Reviewed by ScreenIT

Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

1. Seyi Falekun
2. Jaime Sepulveda
3. Yasaman Jami-Alahmadi
4. Hahnbeom Park
5. James A Wohlschlegel
6. Paul A Sigala

• Curated by eLife

  Evaluation Summary:

  This study defines the role of a divergent mitochondrial-localized isoform of a FASII acyl carrier protein (mACP) in the malaria parasite, Plasmodium falciparum. In contrast to the situation in other eukaryotes, mACP is not involved in fatty acid biosynthesis, but is primarily involved in stabilizing proteins involved in mitochondrial Fe-S complex formation. Analysis of mACP function in these protists indicates that ACP acquired a role in Fe-S complex formation early in eukaryotic evolution and highlights additional components of the Plasmodium respiratory chain that are important for viability.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife