Immunology

Longitudinal characterisation of phagocytic and neutralisation functions of anti-Spike antibodies in plasma of patients after SARS-CoV-2 infection

1. Anurag Adhikari
2. Arunasingam Abayasingam
3. Chaturaka Rodrigo
4. David Agapiou
5. Elvis Pandzic
6. Nicholas A Brasher
7. Bentotage Samitha Madushan Fernando
8. Elizabeth Keoshkerian
9. Hui Li
10. Ha Na Kim
11. Megan Lord
12. Gordona Popovic
13. William Rawlinson
14. Michael Mina
15. Jeffrey J Post
16. Bernard Hudson
17. Nicole Gilroy
18. Adam W. Bartlett
19. Golo Ahlenstiel
20. Branka Grubor-Bauk
21. Dominic Dwyer
22. Pamela Konecny
23. Andrew R Lloyd
24. Marianne Martinello
25. Rowena A Bull
26. Nicodemus Tedla

Reviewed by ScreenIT

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant

1. Venkata-Viswanadh Edara
2. Kelly E. Manning
3. Madison Ellis
4. Lilin Lai
5. Kathryn M. Moore
6. Stephanie L. Foster
7. Katharine Floyd
8. Meredith E. Davis-Gardner
9. Grace Mantus
10. Lindsay E. Nyhoff
11. Sarah Bechnak
12. Ghina Alaaeddine
13. Amal Naji
14. Hady Samaha
15. Matthew Lee
16. Laurel Bristow
17. Matthew Gagne
18. Jesmine Roberts-Torres
19. Amy R. Henry
20. Sucheta Godbole
21. Arash Grakoui
22. Marybeth Saxton
23. Anne Piantadosi
24. Jesse J. Waggoner
25. Daniel C. Douek
26. Nadine Rouphael
27. Jens Wrammert
28. Mehul S. Suthar

Reviewed by ScreenIT

Blockade of TMPRSS2-mediated priming of SARS-CoV-2 by lactoferricin

1. Anna Ohradanova-Repic
2. Rostislav Skrabana
3. Laura Gebetsberger
4. Gabor Tajti
5. Peter Baráth
6. Gabriela Ondrovičová
7. Romana Praženicová
8. Nikola Jantova
9. Patricia Hrasnova
10. Hannes Stockinger
11. Vladimir Leksa

Reviewed by ScreenIT

Immune escape of SARS-CoV-2 Omicron variant from mRNA vaccination-elicited RBD-specific memory B cells

1. Aurélien Sokal
2. Matteo Broketa
3. Annalisa Meola
4. Giovanna Barba-Spaeth
5. Ignacio Fernández
6. Slim Fourati
7. Imane Azzaoui
8. Andrea de La Selle
9. Alexis Vandenberghe
10. Anais Roeser
11. Magali Bouvier-Alias
12. Etienne Crickx
13. Laetitia Languille
14. Marc Michel
15. Bertrand Godeau
16. Sébastien Gallien
17. Giovanna Melica
18. Yann Nguyen
19. Virginie Zarrouk
20. Florence Canoui-Poitrine
21. France Noizat-Pirenne
22. Jérôme Megret
23. Jean-Michel Pawlotsky
24. Simon Fillatreau
25. Etienne Simon-Lorière
26. Jean-Claude Weill
27. Claude-Agnès Reynaud
28. Félix A. Rey
29. Pierre Bruhns
30. Pascal Chappert
31. Matthieu Mahévas

Reviewed by ScreenIT

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

1. Noella Lopes
2. Nicolas Boucherit
3. Jérémy C Santamaria
4. Nathan Provin
5. Jonathan Charaix
6. Pierre Ferrier
7. Matthieu Giraud
8. Magali Irla

• Curated by eLife

  Evaluation Summary:

  This manuscript will be of interest to readers in the field of immunology and especially in the induction of immune tolerance in the thymus. The work uses several mouse models to substantially broaden the current understanding of MHCII/TCR -mediated cell-cell crosstalk in the thymus and suggests a novel mechanism that contributes to the generation of functional and self-tolerant T-cells.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

