Microbiology

  1. Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype

    1. Xiaofeng Dong
    2. Hannah Goldswain
    3. Rebekah Penrice-Randal
    4. Ghada T. Shawli
    5. Tessa Prince
    6. Maia Kavanagh Williamson
    7. Nadine Randle
    8. Benjamin Jones
    9. Francisco J Salguero
    10. Julia A. Tree
    11. Yper Hall
    12. Catherine Hartley
    13. Maximilian Erdmann
    14. James Bazire
    15. Tuksin Jearanaiwitayakul
    16. ISARIC4C investigators
    17. Malcolm G. Semple
    18. Peter J. M. Openshaw
    19. J. Kenneth Baille
    20. Stevan R. Emmett
    21. Paul Digard
    22. David A. Matthews
    23. Lance Turtle
    24. Alistair Darby
    25. Andrew D. Davidson
    26. Miles W. Carroll
    27. Julian A. Hiscox

    Reviewed by ScreenIT

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  2. Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants

    1. Kang Wang
    2. Zijing Jia
    3. Linilin Bao
    4. Lei Wang
    5. Lei Cao
    6. Hang Chi
    7. Yaling Hu
    8. Qianqian Li
    9. Yunjiao Zhou
    10. Yinan Jiang
    11. Qianhui Zhu
    12. Yongqiang Deng
    13. Pan Liu
    14. Nan Wang
    15. Lin Wang
    16. Min Liu
    17. Yurong Li
    18. Boling Zhu
    19. Kaiyue Fan
    20. Wangjun Fu
    21. Peng Yang
    22. Xinran Pei
    23. Zhen Cui
    24. Lili Qin
    25. Pingju Ge
    26. Jiajing Wu
    27. Shuo Liu
    28. Yiding Chen
    29. Weijin Huang
    30. Qiao Wang
    31. Cheng-Feng Qin
    32. Youchun Wang
    33. Chuan Qin
    34. Xiangxi Wang

    Reviewed by ScreenIT

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  3. Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies

    1. Xun Wang
    2. Xiaoyu Zhao
    3. Jieyu Song
    4. Jing Wu
    5. Yuqi Zhu
    6. Minghui Li
    7. Yuchen Cui
    8. Yanjia Chen
    9. Lulu Yang
    10. Jun Liu
    11. Huanzhang Zhu
    12. Shibo Jiang
    13. Pengfei Wang

    Reviewed by ScreenIT

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  4. An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants

    1. Xiaojing Chi
    2. Xinhui Zhang
    3. Shengnan Pan
    4. Yanying Yu
    5. Yujin Shi
    6. Tianli Lin
    7. Huarui Duan
    8. Xiuying Liu
    9. Wenfang Chen
    10. Xuehua Yang
    11. Lan Chen
    12. Xiaoqian Dong
    13. Lili Ren
    14. Qiang Ding
    15. Jianwei Wang
    16. Wei Yang

    Reviewed by ScreenIT

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  5. Convalescence from prototype SARS-CoV-2 protects Syrian hamsters from disease caused by the Omicron variant

    1. Kathryn A. Ryan
    2. Robert J. Watson
    3. Kevin R. Bewley
    4. Christopher Burton
    5. Oliver Carnell
    6. Breeze E. Cavell
    7. Amy Challis
    8. Naomi S. Coombes
    9. Kirsty Emery
    10. Rachel Fell
    11. Susan A. Fotheringham
    12. Karen E. Gooch
    13. Kathryn Gowan
    14. Alastair Handley
    15. Debbie J. Harris
    16. Richard Humphreys
    17. Rachel Johnson
    18. Daniel Knott
    19. Sian Lister
    20. Daniel Morley
    21. Didier Ngabo
    22. Karen L. Osman
    23. Jemma Paterson
    24. Elizabeth J. Penn
    25. Steven T. Pullan
    26. Kevin S. Richards
    27. Imam Shaik
    28. Sian Summers
    29. Stephen R. Thomas
    30. Thomas Weldon
    31. Nathan R. Wiblin
    32. Richard Vipond
    33. Bassam Hallis
    34. Simon G. P. Funnell
    35. Yper Hall

    Reviewed by ScreenIT

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  6. Engineered ACE2 counteracts vaccine-evading SARS-CoV-2 Omicron variant

