Immunology

  1. A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding

    1. Brooke D Huisman
    2. Zheng Dai
    3. David K Gifford
    4. Michael E Birnbaum

    • Curated by eLife

      Evaluation Summary:

      The manuscript builds on previous work to design yeast display libraries representing full viral proteomes with overlapping 15-mer peptides binding to specific HLA-DR alleles, and therefore potentially immunogenic for CD4 T cell responses. The authors use SARS-CoV-2 and dengue viruses as proof of concept and identify a number of potentially immunogenic peptides not predicted by current algorithms. The methods are interesting and promising and will be of interest to a wide range of researchers in immunological and infectious disease studies.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    5 evaluationsAppears in 2 listsLatest version Latest activity

  2. Modeling predicts mechanisms altered by mutations of the SARS-CoV-2 delta and omicron variants

    1. Jason Pearson
    2. Timothy Wessler
    3. Alex Chen
    4. Richard C. Boucher
    5. Ronit Freeman
    6. Samuel K. Lai
    7. Raymond Pickles
    8. M. Gregory Forest

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Pre-clinical testing of two serologically distinct chimpanzee-origin adenovirus vectors expressing spike of SARS-CoV-2

    1. Mikhail Novikov
    2. Mohadeseh Hasanpourghadi
    3. Robert Ambrose
    4. Arezki Chekaoui
    5. Dakota Newman
    6. Wynetta Giles-Davis
    7. Zhiquan Xiang
    8. Xiang Yang Zhou
    9. Hildegund CJ Ertl

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. A SARS-CoV-2 peptide vaccine which elicits T-cell responses in mice but does not protect against infection or disease

    1. Victoria K. Baxter
    2. Elizabeth J. Anderson
    3. Sharon A. Taft-Benz
    4. Kelly Olsen
    5. Maria Sambade
    6. Kaylee M. Gentry
    7. Wolfgang Beck
    8. Jason Garness
    9. Allison Woods
    10. Misha Fini
    11. Brandon Carpenter
    12. Christof C. Smith
    13. Mark T. Heise
    14. Benjamin Vincent
    15. Alex Rubinsteyn

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Mucosal Immunization of Cynomolgus Macaques with Adenoviral Vector Vaccine Elicits Neutralizing Nasal and Serum Antibody to Several SARS-CoV-2 Variants

    1. Becca A. Flitter
    2. Colin A. Lester
    3. Sarah N. Tedjakusuma
    4. Emery G. Dora
    5. Nadine Peinovich
    6. Mario Cortese
    7. Clarissa I. Martinez
    8. Clara B. Jegede
    9. Elena D. Neuhaus
    10. Sean N. Tucker

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses

    1. Dixit Tandel
    2. Vishal Sah
    3. Nitesh Kumar Singh
    4. Poojitha Sai Potharaju
    5. Divya Gupta
    6. Sauhard Shrivastava
    7. Divya Tej Sowpati
    8. Krishnan H Harshan

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Omicron Booster in Ancestral Strain Vaccinated Mice Augments Protective Immunities Against Both Delta and Omicron Variants

    1. Liqiu Jia
    2. Yang Zhou
    3. Shaoshuai Li
    4. Yifan Zhang
    5. Dongmei Yan
    6. Wanhai Wang
    7. Wenhong Zhang
    8. Yanmin Wan
    9. Chao Qiu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules

    1. Stepan Nersisyan
    2. Anton Zhiyanov
    3. Maria Zakharova
    4. Irina Ishina
    5. Inna Kurbatskaia
    6. Azad Mamedov
    7. Alexey Galatenko
    8. Maxim Shkurnikov
    9. Alexander Gabibov
    10. Alexander Tonevitsky

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. SARS-CoV-2 Viroporins Activate The NLRP3-Inflammasome Via The Mitochondrial Permeability Transition Pore

    1. Joseph W. Guarnieri
    2. Alessia Angelin
    3. Deborah G. Murdock
    4. Prasanth Portluri
    5. Timothy Lie
    6. Douglas C. Wallace

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

    1. Rishi R. Goel
    2. Mark M. Painter
    3. Kendall A. Lundgreen
    4. Sokratis A. Apostolidis
    5. Amy E. Baxter
    6. Josephine R. Giles
    7. Divij Mathew
    8. Ajinkya Pattekar
    9. Arnold Reynaldi
    10. David S. Khoury
    11. Sigrid Gouma
    12. Philip Hicks
    13. Sarah Dysinger
    14. Amanda Hicks
    15. Harsh Sharma
    16. Sarah Herring
    17. Scott Korte
    18. Wumesh KC
    19. Derek A. Oldridge
    20. Rachel I. Erickson
    21. Madison E. Weirick
    22. Christopher M. McAllister
    23. Moses Awofolaju
    24. Nicole Tanenbaum
    25. Jeanette Dougherty
    26. Sherea Long
    27. Kurt D’Andrea
    28. Jacob T. Hamilton
    29. Maura McLaughlin
    30. Justine C. Williams
    31. Sharon Adamski
    32. Oliva Kuthuru
    33. Elizabeth M. Drapeau
    34. Miles P. Davenport
    35. Scott E. Hensley
    36. Paul Bates
    37. Allison R. Greenplate
    38. E. John Wherry

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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