1. Magdalena L Russell
2. Aisha Souquette
3. David M Levine
4. Stefan A Schattgen
5. E Kaitlynn Allen
6. Guillermina Kuan
7. Noah Simon
8. Angel Balmaseda
9. Aubree Gordon
10. Paul G Thomas
11. Frederick A Matsen
12. Philip Bradley

• Curated by eLife

  Evaluation Summary:

  This study demonstrates that differences in areas outside the regions that encode the TCR genes can affect the properties of TCRs that get made. This paper will be of interest to a broad swathe of immunologists who study such variable lymphocyte receptors. It combines several large datasets in an extremely statistically rigorous analysis, producing results consistent with but substantially expanding upon the prior knowledge of the field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

SARS-CoV-2 spike conformation determines plasma neutralizing activity

1. John E. Bowen
2. Alexandra C. Walls
3. Anshu Joshi
4. Kaitlin R. Sprouse
5. Cameron Stewart
6. M. Alejandra Tortorici
7. Nicholas M. Franko
8. Jennifer K. Logue
9. Ignacio G. Mazzitelli
10. Sasha W Tiles
11. Kumail Ahmed
12. Asefa Shariq
13. Gyorgy Snell
14. Najeeha Talat Iqbal
15. Jorge Geffner
16. Alessandra Bandera
17. Andrea Gori
18. Renata Grifantini
19. Helen Y. Chu
20. Wesley C. Van Voorhis
21. Davide Corti
22. David Veesler

Reviewed by ScreenIT

Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice

1. Ana C. Puhl
2. Giovanni F. Gomes
3. Samara Damasceno
4. Ethan J. Fritch
5. James A. Levi
6. Nicole J. Johnson
7. Frank Scholle
8. Lakshmanane Premkumar
9. Brett L. Hurst
10. Felipe LeeMontiel
11. Flavio P. Veras
12. Sabrina S. Batah
13. Alexandre T. Fabro
14. Nathaniel J. Moorman
15. Boyd L. Yount
16. Rebekah Dickmander
17. Ralph Baric
18. Kenneth H. Pearce
19. Fernando Q. Cunha
20. José C. Alves-Filho
21. Thiago M. Cunha
22. Sean Ekins

Reviewed by ScreenIT

Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen

1. Manon Nayrac
2. Mathieu Dubé
3. Gérémy Sannier
4. Alexandre Nicolas
5. Lorie Marchitto
6. Olivier Tastet
7. Alexandra Tauzin
8. Nathalie Brassard
9. Raphaël Lima-Barbosa
10. Guillaume Beaudoin-Bussières
11. Dani Vézina
12. Shang Yu Gong
13. Mehdi Benlarbi
14. Romain Gasser
15. Annemarie Laumaea
16. Jérémie Prévost
17. Catherine Bourassa
18. Gabrielle Gendron-Lepage
19. Halima Medjahed
20. Guillaume Goyette
21. Gloria-Gabrielle Ortega-Delgado
22. Mélanie Laporte
23. Julia Niessl
24. Laurie Gokool
25. Chantal Morrisseau
26. Pascale Arlotto
27. Jonathan Richard
28. Justin Bélair
29. Alexandre Prat
30. Cécile Tremblay
31. Valérie Martel-Laferrière
32. Andrés Finzi
33. Daniel E. Kaufmann

Reviewed by ScreenIT

Reduced sera neutralization to Omicron SARS-CoV-2 by both inactivated and protein subunit vaccines and the convalescents

1. Xin Zhao
2. Dedong Li
3. Wenjing Ruan
4. Rong Zhang
5. Anqi Zheng
6. Shitong Qiao
7. Xinlei Zheng
8. Yingze Zhao
9. Zhihai Chen
10. Lianpan Dai
11. Pengcheng Han
12. George F. Gao

Reviewed by ScreenIT