Immunology

Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving

1. Kenneth B Hoehn
2. Jackson S Turner
3. Frederick I Miller
4. Ruoyi Jiang
5. Oliver G Pybus
6. Ali H Ellebedy
7. Steven H Kleinstein

• Curated by eLife

  Evaluation Summary:

  The manuscript by Hoehn et al use a novel approach to quantify the somatic evolution in B cells. It brings together existing datasets to investigate the evidence for detectable evolution across longitudinal samples of BCR repertoires. This work provides significant new insight into which stimuli induce effective immune responses, and has the potential to improve vaccine design. Notably, these results are of interest for characterizing B cell responses, especially to vaccinations that induce a poor immune response, such as influenza.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps

1. Brendan Antiochos
2. Daniela Trejo-Zambrano
3. Paride Fenaroli
4. Avi Rosenberg
5. Alan Baer
6. Archit Garg
7. Jungsan Sohn
8. Jessica Li
9. Michelle Petri
10. Daniel W Goldman
11. Christopher Mecoli
12. Livia Casciola-Rosen
13. Antony Rosen

• Curated by eLife

  Evaluation Summary:

  This manuscript identifies the DNA sensor AIM2 as a target of auto-antibodies in the human autoimmune disease systemic lupus erythematosus. Importantly, the authors provide evidence that AIM2 protects extracellular DNA from destruction and propose that this property may enhance the autoimmune response to the DNA and associated proteins. The work may therefore provide an important underlying mechanism for a prevalent and important human autoimmune disease.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination

1. Runhong Zhou
2. Pui Wang
3. Yik-Chun Wong
4. Haoran Xu
5. Siu-Ying Lau
6. Li Liu
7. Bobo Wing-Yee Mok
8. Qiaoli Peng
9. Na Liu
10. Kin-Fai Woo
11. Shaofeng Deng
12. Rachel Chun-Yee Tam
13. Haode Huang
14. Anna Jinxia Zhang
15. Dongyan Zhou
16. Biao Zhou
17. Chun-Yin Chan
18. Zhenglong Du
19. Dawei Yang
20. Ka-Kit Au
21. Kwok-Yung Yuen
22. Honglin Chen
23. Zhiwei Chen

Reviewed by ScreenIT

An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant replication in rhesus macaques

1. Yongjun Sui
2. Jianping Li
3. Hanne Andersen
4. Roushu Zhang
5. Sunaina K Prabhu
6. Tanya Hoang
7. David Venzon
8. Anthony Cook
9. Renita Brown
10. Elyse Teow
11. Jason Velasco
12. Laurent Pessaint
13. Ian N Moore
14. Laurel Lagenaur
15. Jim Talton
16. Matthew W Breed
17. Josh Kramer
18. Kevin W Bock
19. Mahnaz Minai
20. Bianca M Nagata
21. Hyoyoung Choo-Wosoba
22. Mark G Lewis
23. Lai-Xi Wang
24. Jay A Berzofsky

Reviewed by ScreenIT

Preparation of ingestible antibodies to neutralize the binding of SarsCoV2 RBD (receptor binding domain) to human ACE2 Receptor

1. Gopi Kadiyala
2. Subramanian Iyer
3. Kranti Meher
4. Subhramanyam Vangala
5. Satish Chandran
6. Uday Saxena

Reviewed by ScreenIT

High-titer neutralization of Mu and C.1.2 SARS-CoV-2 variants by vaccine-elicited antibodies of previously infected individuals

1. Takuya Tada
2. Hao Zhou
3. Belinda M. Dcosta
4. Marie I. Samanovic
5. Amber Cornelius
6. Ramin S. Herati
7. Mark J. Mulligan
8. Nathaniel R. Landau

Reviewed by ScreenIT

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

1. Young-Jun Park
2. Anna De Marco
3. Tyler N. Starr
4. Zhuoming Liu
5. Dora Pinto
6. Alexandra C. Walls
7. Fabrizia Zatta
8. Samantha K. Zepeda
9. John E. Bowen
10. Kaitlin R. Sprouse
11. Anshu Joshi
12. Martina Giurdanella
13. Barbara Guarino
14. Julia Noack
15. Rana Abdelnabi
16. Shi-Yan Caroline Foo
17. Laura E. Rosen
18. Florian A. Lempp
19. Fabio Benigni
20. Gyorgy Snell
21. Johan Neyts
22. Sean P. J. Whelan
23. Herbert W. Virgin
24. Jesse D. Bloom
25. Davide Corti
26. Matteo Samuele Pizzuto
27. David Veesler

Reviewed by ScreenIT

Mapping Molecular Gene Signatures Among Respiratory Viruses Based on Large-Scale and Genome-wide Transcriptomics Analysis

1. Thomas Smith
2. Mohammed A. Rohaim
3. Muhammad Munir

Reviewed by ScreenIT

Preclinical Efficacy of IMM-BCP-01, a Highly Active Patient-Derived Anti-SARS-CoV-2 Antibody Cocktail

1. Pavel A. Nikitin
2. Jillian M. DiMuzio
3. John P. Dowling
4. Nirja B. Patel
5. Jamie L. Bingaman-Steele
6. Baron C. Heimbach
7. Noeleya Henriquez
8. Chris Nicolescu
9. Antonio Polley
10. Eden L. Sikorski
11. Raymond J. Howanski
12. Mitchell Nath
13. Halley Shukla
14. Suzanne M. Scheaffer
15. James P. Finn
16. Li-Fang Liang
17. Todd Smith
18. Nadia Storm
19. Lindsay G. A. McKay
20. Rebecca I. Johnson
21. Lauren E. Malsick
22. Anna N. Honko
23. Anthony Griffiths
24. Michael S. Diamond
25. Purnanand Sarma
26. Dennis H. Geising
27. Michael J. Morin
28. Matthew K. Robinson

Reviewed by ScreenIT

Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination

1. George Elias
2. Pieter Meysman
3. Esther Bartholomeus
4. Nicolas De Neuter
5. Nina Keersmaekers
6. Arvid Suls
7. Hilde Jansens
8. Aisha Souquette
9. Hans De Reu
10. Marie-Paule Emonds
11. Evelien Smits
12. Eva Lion
13. Paul G Thomas
14. Geert Mortier
15. Pierre Van Damme
16. Philippe Beutels
17. Kris Laukens
18. Viggo Van Tendeloo
19. Benson Ogunjimi

• Curated by eLife

  Evaluation Summary:

  By using modern high-throughput sequencing this paper demonstrates the antibody mediated immune responses that are elicited by vaccination are improved by pre-existing memory CD4 T cell responses. Moreover, the experimental data are an important contribution and may also be useful as a data resource for future research. All reviewers agree that the findings are of great interest. However, there are still some clarifications needed in statistical analytical and validations so they convincingly support the conclusions.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife