Microbiology

  1. The adenosine analogue prodrug ATV006 is orally bioavailable and has potent preclinical efficacy against SARS-CoV-2 and its variants

    1. Liu Cao
    2. Yingjun Li
    3. Sidi Yang
    4. Guanguan Li
    5. Qifan Zhou
    6. Jing Sun
    7. Tiefeng Xu
    8. Yujian Yang
    9. Tiaozhen Zhu
    10. Siyao Huang
    11. Yanxi Ji
    12. Feng Cong
    13. Yinzhu Luo
    14. Yujun Zhu
    15. Hemi Luan
    16. Huan Zhang
    17. Jingdiao Chen
    18. Xue Liu
    19. Ping Wang
    20. Yang Yu
    21. Fan Xing
    22. Bixia Ke
    23. Huanying Zheng
    24. Xiaoling Deng
    25. Wenyong Zhang
    26. Chun-Mei Li
    27. Yu Zhang
    28. Jincun Zhao
    29. Xumu Zhang
    30. Deyin Guo

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

    1. Allison J. Greaney
    2. Tyler N. Starr
    3. Rachel T. Eguia
    4. Andrea N. Loes
    5. Khadija Khan
    6. Farina Karim
    7. Sandile Cele
    8. John E. Bowen
    9. Jennifer K. Logue
    10. Davide Corti
    11. David Veesler
    12. Helen Y. Chu
    13. Alex Sigal
    14. Jesse D. Bloom

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Clp protease and antisense RNA jointly regulate the global regulator CarD to mediate mycobacterial starvation response

    1. Xinfeng Li
    2. Fang Chen
    3. Xiaoyu Liu
    4. Jinfeng Xiao
    5. Binda T Andongma
    6. Qing Tang
    7. Xiaojian Cao
    8. Shan-Ho Chou
    9. Michael Y Galperin
    10. Jin He

    • Curated by eLife

      Evaluation Summary:

      CarD is an RNA polymerase interacting protein that is essential for mycobacterial viability, the levels of which are important for controlling gene expression in mycobacteria during various stress conditions. This study reports two mechanisms that regulate levels of CarD under stress conditions, including starvation. The authors report that CarD levels are tightly regulated and that there was a dramatic decrease in the levels of CarD when cells switched from the nutrient-rich to the starvation condition. They discovered two synergistic mechanisms that led to this dramatic decrease in CarD. The first is SigF-dependent induction of antisense RNA of CarD (AscarD), which inhibits CarD translation and a second mechanism involving Clp protease-mediated degradation of intracellular CarD. The work will be of interest to researchers studying non-coding RNAs, microbial gene expression, physiology and stress response.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. SARS-CoV-2 variants exhibit increased kinetic stability of open spike conformations as an evolutionary strategy

    1. Ziwei Yang
    2. Yang Han
    3. Shilei Ding
    4. Andrés Finzi
    5. Walther Mothes
    6. Maolin Lu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

    1. Wael Kamel
    2. Vincenzo Ruscica
    3. Azman Embarc-Buh
    4. Zaydah R. de Laurent
    5. Manuel Garcia-Moreno
    6. Yana Demyanenko
    7. Richard J. Orton
    8. Marko Noerenberg
    9. Meghana Madhusudhan
    10. Louisa Iselin
    11. Aino I. Järvelin
    12. Maximilian Hannan
    13. Eduardo Kitano
    14. Samantha Moore
    15. Andres Merits
    16. Ilan Davis
    17. Shabaz Mohammed
    18. Alfredo Castello

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

    1. Wei Qiao
    2. Hui En Lau
    3. Huizhi Xie
    4. Vincent Kwok-Man Poon
    5. Chris Chung-Sing Chan
    6. Hin Chu
    7. Shuofeng Yuan
    8. Terrence Tsz-Tai Yuen
    9. Kenn Ka-Heng Chik
    10. Jessica Oi-Ling Tsang
    11. Chris Chun-Yiu Chan
    12. Jian-Piao Cai
    13. Cuiting Luo
    14. Kwok-Yung Yuen
    15. Kenneth Man-Chee Cheung
    16. Jasper Fuk-Woo Chan
    17. Kelvin Wai-Kwok Yeung

