Immunology

  1. Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

    1. Shudan Tan
    2. Jinghua Zhao
    3. Xue Hu
    4. Yufeng Li
    5. Zihan Wu
    6. Guoliang Lu
    7. Zhaoli Yu
    8. Binhe Du
    9. Yan Liu
    10. Li Li
    11. Yuchen Chen
    12. Ye Li
    13. Yanfeng Yao
    14. Xiaoyu Zhang
    15. Juhong Rao
    16. Ge Gao
    17. Yun Peng
    18. Hang Liu
    19. Zhiming Yuan
    20. Jia Liu
    21. Qianran Wang
    22. Hengrui Hu
    23. Xiaobo Gao
    24. Hui Zhou
    25. Hang Yu
    26. Yingjie Xu
    27. Wei Yu
    28. Lin Feng
    29. Manli Wang
    30. Chao Shan
    31. Jing Lu
    32. Jinzhong Lin

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Adenovirus-vectored SARS-CoV-2 vaccine expressing S1-N fusion protein

    1. Muhammad S Khan
    2. Eun Kim
    3. Alex McPherson
    4. Florian J Weisel
    5. Shaohua Huang
    6. Thomas W Kenniston
    7. Elena Percivalle
    8. Irene Cassaniti
    9. Fausto Baldanti
    10. Marlies Meisel
    11. Andrea Gambotto

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

    1. Young-Jun Park
    2. Dora Pinto
    3. Alexandra C. Walls
    4. Zhuoming Liu
    5. Anna De Marco
    6. Fabio Benigni
    7. Fabrizia Zatta
    8. Chiara Silacci-Fregni
    9. Jessica Bassi
    10. Kaitlin R. Sprouse
    11. Amin Addetia
    12. John E. Bowen
    13. Cameron Stewart
    14. Martina Giurdanella
    15. Christian Saliba
    16. Barbara Guarino
    17. Michael A. Schmid
    18. Nicholas M. Franko
    19. Jennifer K. Logue
    20. Ha V. Dang
    21. Kevin Hauser
    22. Julia di Iulio
    23. William Rivera
    24. Gretja Schnell
    25. Anushka Rajesh
    26. Jiayi Zhou
    27. Nisar Farhat
    28. Hannah Kaiser
    29. Martin Montiel-Ruiz
    30. Julia Noack
    31. Florian A. Lempp
    32. Javier Janer
    33. Rana Abdelnabi
    34. Piet Maes
    35. Paolo Ferrari
    36. Alessandro Ceschi
    37. Olivier Giannini
    38. Guilherme Dias de Melo
    39. Lauriane Kergoat
    40. Hervé Bourhy
    41. Johan Neyts
    42. Leah Soriaga
    43. Lisa A. Purcell
    44. Gyorgy Snell
    45. Sean P.J. Whelan
    46. Antonio Lanzavecchia
    47. Herbert W. Virgin
    48. Luca Piccoli
    49. Helen Y. Chu
    50. Matteo Samuele Pizzuto
    51. Davide Corti
    52. David Veesler

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Persistent serum protein signatures define an inflammatory subset of long COVID

    1. Aarthi Talla
    2. Suhas V. Vasaikar
    3. Gregory Lee Szeto
    4. Maria P. Lemos
    5. Julie L. Czartoski
    6. Hugh MacMillan
    7. Zoe Moodie
    8. Kristen W. Cohen
    9. Lamar B. Fleming
    10. Zachary Thomson
    11. Lauren Okada
    12. Lynne A. Becker
    13. Ernest M. Coffey
    14. Stephen C. De Rosa
    15. Evan W. Newell
    16. Peter J. Skene
    17. Xiaojun Li
    18. Thomas F. Bumol
    19. M. Juliana McElrath
    20. Troy R. Torgerson

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Delayed antigen-specific CD4 + T-cell induction correlates with impaired immune responses to SARS-COV-2 mRNA vaccination in the elderly

    1. Norihide Jo
    2. Yu Hidaka
    3. Osamu Kikuchi
    4. Masaru Fukahori
    5. Takeshi Sawada
    6. Masahiko Aoki
    7. Masaki Yamamoto
    8. Miki Nagao
    9. Satoshi Morita
    10. Takako E Nakajima
    11. Manabu Muto
    12. Yoko Hamazaki

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Simultaneous and sequential multi-species coronavirus vaccination

    1. Lei Peng
    2. Zhenhao Fang
    3. Paul A. Renauer
    4. Andrew McNamara
    5. Jonathan J. Park
    6. Qianqian Lin
    7. Xiaoyu Zhou
    8. Matthew B. Dong
    9. Biqing Zhu
    10. Hongyu Zhao
    11. Craig B. Wilen
    12. Sidi Chen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Immunological findings in a group of individuals who were non-responders to standard two-dose SARS-CoV-2 vaccines

    1. Qiang Zeng
    2. Xue Yang
    3. Qi Gao
    4. Biao-yang Lin
    5. Yong-zhe Li
    6. Gang Huang
    7. Yang Xu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat

    1. Mengyao Wang
    2. Yu Qi
    3. Yutao Cao
    4. Xiaosheng Zhang
    5. Yongsheng Wang
    6. Qingyou Liu
    7. Jinlong Zhang
    8. Guangbin Zhou
    9. Yue Ai
    10. Shao Wei
    11. Linli Wang
    12. Guoshi Liu
    13. Zhengxing Lian
    14. Hongbing Han

    • Curated by eLife

      Evaluation Summary:

      This study is of interest to animal geneticists studying molecular breeding for infection resistance. The authors provide substantial new insight into the generation of a goat expressing domain fusion receptor TLR2-4, and clarify the mechanism to effectively eliminate S. aureus in macrophages from the gene-edited goat. Taken together, their findings suggest that TLR2-4 knock-in goats can serve as a good animal model for disease resistance breeding.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  9. Structure of the IL-27 quaternary receptor signaling complex

    1. Nathanael A Caveney
    2. Caleb R Glassman
    3. Kevin M Jude
    4. Naotaka Tsutsumi
    5. K Christopher Garcia

    • Curated by eLife

      Evaluation Summary:

      This manuscript is of interest to colleagues in immunity and signal transduction. Cytokines are small protein signaling molecules with a diverse range of activities in inflammation and immune system function. This manuscript reports the cryo-EM structure of the cytokine interleukin-27 (IL-27) bound to soluble domains of two receptor subunits, IL-27Rα and gp130. IL-27 is a composite cytokine consisting of the protein p28 bound to EBI3, which resembles soluble cytokine receptors such as the receptors for IL-6, IL-11 or CNTF. IL-27 signals predominantly via STAT1 and plays an important role in immune homeostasis. The data provide a detailed molecular view of how IL-27 binds to its receptor.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Protection from Omicron and other VOCs by Bivalent S-Trimer COVID-19 Vaccine

    1. Danmei Su
    2. Xinglin Li
    3. Xueqin Huang
    4. Cui He
    5. Cheng Zeng
    6. Qiang Wang
    7. Wenchang Qin
    8. Zhongquan Mu
    9. Donna Ambrosino
    10. George Siber
    11. Ralf Clemens
    12. Joshua G. Liang
    13. Peng Liang
    14. Nick Jackson
    15. Rong Xu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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