Immunology

An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

1. Lindsay Broadbent
2. Connor G. G. Bamford
3. Guillermo Lopez Campos
4. Sheerien Manzoor
5. David Courtney
6. Ahlam Ali
7. Olivier Touzelet
8. Conall McCaughey
9. Ken Mills
10. Ultan F. Power

Reviewed by ScreenIT

Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice

1. Saravanan Subramaniam
2. Ryan Matthew Hekman
3. Archana Jayaraman
4. Aoife Kateri O’Connell
5. Paige Montanaro
6. Benjamin Blum
7. Devin Kenney
8. Maria Ericsson
9. Katya Ravid
10. Nicholas A Crossland
11. Andrew Emili
12. Florian Douam
13. Markus Bosmann

Reviewed by ScreenIT

Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

1. Alexander Stewart
2. Emma Sinclair
3. Joseph Chi-Fung Ng
4. Joselli Silva O’Hare
5. Audrey Page
6. Ilaria Serangeli
7. Christian Margreitter
8. Federica Orsenigo
9. Katherine Longman
10. Cecile Frampas
11. Catia Costa
12. Holly-May Lewis
13. Nora Kasar
14. Bryan Wu
15. David Kipling
16. Peter JM Openshaw
17. Christopher Chiu
18. J Kenneth Baillie
19. Janet T. Scott
20. Malcolm G. Semple
21. Melanie J. Bailey
22. Franca Fraternali
23. Deborah K. Dunn-Walters

Reviewed by ScreenIT

T Cell Predominant Response to AAV-Spike Protects hACE2 Mice from SARS-CoV-2 Pneumonia

1. Christopher D. Greer
2. Coral M. Kasden
3. Leon Morales
4. Kendall A. Lundgreen
5. Philip D. Hicks
6. Lilia J. Carpenter
7. Cristhian Salas-Quinchucua
8. Elisia D. Tichy
9. Albert M. Maguire
10. Jennifer G. Hoffman
11. Robin J. Bailey
12. Shangzhen Zhou
13. Angela Luo
14. Steven J. Chomistek
15. Benjamin W. Kozyak
16. Charles R. Bridges
17. Gilad S. Gordon
18. Geoffrey C. Tabin
19. Paul F. Bates
20. Jorge E. Osorio
21. Jean Bennett
22. Hansell H. Stedman

Reviewed by ScreenIT

Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR

1. Christopher Szeto
2. Andrea T. Nguyen
3. Christian A. Lobos
4. Demetra S. M. Chatzileontiadou
5. Dhilshan Jayasinghe
6. Emma J. Grant
7. Alan Riboldi-Tunnicliffe
8. Corey Smith
9. Stephanie Gras

Reviewed by ScreenIT

Durability of SARS-CoV-2-specific T cell responses at 12-months post-infection

1. Zhongyan Lu
2. Eric D. Laing
3. Jarina Pena-Damata
4. Katherine Pohida
5. Marana S. Tso
6. Emily C. Samuels
7. Nusrat J. Epsi
8. Batsukh Dorjbal
9. Camille Lake
10. Stephanie A. Richard
11. Ryan C. Maves
12. David A. Lindholm
13. Julia Rozman
14. Caroline English
15. Nikhil Huprikar
16. Katrin Mende
17. Rhonda E. Colombo
18. Christopher J. Colombo
19. Christopher C. Broder
20. Anuradha Ganesan
21. Charlotte A. Lanteri
22. Brian K. Agan
23. David Tribble
24. Mark P. Simons
25. Clifton L. Dalgard
26. Paul W. Blair
27. Josh Chenoweth
28. Simon D. Pollett
29. Andrew L. Snow
30. Timothy H. Burgess
31. Allison M.W. Malloy
32. the EPICC COVID-19 Cohort Study Group

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ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