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19

    1. David Schult
    2. Sandra Reitmeier
    3. Plamena Koyumdzhieva
    4. Tobias Lahmer
    5. Moritz Middelhoff
    6. Johanna Erber
    7. Jochen Schneider
    8. Juliane Kager
    9. Marina Frolova
    10. Julia Horstmann
    11. Lisa Fricke
    12. Katja Steiger
    13. Moritz Jesinghaus
    14. Klaus-Peter Janssen
    15. Ulrike Protzer
    16. Klaus Neuhaus
    17. Roland M. Schmid
    18. Dirk Haller
    19. Michael Quante

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. An intestinally secreted host factor promotes microsporidia invasion of C. elegans

    1. Hala Tamim El Jarkass
    2. Calvin Mok
    3. Michael R Schertzberg
    4. Andrew G Fraser
    5. Emily R Troemel
    6. Aaron W Reinke

    • Curated by eLife

      Evaluation Summary:

      Despite the broad impact of microsporidia on diverse animals, host factors involved in their invasion have not been characterized. The present study identifies a previously uncharacterized intestinal factor (AAIM-1) that is necessary for efficient infection of early larval stages of C. elegans. The secreted factor has a minor effect mediating resistance to pathogenic bacteria, suggesting more general impact on the susceptibility of the worm to diverse pathogens.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  9. SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

    1. Biao Zhou
    2. Runhong Zhou
    3. Jasper Fuk-Woo Chan
    4. Jianwei Zeng
    5. Qi Zhang
    6. Shuofeng Yuan
    7. Li Liu
    8. Rémy Robinot
    9. Sisi Shan
    10. Jiwan Ge
    11. Hugo Yat-Hei Kwong
    12. Dongyan Zhou
    13. Haoran Xu
    14. Chris Chung-Sing Chan
    15. Vincent Kwok-Man Poon
    16. Hin Chu
    17. Ming Yue
    18. Ka-Yi Kwan
    19. Chun-Yin Chan
    20. Na Liu
    21. Chris Chun-Yiu Chan
    22. Kenn Ka-Heng Chik
    23. Zhenglong Du
    24. Ka-Kit Au
    25. Haode Huang
    26. Hiu-On Man
    27. Jianli Cao
    28. Cun Li
    29. Ziyi Wang
    30. Jie Zhou
    31. Youqiang Song
    32. Man-Lung Yeung
    33. Kelvin Kai-Wang To
    34. David D. Ho
    35. Lisa A. Chakrabarti
    36. Xinquan Wang
    37. Linqi Zhang
    38. Kwok-Yung Yuen
    39. Zhiwei Chen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques

    1. Amit A. Upadhyay
    2. Timothy N. Hoang
    3. Maria Pino
    4. Arun K. Boddapati
    5. Elise G. Viox
    6. Michelle Y.H. Lee
    7. Jacqueline Corry
    8. Zachary Strongin
    9. David A. Cowan
    10. Elizabeth N. Beagle
    11. Tristan R. Horton
    12. Sydney Hamilton
    13. Hadj Aoued
    14. Justin L. Harper
    15. Kevin Nguyen
    16. Kathryn L. Pellegrini
    17. Gregory K. Tharp
    18. Anne Piantadosi
    19. Rebecca D. Levit
    20. Rama R. Amara
    21. Simon M. Barratt-Boyes
    22. Susan P. Ribeiro
    23. Rafick P. Sekaly
    24. Thomas H. Vanderford
    25. Raymond F. Schinazi
    26. Mirko Paiardini
    27. Steven E. Bosinger

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
Previous Page 134 of 252 Next