Immunology

Structure of the IL-27 quaternary receptor signaling complex

1. Nathanael A Caveney
2. Caleb R Glassman
3. Kevin M Jude
4. Naotaka Tsutsumi
5. K Christopher Garcia

• Curated by eLife

  Evaluation Summary:

  This manuscript is of interest to colleagues in immunity and signal transduction. Cytokines are small protein signaling molecules with a diverse range of activities in inflammation and immune system function. This manuscript reports the cryo-EM structure of the cytokine interleukin-27 (IL-27) bound to soluble domains of two receptor subunits, IL-27Rα and gp130. IL-27 is a composite cytokine consisting of the protein p28 bound to EBI3, which resembles soluble cytokine receptors such as the receptors for IL-6, IL-11 or CNTF. IL-27 signals predominantly via STAT1 and plays an important role in immune homeostasis. The data provide a detailed molecular view of how IL-27 binds to its receptor.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Protection from Omicron and other VOCs by Bivalent S-Trimer COVID-19 Vaccine

1. Danmei Su
2. Xinglin Li
3. Xueqin Huang
4. Cui He
5. Cheng Zeng
6. Qiang Wang
7. Wenchang Qin
8. Zhongquan Mu
9. Donna Ambrosino
10. George Siber
11. Ralf Clemens
12. Joshua G. Liang
13. Peng Liang
14. Nick Jackson
15. Rong Xu

Reviewed by ScreenIT

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9 ⁺ Spp1 ⁺ macrophages promoting viral clearance and inflammation resolution

1. Boyi Cong
2. Xuan Dong
3. Zongheng Yang
4. Pin Yu
5. Yangyang Chai
6. Jiaqi Liu
7. Meihan Zhang
8. Yupeng Zang
9. Jingmin Kang
10. Yu Feng
11. Yi Liu
12. Weimin Feng
13. Wei Deng
14. Fengdi Li
15. Qinyi Yu
16. Yan Gu
17. Zhiqing Li
18. Shuxun Liu
19. Xun Xu
20. Nanshan Zhong
21. Xianwen Ren
22. Chuan Qin
23. Longqi Liu
24. Jian Wang
25. Xuetao Cao

Reviewed by ScreenIT

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

1. Yunlong Cao
2. Ayijiang Yisimayi
3. Fanchong Jian
4. Weiliang Song
5. Tianhe Xiao
6. Lei Wang
7. Shuo Du
8. Jing Wang
9. Qianqian Li
10. Xiaosu Chen
11. Yuanling Yu
12. Peng Wang
13. Zhiying Zhang
14. Pulan Liu
15. Ran An
16. Xiaohua Hao
17. Yao Wang
18. Jing Wang
19. Rui Feng
20. Haiyan Sun
21. Lijuan Zhao
22. Wen Zhang
23. Dong Zhao
24. Jiang Zheng
25. Lingling Yu
26. Can Li
27. Na Zhang
28. Rui Wang
29. Xiao Niu
30. Sijie Yang
31. Xuetao Song
32. Yangyang Chai
33. Ye Hu
34. Yansong Shi
35. Linlin Zheng
36. Zhiqiang Li
37. Qingqing Gu
38. Fei Shao
39. Weijin Huang
40. Ronghua Jin
41. Zhongyang Shen
42. Youchun Wang
43. Xiangxi Wang
44. Junyu Xiao
45. Xiaoliang Sunney Xie

Reviewed by ScreenIT

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

1. Sigrid Wahlen
2. Filip Matthijssens
3. Wouter Van Loocke
4. Sylvie Taveirne
5. Laura Kiekens
6. Eva Persyn
7. Els Van Ammel
8. Zenzi De Vos
9. Stijn De Munter
10. Patrick Matthys
11. Filip Van Nieuwerburgh
12. Tom Taghon
13. Bart Vandekerckhove
14. Pieter Van Vlierberghe
15. Georges Leclercq

Reviewed by Review Commons

Immediate myeloid depot for SARS-CoV-2 in the human lung

1. Mélia Magnen
2. Ran You
3. Arjun A. Rao
4. Ryan T. Davis
5. Lauren Rodriguez
6. Olivier Bernard
7. Camille R. Simoneau
8. Lisiena Hysenaj
9. Kenneth H. Hu
10. Mazharul Maishan
11. Catharina Conrad
12. Oghenekevwe M. Gbenedio
13. Bushra Samad
14. The UCSF COMET Consortium
15. Christina Love
16. Prescott G. Woodruff
17. David J. Erle
18. Carolyn M. Hendrickson
19. Carolyn S. Calfee
20. Michael A. Matthay
21. Jeroen P. Roose
22. Anita Sil
23. Melanie Ott
24. Charles R. Langelier
25. Matthew F. Krummel
26. Mark R. Looney

Reviewed by ScreenIT

Diet induced obesity and type 2 diabetes drives exacerbated sex-associated disease profiles in K18-hACE2-mice challenged with SARS-CoV-2

1. Katherine S. Lee
2. Brynnan P. Russ
3. Ting Y. Wong
4. Alexander M. Horspool
5. Michael T. Winters
6. Mariette Barbier
7. Justin R. Bevere
8. Ivan Martinez
9. F. Heath Damron
10. Holly A. Cyphert

Reviewed by ScreenIT

GM-CSF-activated human dendritic cells promote type1 T follicular helper cells (Tfh1) polarization in a CD40-dependent manner

1. Sarantis Korniotis
2. Melissa Saichi
3. Coline Trichot
4. Caroline Hoffmann
5. Elise Amblard
6. Annick Viguier
7. Sophie Grondin
8. Floriane Noel
9. Hamid Mattoo
10. Vassili Soumelis

Reviewed by ScreenIT

Two types of human TCR differentially regulate reactivity to self and non-self antigens

1. Assya Trofimov
2. Philippe Brouillard
3. Jean-David Larouche
4. Jonathan Séguin
5. Jean-Philippe Laverdure
6. Ann Brasey
7. Gregory Ehx
8. Denis-Claude Roy
9. Lambert Busque
10. Silvy Lachance
11. Sébastien Lemieux
12. Claude Perreault

Reviewed by ScreenIT

Induction of neutralizing antibodies against SARS-CoV-2 variants by a multivalent mRNA-lipid nanoparticle vaccine encoding SARS-CoV-2/SARS-CoV Spike protein receptor-binding domains in mice

1. Qiong Zhang
2. Shashi Tiwari
3. Jing Wen
4. Shaobo Wang
5. Lingling Wang
6. Wanyu Li
7. Lingzhi Zhang
8. Stephen Rawling
9. Yong Cheng
10. Jesse Jokerst
11. Tariq M. Rana

Reviewed by ScreenIT