Immunology

High temporal resolution systems profiling reveals distinct patterns of interferon response after Covid-19 mRNA vaccination and SARS-CoV2 infection

1. Darawan Rinchai
2. Sara Deola
3. Gabriele Zoppoli
4. Basirudeen Syed Ahamed Kabeer
5. Sara Taleb
6. Igor Pavlovski
7. Selma Maacha
8. Giusy Gentilcore
9. Mohammed Toufiq
10. Lisa Mathew
11. Li Liu
12. Fazulur Rehaman Vempalli
13. Ghada Mubarak
14. Stephan Lorenz
15. Irene Sivieri
16. Gabriella Cirmena
17. Chiara Dentone
18. Paola Cuccarolo
19. Daniele Roberto Giacobbe
20. Federico Baldi
21. Alberto Garbarino
22. Benedetta Cigolini
23. Paolo Cremonesi
24. Michele Bedognetti
25. Alberto Ballestrero
26. Matteo Bassetti
27. Boris P. Hejblum
28. Tracy Augustine
29. Nicholas Van Panhuys
30. Rodolphe Thiebaut
31. Ricardo Branco
32. Tracey Chew
33. Maryam Shojaei
34. Kirsty Short
35. Carl Feng
36. PREDICT-19 consortium
37. Susu M. Zughaier
38. Andrea De Maria
39. Benjamin Tang
40. Ali Ait Hssain
41. Davide Bedognetti
42. Jean-Charles Grivel
43. Damien Chaussabel

Reviewed by ScreenIT

CHARM: COVID-19 Health Action Response for Marines–Association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 test

1. Martha Sedegah
2. Chad Porter
3. Michael R. Hollingdale
4. Harini Ganeshan
5. Jun Huang
6. Carl W. Goforth
7. Maria Belmonte
8. Arnel Belmonte
9. Dawn L. Weir
10. Rhonda A. Lizewski
11. Stephen E. Lizewski
12. Stuart C. Sealfon
13. Vihasi Jani
14. Ying Cheng
15. Sandra Inoue
16. Rachael Velasco
17. Eileen Villasante
18. Peifang Sun
19. Andrew G. Letizia

Reviewed by ScreenIT

SARS-CoV-2 T cell responses are expected to remain robust against Omicron

1. Syed Faraz Ahmed
2. Ahmed Abdul Quadeer
3. Matthew R. McKay

Reviewed by ScreenIT

Th2 single-cell heterogeneity and clonal distribution at distant sites in helminth-infected mice

1. Daniel Radtke
2. Natalie Thuma
3. Christine Schülein
4. Philipp Kirchner
5. Arif B Ekici
6. Kilian Schober
7. David Voehringer

• Curated by eLife

  Evaluation Summary:

  A well written and informative study that uses scRNA-seq to examine Th2 biology in worm infections. It offers a unique angle for better defining Th2 heterogeneity and differentiation in vivo.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

1. Sabela Rodríguez-Lorenzo
2. Lynn van Olst
3. Carla Rodriguez-Mogeda
4. Alwin Kamermans
5. Susanne MA van der Pol
6. Ernesto Rodríguez
7. Gijs Kooij
8. Helga E de Vries

• Curated by eLife

  Evaluation Summary:

  This is a well-written, well-illustrated and well-conducted study of the immune cell landscape of multiple sclerosis (MS) tissue, with a particular focus on the periventricular region (septum) and choroid plexus, using single cell mass cytometry (CyTOF). Overall the work is an impressive analysis of an understudied cell-type in MS, and represents an important resource. It will be important to follow up to establish how representative the findings are given the heterogeneity of the disease and the limited population studied here.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

1. Takahisa Miyao
2. Maki Miyauchi
3. S Thomas Kelly
4. Tommy W Terooatea
5. Tatsuya Ishikawa
6. Eugene Oh
7. Sotaro Hirai
8. Kenta Horie
9. Yuki Takakura
10. Houko Ohki
11. Mio Hayama
12. Yuya Maruyama
13. Takao Seki
14. Hiroto Ishii
15. Haruka Yabukami
16. Masaki Yoshida
17. Azusa Inoue
18. Asako Sakaue-Sawano
19. Atsushi Miyawaki
20. Masafumi Muratani
21. Aki Minoda
22. Nobuko Akiyama
23. Taishin Akiyama

• Curated by eLife

  Evaluation Summary:

  The present work by Miyao and Miyauchi et al. provides new insights into the heterogeneity of mTEC. With single-cell approaches and the Fucci2a mouse model, they have found a proliferating mTEC sub-population that may be a precursor of mature mTECs expressing the Aire gene. The findings are potentially important for the field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

The T cell receptor repertoire reflects the dynamics of the immune response to vaccination

1. Kevin Mohammed
2. Austin Meadows
3. Saboor Hekmaty
4. Sandra Hatem
5. Viviana Simon
6. Anitha D. Jayaprakash
7. Ravi Sachidanandam

Reviewed by ScreenIT

CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

1. Yang Li
2. Yan Wu
3. Elena A Federzoni
4. Xiaodan Wang
5. Andre Dharmawan
6. Xiaoyi Hu
7. Hui Wang
8. Robert J Hawley
9. Sean Stevens
10. Megan Sykes
11. Yong-Guang Yang

• Curated by eLife

  Evaluation Summary:

  The manuscript shows that CD47, which provides inhibitory signals to myeloid cells via SIRP1alpha, is released in exosomal form by cells expressing it, and these exosomes can stick stably to other cells, resulting in CD47-mediated protection of these cells from phagocytosis by myeloid cells. The data are striking, and would be of interest to researchers working in both mechanistic and tranlational aspects of transplant-related immunoregulation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

A novel bacterial protease inhibitor adjuvant in RBD-based COVID-19 vaccine formulations increases neutralizing antibodies, specific germinal center B cells and confers protection against SARS-CoV-2 infection

1. Lorena M. Coria
2. Lucas M. Saposnik
3. Celeste Pueblas Castro
4. Eliana F. Castro
5. Laura A. Bruno
6. William B. Stone
7. Paula S. Pérez
8. M. Laura Darriba
9. Lucia B. Chemes
10. Julieta Alcain
11. Ignacio Mazzitelli
12. Augusto Varese
13. Melina Salvatori
14. Albert J. Auguste
15. Diego E Álvarez
16. Karina A. Pasquevich
17. Juliana Cassataro

Reviewed by ScreenIT