Microbiology

Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

1. Hang Li
2. Shengwei Ji
3. Nanang R Ariefta
4. Eloiza May S Galon
5. Shimaa AES El-Sayed
6. Thom Do
7. Lijun Jia
8. Miako Sakaguchi
9. Masahito Asada
10. Yoshifumi Nishikawa
11. Xin Qin
12. Mingming Liu
13. Xuenan Xuan

• Curated by eLife

  eLife Assessment

  This study presents valuable findings with practical and theoretical implications for drug discovery, particularly in the context of repurposing cipargamin CIP for the treatment of Babesia spp. The evidence is solid with the methods, data, and analyses broadly supporting the claims. The paper will be of great interest to scientists in drug discovery, computational biology, and microbiology.

Reviewed by eLife

Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC

1. Ryusei Yoshida
2. Kazuma Korogi
3. Qinfei Wu
4. Shogo Ozaki
5. Tsutomu Katayama

• Curated by eLife

  eLife Assessment

  This manuscript reports findings of fundamental significance on how bacteria might load helicase for DNA replication when normal DnaA-based loading pathway is defective. It provides convincing genetic and biochemical evidence that helicase loading at the E. coli oriC is not (as previously assumed) exclusively performed by the DnaA initiator protein but can also be executed by PriC (whether this occurs specifically at oriC has not been addressed in vivo). This is a significant step forward in our understanding of bacterial replication initiation.

Reviewed by eLife

Electromagnetic waves destabilize the SARS-CoV-2 Spike protein and reduce SARS-CoV-2 Virus-Like Particle (SC2-VLP) infectivity

1. Skyler Granatir
2. Francisco M. Acosta
3. Christina Pantoja
4. Johann Tailor
5. Angus Fuori
6. Bill Dower
7. Henry Marr
8. Peter W. Ramirez

Reviewed by PREreview

Metagenomes and Metagenome-Assembled Genomes from Tidal Lagoons at a New York City Waterfront Park

1. Sally Kong
2. Eliana Abrams
3. Yehuda Binik
4. Christina Cappelli
5. Mathew Chu
6. Taiyo Cornett
7. Isayah Culbertson
8. Epifania Garcia
9. Jada Henry
10. Kristy Lam
11. DB Lampman
12. Grace Morenko
13. Illusion Rivera
14. Tanasia Swift
15. Isabella Torres
16. Rayven Velez
17. Elliot Waxman
18. Serena Wessely
19. Anthony Yuen
20. Casey K. Lardner
21. JL Weissman

Reviewed by Arcadia Science

A Blueprint for Broadly Effective Bacteriophage Therapy Against Bacterial Infections

1. Minyoung Kevin Kim
2. Qingquan Chen
3. Arne Echterhof
4. Robert C. McBride
5. Nina Pennetzdorfer
6. Niaz Banaei
7. Elizabeth B. Burgener
8. Carlos E. Milla
9. Paul L. Bollyky

Reviewed by Rapid Reviews Infectious Diseases, Arcadia Science, PREreview

Modulation of host signalling pathways reveal a major role for Wnt signalling in the maturation of Plasmodium falciparum liver schizonts

1. Abhishek Kanyal
2. Geert-Jan van Gemert
3. Haoyu Wu
4. Alex van der Starre
5. Johannes HW de Wilt
6. Teun Bousema
7. Robert W. Sauerwein
8. Richard Bartfai
9. Annie SP Yang

Reviewed by Rapid Reviews Infectious Diseases

Mosquito immune cells enhance dengue and Zika virus dissemination in Aedes aegypti

1. David R. Hall
2. Rebecca M. Johnson
3. Hyeogsun Kwon
4. Zannatul Ferdous
5. S. Viridiana Laredo-Tiscareño
6. Bradley J. Blitvich
7. Doug E. Brackney
8. Ryan C. Smith

Reviewed by Rapid Reviews Infectious Diseases

Interleukin-27 is antiviral at the maternal-fetal interface

1. Madeline S. Merlino
2. Briah Barksdale
3. Seble G. Negatu
4. Rebecca L. Clements
5. Taylor Miller-Ensminger
6. Alexandra H. Lopez
7. Sneha Mani
8. Monica N. Mainigi
9. Christopher A. Hunter
10. Kellie A. Jurado

Reviewed by Arcadia Science

An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

1. Lai Wei
2. Shuiqing Liu
3. Shanshan Lu
4. Shengdong Luo
5. Xiaoping An
6. Huahao Fan
7. Weiwei Chen
8. Erguang Li
9. Yigang Tong
10. Lihua Song

Reviewed by Rapid Reviews Infectious Diseases

Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani

1. Supratim Pradhan
2. Dhruba Dhar
3. Debolina Manna
4. Shubhangi Chakraborty
5. Arkapriya Bhattacharyya
6. Khushi Chauhan
7. Rimi Mukherjee
8. Abhik Sen
9. Krishna Pandey
10. Soumen Das
11. Budhaditya Mukherjee

• Curated by eLife

  eLife Assessment

  This important study investigates the propensity of the intravacuolar pathogen, Leishmania, to scavenge lipids which it utilizes for its accelerated growth within macrophages. The authors present compelling evidence that supports this hypothesis, although the genetic basis for the parasite's requirement for lipids remains unresolved. The study adds to other work that has implicated pathogen-derived processes in the selective recruitment of vesicles to the pathogen-containing vacuole, based on the content of the cargo.

Reviewed by eLife