Immunology

A trimeric NTD and RBD SARS-CoV-2 subunit vaccine induced protective immunity in CAG-hACE2 transgenic mice and rhesus macaques

1. Jiaping Yu
2. Wenrong Yao
3. Yingsong Hu
4. Shuang Wu
5. Jiao Li
6. Hongjun Zhou
7. Kunxue Hong
8. Jianping Chen
9. Longding Liu
10. Ke Lan
11. Feng-Cai Zhu
12. Yong Liu

Reviewed by ScreenIT

Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in nonhuman primates is coincident with an anamnestic antibody response in the lower airway

1. Matthew Gagne
2. Kizzmekia S. Corbett
3. Barbara J. Flynn
4. Kathryn E. Foulds
5. Danielle A. Wagner
6. Shayne F. Andrew
7. John-Paul M. Todd
8. Christopher Cole Honeycutt
9. Lauren McCormick
10. Saule T. Nurmukhambetova
11. Meredith E. Davis-Gardner
12. Laurent Pessaint
13. Kevin W. Bock
14. Bianca M. Nagata
15. Mahnaz Minai
16. Anne P. Werner
17. Juan I. Moliva
18. Courtney Tucker
19. Cynthia G. Lorang
20. Bingchun Zhao
21. Elizabeth McCarthy
22. Anthony Cook
23. Alan Dodson
24. Prakriti Mudvari
25. Jesmine Roberts-Torres
26. Farida Laboune
27. Lingshu Wang
28. Adrienne Goode
29. Swagata Kar
30. Seyhan Boyoglu-Barnum
31. Eun Sung Yang
32. Wei Shi
33. Aurélie Ploquin
34. Nicole Doria-Rose
35. Andrea Carfi
36. John R. Mascola
37. Eli A. Boritz
38. Darin K. Edwards
39. Hanne Andersen
40. Mark G. Lewis
41. Mehul S. Suthar
42. Barney S. Graham
43. Mario Roederer
44. Ian N. Moore
45. Martha C. Nason
46. Nancy J. Sullivan
47. Daniel C. Douek
48. Robert A. Seder

Reviewed by ScreenIT

Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

1. Wooseob Kim
2. Julian Q. Zhou
3. Alexandria J. Sturtz
4. Stephen C. Horvath
5. Aaron J. Schmitz
6. Tingting Lei
7. Elizaveta Kalaidina
8. Mahima Thapa
9. Wafaa B. Alsoussi
10. Alem Haile
11. Michael K. Klebert
12. Teresa Suessen
13. Luis Parra-Rodriguez
14. Philip A. Mudd
15. William D. Middleton
16. Sharlene A. Teefey
17. Iskra Pusic
18. Jane A. O’Halloran
19. Rachel M. Presti
20. Jackson S. Turner
21. Ali H. Ellebedy

Reviewed by ScreenIT

Single cell RNA-seq uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

1. Marina Aznaourova
2. Nils Schmerer
3. Harshavardhan Janga
4. Zhenhua Zhang
5. Kim Pauck
6. Judith Hoppe
7. Sarah M Volkers
8. Daniel Wendisch
9. Philipp Georg
10. Margrit Gündisch
11. Elisabeth Mack
12. Chrysanthi Skevaki
13. Christian Keller
14. Christian Bauer
15. Wilhelm Bertrams
16. Andrea Nist
17. Thorsten Stiewe
18. Achim D Gruber
19. Clemens Ruppert
20. Yang Li
21. Holger Garn
22. Leif E Sander
23. Bernd Schmeck
24. Leon N Schulte

Reviewed by ScreenIT

SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19

1. Giovanny J. Martínez-Colón
2. Kalani Ratnasiri
3. Heping Chen
4. Sizun Jiang
5. Elizabeth Zanley
6. Arjun Rustagi
7. Renu Verma
8. Han Chen
9. Jason R. Andrews
10. Kirsten D. Mertz
11. Alexandar Tzankov
12. Dan Azagury
13. Jack Boyd
14. Garry P. Nolan
15. Christian M. Schürch
16. Matthias S. Matter
17. Catherine A. Blish
18. Tracey L. McLaughlin

Reviewed by ScreenIT

Potent antibody immunity to SARS‐CoV‐2 variants elicited by a third dose of inactivated vaccine

1. Bin Ju
2. Bing Zhou
3. Shuo Song
4. Qing Fan
5. Xiangyang Ge
6. Haiyan Wang
7. Lin Cheng
8. Huimin Guo
9. Dan Shu
10. Lei Liu
11. Zheng Zhang

Reviewed by ScreenIT

Marked enhancement of neutralizing antibody and IFN-γ T-cell responses by GX-19N DNA booster in mice primed with inactivated vaccine

1. Yong Bok Seo
2. Duckhyang Shin
3. You Suk Suh
4. Juyoung Na
5. Ji In Ryu
6. Young Chul Sung

Reviewed by ScreenIT

Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2

1. Oscar Rosas Mejia
2. Erin S. Gloag
3. Jianying Li
4. Marisa Ruane-Foster
5. Tiffany A. Claeys
6. Daniela Farkas
7. Laszlo Farkas
8. Gang Xin
9. Richard T. Robinson

Reviewed by ScreenIT

SARS‐CoV ‐2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytes

1. Lilian Gomes de Oliveira
2. Yan de Souza Angelo
3. Pedro Yamamoto
4. Victor Corasolla Carregari
5. Fernanda Crunfli
6. Guilherme Reis‐de‐Oliveira
7. Lícia Costa
8. Pedro Henrique Vendramini
9. Érica Almeida Duque
10. Nilton Barreto dos Santos
11. Egidi Mayara Firmino
12. Isadora Marques Paiva
13. Glaucia Maria Almeida
14. Adriano Sebollela
15. Carolina Manganeli Polonio
16. Nagela Ghabdan Zanluqui
17. Marília Garcia de Oliveira
18. Patrick da Silva
19. Gustavo Gastão Davanzo
20. Marina Caçador Ayupe
21. Caio Loureiro Salgado
22. Antônio Francisco de Souza Filho
23. Marcelo Valdemir de Araújo
24. Taiana Tainá Silva‐Pereira
25. Angélica Cristine de Almeida Campos
26. Luiz Gustavo Bentim Góes
27. Marielton dos Passos Cunha
28. Elia Garcia Caldini
29. Maria Regina D'Império Lima
30. Denise Morais Fonseca
31. Ana Márcia de Sá Guimarães
32. Paola Camargo Minoprio
33. Carolina Demarchi Munhoz
34. Cláudia Madalena Cabrera Mori
35. Pedro Manoel Moraes‐Vieira
36. Thiago Mattar Cunha
37. Daniel Martins‐de‐Souza
38. Jean Pierre Schatzmann Peron

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving

1. Kenneth B Hoehn
2. Jackson S Turner
3. Frederick I Miller
4. Ruoyi Jiang
5. Oliver G Pybus
6. Ali H Ellebedy
7. Steven H Kleinstein

• Curated by eLife

  Evaluation Summary:

  The manuscript by Hoehn et al use a novel approach to quantify the somatic evolution in B cells. It brings together existing datasets to investigate the evidence for detectable evolution across longitudinal samples of BCR repertoires. This work provides significant new insight into which stimuli induce effective immune responses, and has the potential to improve vaccine design. Notably, these results are of interest for characterizing B cell responses, especially to vaccinations that induce a poor immune response, such as influenza.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife