Microbiology

  1. The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

    1. Rana Abdelnabi
    2. Caroline S. Foo
    3. Dirk Jochmans
    4. Laura Vangeel
    5. Steven De Jonghe
    6. Patrick Augustijns
    7. Raf Mols
    8. Birgit Weynand
    9. Thanaporn Wattanakul
    10. Richard M. Hoglund
    11. Joel Tarning
    12. Charles E. Mowbray
    13. Peter Sjö
    14. Fanny Escudié
    15. Ivan Scandale
    16. Eric Chatelain
    17. Johan Neyts

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. SARS-CoV-2 variants of concern remain dependent on IFITM2 for efficient replication in human lung cells

    1. Rayhane Nchioua
    2. Annika Schundner
    3. Dorota Kmiec
    4. Caterina Prelli-Bozzo
    5. Fabian Zech
    6. Lennart Koepke
    7. Alexander Graf
    8. Stefan Krebs
    9. Helmut Blum
    10. Manfred Frick
    11. Konstantin M. J. Sparrer
    12. Frank Kirchhoff

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Clinically observed deletions in SARS‐CoV‐2 Nsp1 affect its stability and ability to inhibit translation

    1. Pravin Kumar
    2. Erin Schexnaydre
    3. Karim Rafie
    4. Tatsuaki Kurata
    5. Ilya Terenin
    6. Vasili Hauryliuk
    7. Lars‐Anders Carlson

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants

    1. Katherine E. Zarn
    2. Sierra A. Jaramillo
    3. Anthony R. Zapata
    4. Nathan E. Stone
    5. Ashley N. Jones
    6. Haley E. Nunnally
    7. Erik W. Settles
    8. Ken Ng
    9. Paul S. Keim
    10. Steen Knudsen
    11. Patricia M. Nuijten
    12. Aloys S. L. Tijsma
    13. Christopher T. French

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. mRNA vaccines induce rapid antibody responses in mice

    1. Makda S. Gebre
    2. Susanne Rauch
    3. Nicole Roth
    4. Janina Gergen
    5. Jingyou Yu
    6. Xiaowen Liu
    7. Andrew C. Cole
    8. Stefan O. Mueller
    9. Benjamin Petsch
    10. Dan H. Barouch

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Coronavirus RNA Synthesis Takes Place within Membrane-Bound Sites

    1. Nicole Doyle
    2. Jennifer Simpson
    3. Philippa C. Hawes
    4. Helena J. Maier

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. The P681H mutation in the Spike glycoprotein confers Type I interferon resistance in the SARS-CoV-2 alpha (B.1.1.7) variant

    1. Maria Jose Lista
    2. Helena Winstone
    3. Harry D Wilson
    4. Adam Dyer
    5. Suzanne Pickering
    6. Rui Pedro Galao
    7. Giuditta De Lorenzo
    8. Vanessa M. Cowton
    9. Wilhelm Furnon
    10. Nicolas Suarez
    11. Richard Orton
    12. Massimo Palmarini
    13. Arvind H. Patel
    14. Luke Snell
    15. Gaia Nebbia
    16. Chad Swanson
    17. Stuart J D Neil

    Reviewed by ScreenIT

    1 evaluationAppears in 2 listsLatest version Latest activity

  8. Variations in Cell Surface ACE2 Levels Alter Direct Binding of SARS-CoV-2 Spike Protein and Viral Infectivity: Implications for Measuring Spike Protein Interactions with Animal ACE2 Orthologs

    1. Soheila Kazemi
    2. Alberto Domingo López-Muñoz
    3. Jaroslav Hollý
    4. Ling Jin
    5. Jonathan W. Yewdell
    6. Brian P. Dolan

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress

    1. Yong Fu
    2. Kevin M Brown
    3. Nathaniel G Jones
    4. Silvia NJ Moreno
    5. L David Sibley

    • Curated by eLife

      Evaluation Summary:

      The cyst-forming stages of Toxoplasma gondii that perpetuate chonic infections in more than a quarter of the world's human population exist in a metabolically quiescent state. This study provides evidence that metabolic quiescence in bradyzoite cysts is associated with a profound dampening of calcium signalling, including uptake and release from internal stores, which is reversed following bradyzoite egress and exposure to exogenous calcium and carbon sources.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  10. Updated vaccine protects from infection with SARS-CoV-2 variants, prevents transmission and is immunogenic against Omicron in hamsters

    1. Sapna Sharma
    2. Thomas Vercruysse
    3. Lorena Sanchez-Felipe
    4. Winnie Kerstens
    5. Madina Rasulova
    6. Rana Abdelnabi
    7. Caroline S Foo
    8. Viktor Lemmens
    9. Dominique Van Looveren
    10. Piet Maes
    11. Guy Baele
    12. Birgit Weynand
    13. Philippe Lemey
    14. Johan Neyts
    15. Hendrik Jan Thibaut
    16. Kai Dallmeier

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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