Microbiology

PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment

1. Binayak Sarkar
2. Jyotsna Singh
3. Mohit Yadav
4. Priya Sharma
5. Raman Deep Sharma
6. Shweta Singh
7. Aakash Chandramouli
8. Kritee Mehdiratta
9. Ashwani Kumar
10. Siddhesh S. Kamat
11. Devram S. Ghorpade
12. Debasisa Mohanty
13. Dhiraj Kumar
14. Rajesh S. Gokhale

Reviewed by preLights

MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions

1. Yongjin Liu
2. Sandra LaBonte
3. Courtney Brake
4. Carol LaFayette
5. Adam P. Rosebrock
6. Amy A. Caudy
7. Paul D. Straight

• Curated by eLife

  eLife assessment

  This paper reports on the transcriptional changes upon chloramphenicol-induced surface mobility of Bacillus subtilis, a phenomenon that can occur during co-incubation with Streptomyces venezuelae, a chloramphenicol producer. The work presented includes valuable and thorough transcriptomics data, which convincingly indicate that sub-lethal chloramphenicol triggers substantial changes in B. subtilis gene expression. There are, however, significant limitations and concerns whether the documented changes are causal for the phenotypes observed or simply correlated with these phenotypes; additionally, the notion that chloramphenicol triggers a 'division of labor' was incomplete and should be backed up experimentally.

Reviewed by eLife

A packaging signal-binding protein regulates the assembly checkpoint of integrative filamentous phages

1. Ting-Yu Yeh
2. Michael C. Feehley
3. Patrick J. Feehley
4. Vivian Y. Ooi
5. Yi-Yung Hung
6. Shao-Cheng Wang
7. Gregory P. Contreras

• Curated by eLife

  eLife assessment

  This valuable work describes a new protein factor that is required for filamentous phage assembly. Convincing evidence is provided for the binding of PSB15 to the packaging signal of the single-stranded DNA, Trx, and cardiolipin, and a mechanism for how the phage DNA is targeted to the assembly site in the bacterial inner membrane is presented. The work will be of interest to microbiologists.

Reviewed by eLife

Aspergillus dsRNA virus drives fungal fitness and pathogenicity in the mammalian host

1. Neta Shlezinger
2. Vanda Lerer
3. Marina Rocha
4. John Adeoye
5. Hilla Hayby

Reviewed by preLights

Detailing organelle division and segregation in Plasmodium falciparum

1. Julie M.J. Verhoef
2. Cas Boshoven
3. Felix Evers
4. Laura J. Akkerman
5. Barend C.A. Gijsbrechts
6. Marga van de Vegte-Bolmer
7. Geert-Jan van Gemert
8. Akhil B. Vaidya
9. Taco W.A. Kooij

Reviewed by Review Commons

Importin-7-dependent nuclear localization of the Flavivirus core protein is required for infectious virus production

1. Yumi Itoh
2. Makoto Tokunaga
3. Yoichi Miyamoto
4. Tatsuya Suzuki
5. Akira Takada
6. Akinori Ninomiya
7. Mami Matsuda
8. Yoshihiro Yoneda
9. Masahiro Oka
10. Ryosuke Suzuki
11. Yoshiharu Matsuura
12. Toru Okamoto

Reviewed by Review Commons

Conserved jumbo phage factors required for protein import into a phage nucleus

1. Claire Kokontis
2. Timothy A Klein
3. Sukrit Silas
4. Joseph Bondy-Denomy

Reviewed by Arcadia Science

Prophages express a type IV pilus component to provide anti-phage defence

1. Kristina M. Sztanko
2. P. Nathael Javorčík
3. Alexa D. Fitzpatrick
4. Tatiana Lenskaia
5. Karen L. Maxwell
6. Alan R. Davidson

Reviewed by Arcadia Science

Design of a new model yeast consortium for ecological studies of enological fermentation

1. Eléonore Pourcelot
2. Audrey Vigna
3. Thérèse Marlin
4. Virginie Galeote
5. Thibault Nidelet

Reviewed by Arcadia Science

Neutralizing gut-derived lipopolysaccharide as a novel therapeutic strategy for severe leptospirosis

1. Xufeng Xie
2. Xi Chen
3. Shilei Zhang
4. Jiuxi Liu
5. Wenlong Zhang
6. Yongguo Cao

• Curated by eLife

  eLife assessment

  The gut microbiota influences many infectious diseases; however, its role Leptospirosis remains unclear. In this fundamental work, Xie et al. use a hamster model to show that Leptospira infection leads to gut pathology, an altered gut microbiota, and increased translocation. A combined use of antibiotics and LPS neutralization prolonged survival, providing a potential new therapeutic approach. This study utilizes compelling methods to provide new insights into this emerging disease, which could be dissected further in future studies aimed at gaining mechanistic insight and assessing the translational relevance of these discoveries.

Reviewed by eLife