    1. Nariko Ikemura
    2. Shunta Taminishi
    3. Tohru Inaba
    4. Takao Arimori
    5. Daisuke Motooka
    6. Kazutaka Katoh
    7. Yuhei Kirita
    8. Yusuke Higuchi
    9. Songling Li
    10. Tatsuya Suzuki
    11. Yumi Itoh
    12. Yuki Ozaki
    13. Shota Nakamura
    14. Satoaki Matoba
    15. Daron M Standley
    16. Toru Okamoto
    17. Junichi Takagi
    18. Atsushi Hoshino

    Reviewed by ScreenIT

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  7. Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening

    1. Tomohisa Tanaka
    2. Akatsuki Saito
    3. Tatsuya Suzuki
    4. Yoichi Miyamoto
    5. Kazuo Takayama
    6. Toru Okamoto
    7. Kohji Moriishi

    Reviewed by ScreenIT

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  8. Number and proportion of P. falciparum gametocytes vary from acute infection to chronic parasite carriage despite unaltered sexual commitment rate

    1. Hannah van Dijk
    2. Martin Kampmann
    3. Nathalia F Lima
    4. Michael Gabel
    5. Usama Dabbas
    6. Safiatou Doumbo
    7. Hamidou Cisse
    8. Shanping Li
    9. Myriam Jeninga
    10. Richard Thomson-Luque
    11. Didier Doumtabe
    12. Michaela Petter
    13. Kassoum Kayentao
    14. Aissata Ongoiba
    15. Teun Bousema
    16. Peter D Crompton
    17. Boubacar Traore
    18. Frederik Graw
    19. Silvia Portugal

    • Curated by eLife

      Evaluation Summary:

      The work evaluates the production of P. falciparum sexual stage parasites in blood samples from asymptomatic parasite carriers through the dry season and symptomatic malaria patients in the wet season. Sexual stage parasites are required for malaria transmission via mosquito, but historically their low levels in peripheral blood have limited analysis. The work here monitored asexual and sexual stage parasitemia and found that the relative expression of early gametocyte genes, including ap2-g, is similar in samples from asymptomatic and asymptotic individuals. The data was used to model gametocyte availability from the initial symptomatic infection through the chronic phase and advances the understanding of factors that contribute to malaria transmission.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-week interval between doses

    1. Debashree Chatterjee
    2. Alexandra Tauzin
    3. Lorie Marchitto
    4. Shang Yu Gong
    5. Marianne Boutin
    6. Catherine Bourassa
    7. Guillaume Beaudoin-Bussières
    8. Yuxia Bo
    9. Shilei Ding
    10. Annemarie Laumaea
    11. Dani Vézina
    12. Josée Perreault
    13. Laurie Gokool
    14. Chantal Morrisseau
    15. Pascale Arlotto
    16. Éric Fournier
    17. Aurélie Guilbault
    18. Benjamin Delisle
    19. Inès Levade
    20. Guillaume Goyette
    21. Gabrielle Gendron-Lepage
    22. Halima Medjahed
    23. Gaston De Serres
    24. Cécile Tremblay
    25. Valérie Martel-Laferrière
    26. Daniel E. Kaufmann
    27. Renée Bazin
    28. Jérémie Prévost
    29. Sandrine Moreira
    30. Jonathan Richard
    31. Marceline Côté
    32. Andrés Finzi

    Reviewed by ScreenIT

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  10. Construction of a potent pan-vaccine based on the evolutionary tendency of SARS-CoV-2 spike protein

    1. Yongliang Zhao
    2. Wenjia Ni
    3. Simeng Liang
    4. Lianghui Dong
    5. Min Xiang
    6. Zeng Cai
    7. Danping Niu
    8. Qiuhan Zhang
    9. Dehe Wang
    10. Yucheng Zheng
    11. Zhen Zhang
    12. Dan Zhou
    13. Wenhua Guo
    14. Yongbing Pan
    15. Xiaoli Wu
    16. Yimin Yang
    17. Zhaofei Jing
    18. Yongzhong Jiang
    19. SARS-CoV-2 Vaccine Task Force Group
    20. Yu Chen
    21. Huan Yan
    22. Yu Zhou
    23. Ke Xu
    24. Ke Lan

    Reviewed by ScreenIT

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