1. Riem Gawish
2. Philipp Starkl
3. Lisabeth Pimenov
4. Anastasiya Hladik
5. Karin Lakovits
6. Felicitas Oberndorfer
7. Shane JF Cronin
8. Anna Ohradanova-Repic
9. Gerald Wirnsberger
10. Benedikt Agerer
11. Lukas Endler
12. Tümay Capraz
13. Jan W Perthold
14. Domagoj Cikes
15. Rubina Koglgruber
16. Astrid Hagelkruys
17. Nuria Montserrat
18. Ali Mirazimi
19. Louis Boon
20. Hannes Stockinger
21. Andreas Bergthaler
22. Chris Oostenbrink
23. Josef M Penninger
24. Sylvia Knapp

• Curated by eLife

  Evaluation Summary:

  To establish a mouse model for the SARS-CoV-2 infection, Gawish and colleagues performed serial passage of a human virus isolate in mice. They show that the mouse-adapted SARS-CoV-2 variant remains dependent on ACE2 for efficient infection and recapitulates some clinical characteristics of COVID-19. In addition, they demonstrate that inhalation of recombinant ACE2 protected mice from mouse COVID-19 suggesting this this model will be useful for the testing of antiviral agents.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife, ScreenIT

Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

1. Kizzmekia S. Corbett
2. Matthew Gagne
3. Danielle A. Wagner
4. Sarah O’ Connell
5. Sandeep R. Narpala
6. Dillon R. Flebbe
7. Shayne F. Andrew
8. Rachel L. Davis
9. Barbara Flynn
10. Timothy S. Johnston
11. Christopher Stringham
12. Lilin Lai
13. Daniel Valentin
14. Alex Van Ry
15. Zackery Flinchbaugh
16. Anne P. Werner
17. Juan I. Moliva
18. Manjari Sriparna
19. Sijy O’Dell
20. Stephen D. Schmidt
21. Courtney Tucker
22. Angela Choi
23. Matthew Koch
24. Kevin W. Bock
25. Mahnaz Minai
26. Bianca M. Nagata
27. Gabriela S. Alvarado
28. Amy R. Henry
29. Farida Laboune
30. Chaim A. Schramm
31. Yi Zhang
32. Lingshu Wang
33. Misook Choe
34. Seyhan Boyoglu-Barnum
35. Wei Shi
36. Evan Lamb
37. Saule T. Nurmukhambetova
38. Samantha J. Provost
39. Mitzi M. Donaldson
40. Josue Marquez
41. John-Paul M. Todd
42. Anthony Cook
43. Alan Dodson
44. Andrew Pekosz
45. Eli Boritz
46. Aurélie Ploquin
47. Nicole Doria-Rose
48. Laurent Pessaint
49. Hanne Andersen
50. Kathryn E. Foulds
51. John Misasi
52. Kai Wu
53. Andrea Carfi
54. Martha C. Nason
55. John Mascola
56. Ian N. Moore
57. Darin K. Edwards
58. Mark G. Lewis
59. Mehul S. Suthar
60. Mario Roederer
61. Adrian McDermott
62. Daniel C. Douek
63. Nancy J. Sullivan
64. Barney S. Graham
65. Robert A. Seder

Reviewed by ScreenIT

Covid-19 vaccine immunogenicity in people living with HIV-1

1. Lauriane Nault
2. Lorie Marchitto
3. Guillaume Goyette
4. Daniel Tremblay-Sher
5. Claude Fortin
6. Valérie Martel-Laferrière
7. Benoît Trottier
8. Jonathan Richard
9. Madeleine Durand
10. Daniel Kaufmann
11. Andrés Finzi
12. Cécile Tremblay

Reviewed by ScreenIT

Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

1. Sheng Jiang
2. Shuting Wu
3. Gan Zhao
4. Yue He
5. Linlin Bao
6. Jiangning Liu
7. Chuan Qin
8. Jiawang Hou
9. Yuan Ding
10. Alex Cheng
11. Brian Jiang
12. John Wu
13. Jian Yan
14. Laurent Humeau
15. Ami Patella
16. David B. Weiner
17. Kate Broderick
18. Bin Wang

Reviewed by ScreenIT