Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro
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SciScore for 10.1101/2022.01.10.475377: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Reconstituted nasal epithelium - MucilAir™: Human nasal epithelial cells were obtained from patients undergoing polypectomy, experimental procedures were explained in full, and all subjects provided informed consent. Sex as a biological variable not detected. Randomization not detected. Blinding Compounds were selected using available data from primary screens using various cell lines (Vero E6, HeLa-ACE2, Calu-3) and organoids and were obtained blinded as 10 mM stock solution in dimethyl sulfoxide (DMSO). Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Vero E6 cells modified to constitutively express the … SciScore for 10.1101/2022.01.10.475377: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Reconstituted nasal epithelium - MucilAir™: Human nasal epithelial cells were obtained from patients undergoing polypectomy, experimental procedures were explained in full, and all subjects provided informed consent. Sex as a biological variable not detected. Randomization not detected. Blinding Compounds were selected using available data from primary screens using various cell lines (Vero E6, HeLa-ACE2, Calu-3) and organoids and were obtained blinded as 10 mM stock solution in dimethyl sulfoxide (DMSO). Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Vero E6 cells modified to constitutively express the serine protease TMPRSS2 (35) were obtained from the Centre for AIDS Reagents (National Institute for Biological Standards and Control) and were incubated for 3 days at 37°C, 5% CO2 and >85% rH prior to CPE determination by crystal violet staining. Vero E6suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04262921 Recruiting French COVID Cohort Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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