Immunology

Host chitinase 3-like-1 is a universal therapeutic target for SARS-CoV-2 viral variants in COVID-19

1. Suchitra Kamle
2. Bing Ma
3. Chang Min Lee
4. Gail Schor
5. Yang Zhou
6. Chun Geun Lee
7. Jack A Elias

• Curated by eLife

  Evaluation Summary:

  The observation that CHI3L1 has the potential to modulate SARS-CoV-2 variants is timely and of potentially great significance. This is a novel approach to treatment and if sufficient additional data can be provided regarding in vivo efficacy this would be of great interest.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript.The reviewers remained anonymous to the authors.)

Reviewed by eLife, ScreenIT

Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish

1. William John Bradshaw
2. Michael Poeschla
3. Aleksandra Placzek
4. Samuel Kean
5. Dario Riccardo Valenzano

• Curated by eLife

  Evaluation Summary:

  This study introduces the killifish as a potential model for immune aging and immunosenescence and characterizes the changes in age-associated immune-repertoire. The authors convincingly show a decrease in diversity of the large expanded B-cell clones that is greater than small clones and a more pronounced change in the intestinal antibody repertoire with age. These results strongly suggest that killifish undergo age-related immunosenescence. Adding functional measures of the immune system would strengthen this conclusion.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling

1. Kai Sun
2. Chun Wang
3. Jianqiu Xiao
4. Michael D Brodt
5. Luorongxin Yuan
6. Tong Yang
7. Yael Alippe
8. Huimin Hu
9. Dingjun Hao
10. Yousef Abu-Amer
11. Matthew J Silva
12. Jie Shen
13. Gabriel Mbalaviele

• Curated by eLife

  Evaluation Summary:

  The paper by Sun et al. addresses the role of gasdermins GSDMD and GSDME in fracture healing and inflammation after injury. The study is very significant for the understanding the role of GSDMD and GSDME in bone homoeostasis and in particular fracture healing. The reported data are very strong and in support of the proposed/studied hypothesis.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles

1. Aniuska Becerra-Artiles
2. J. Mauricio Calvo-Calle
3. Mary Dawn Co
4. Padma P. Nanaware
5. John Cruz
6. Grant C. Weaver
7. Liying Lu
8. Catherine Forconi
9. Robert W. Finberg
10. Ann M. Moormann
11. Lawrence J. Stern

Reviewed by ScreenIT

Macrophage network dynamics depend on haptokinesis for optimal local surveillance

1. Neil Paterson
2. Tim Lämmermann

• Curated by eLife

  Evaluation Summary:

  The role of integrins in macrophage function in tissues is not well understood. Using conditional knockout mice with defective integrin (beta1 and beta2) or talin expression, the authors determine that beta1 integrins and talon are each required for normal morphology and efferocytosis by tissue macrophages. This contrasts with chemotaxis in a 3D environments, which is intact in the absence of integrins, as found for dendritic cells and neutrophils. This is an important finding as it established a molecular mechanism for functional integration of macrophages in diverse tissue microenvironments.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Longitudinal Assessment of SARS-CoV-2 Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multi-Cytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

1. Jonah Lin
2. Ryan Law
3. Chapin S. Korosec
4. Christine Zhou
5. Wan Hon Koh
6. Mohammad Sajjad Ghaemi
7. Philip Samaan
8. Hsu Kiang Ooi
9. FengYun Yue
10. Anne-Claude Gingras
11. Antonio Estacio
12. Megan Buchholz
13. Patti Lou Cheatley
14. Katerina Pavinski
15. Samira Mubareka
16. Allison J. McGeer
17. Jerome A. Leis
18. Jane M. Heffernan
19. Mario Ostrowski

Reviewed by ScreenIT

T Cell Response following Anti-COVID-19 BNT162b2 Vaccination Is Maintained against the SARS-CoV-2 Omicron B.1.1.529 Variant of Concern

1. Hila Cohen
2. Shahar Rotem
3. Uri Elia
4. Gal Bilinsky
5. Itzchak Levy
6. Theodor Chitlaru
7. Erez Bar-Haim

Reviewed by ScreenIT

A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants

1. Jules B. Weinstein
2. Timothy A. Bates
3. Hans C. Leier
4. Savannah K. McBride
5. Eric Barklis
6. Fikadu G. Tafesse

Reviewed by ScreenIT

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

1. Bin Ju
2. Qingbing Zheng
3. Huimin Guo
4. Qing Fan
5. Tingting Li
6. Shuo Song
7. Hui Sun
8. Senlin Shen
9. Xinrong Zhou
10. Lin Cheng
11. Wenhui Xue
12. Lingyan Cui
13. Bing Zhou
14. Xiangyang Ge
15. Haiyan Wang
16. Miao Wang
17. Shaowei Li
18. Ningshao Xia
19. Zheng Zhang

Reviewed by ScreenIT

SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice

1. Katherine S. Lee
2. Ting Y. Wong
3. Brynnan P. Russ
4. Alexander M. Horspool
5. Olivia A. Miller
6. Nathaniel A. Rader
7. Jerome P. Givi
8. Michael T. Winters
9. Zeriel Y. A. Wong
10. Holly A. Cyphert
11. James Denvir
12. Peter Stoilov
13. Mariette Barbier
14. Nadia R. Roan
15. Md. Shahrier Amin
16. Ivan Martinez
17. Justin R. Bevere
18. F. Heath Damron

Reviewed by ScreenIT