Microbiology

A recursive pathway for isoleucine biosynthesis arises from enzyme promiscuity

1. Vittorio Rainaldi
2. Stefano Donati
3. Sarah D’Adamo
4. Nico J Claassens

• Curated by eLife

  eLife Assessment

  The study reports a potential pathway for isoleucine biosynthesis mediated by the underground activity of AHASII, which converts glyoxylate and pyruvate to 2-ketobutyrate. While the findings are valuable in revealing a possible alternative route for isoleucine production, the evidence presented remains incomplete. More comprehensive biochemical experiments are required to substantiate the physiological feasibility of this pathway.

Reviewed by eLife

Polyamine depletion inhibits norovirus infection by blocking virus-induced apoptosis

1. Maryna Chaika
2. Heike Laschin
3. Marina Pekelis
4. Carmen Mirabelli
5. Sandra Niendorf
6. Christiane E. Wobus
7. Stefan Taube

Reviewed by preLights

Leaffooted bugs enrich local soil with their horizontally acquired symbiont

1. Bibek Singh Parajuli
2. John Teodosio
3. Alison Ravenscraft

Reviewed by Arcadia Science

Interferon-β induction heterogeneity during KSHV infection is correlated to levels and activation of the transcription factors ATF2 and RelA, and not IRF3

1. Machika Kaku
2. Marta Maria Gaglia

Reviewed by Review Commons

The glycoprotein quality control factor Malectin promotes coronavirus replication and viral protein biogenesis

1. Jonathan P Davies
2. Lars Plate

• Curated by eLife

  eLife Assessment

  This is an important study that utilizes proteomic and genetic approaches to identify the glycoprotein quality control factor malectin as a pro-viral host protein involved in the replication of coronavirus. The evidence supporting this conclusion is convincing, although continued elucidation of the mechanistic basis of malectin-mediated viral replication would further strengthen these findings. This work will be of interest to cell biologists studying the molecular mechanisms of glycoprotein quality control and virologists studying the host-pathogen interactions.

Reviewed by eLife