Immunology

Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV

1. Tongcui Ma
2. Matthew McGregor
3. Leila Giron
4. Guorui Xie
5. Ashley F George
6. Mohamed Abdel-Mohsen
7. Nadia R Roan

• Curated by eLife

  Evaluation Summary:

  This study applies a new novel method of single cell detection to biologically relevant systems to try to understand whether glycans on the surface of CD4+T cells impact HIV susceptibility. They find that cells expressing higher levels of fucose and sialic acid are more likely to be infected with to HIV than those with low levels. The findings point to glycans as a biomarker and potential determinant for HIV cells susceptibility and open the door to new avenues for studies the interplay between cell surface glycans and viral infections.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors

1. Matheswaran Kandasamy
2. Uzi Gileadi
3. Pramila Rijal
4. Tiong Kit Tan
5. Lian N Lee
6. Jili Chen
7. Gennaro Prota
8. Paul Klenerman
9. Alain Townsend
10. Vincenzo Cerundolo

• Curated by eLife

  Evaluation Summary:

  This paper describes an approach in which a non-replicating influenza virus expressing a cancer testis antigen is used to induce a systemic and mucosal antigen specific T cell responses. The authors find that this immune response is sufficient to reduce tumor burden following intravenous or subcutaneous tumor challenge. This paper is potentially interesting to tumor-immunity researchers.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody

1. Sanjeev Kumar
2. Anamika Patel
3. Lilin Lai
4. Chennareddy Chakravarthy
5. Rajesh Valanparambil
6. Elluri Seetharami Reddy
7. Kamalvishnu Gottimukkala
8. Meredith E. Davis-Gardner
9. Venkata Viswanadh Edara
10. Susanne Linderman
11. Kaustuv Nayak
12. Kritika Dixit
13. Pragati Sharma
14. Prashant Bajpai
15. Vanshika Singh
16. Filipp Frank
17. Narayanaiah Cheedarla
18. Hans P. Verkerke
19. Andrew S. Neish
20. John D. Roback
21. Grace Mantus
22. Pawan Kumar Goel
23. Manju Rahi
24. Carl W. Davis
25. Jens Wrammert
26. Sucheta Godbole
27. Amy R. Henry
28. Daniel C. Douek
29. Mehul S. Suthar
30. Rafi Ahmed
31. Eric Ortlund
32. Amit Sharma
33. Kaja Murali-Krishna
34. Anmol Chandele

Reviewed by ScreenIT

Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens

1. Zijun Wang
2. Frauke Muecksch
3. Friederike Muenn
4. Alice Cho
5. Shuai Zong
6. Raphael Raspe
7. Victor Ramos
8. Brianna Johnson
9. Tarek Ben Tanfous
10. Justin DaSilva
11. Eva Bednarski
12. Camila Guzman-Cardozo
13. Martina Turroja
14. Katrina G. Millard
15. Pinkus Tober-Lau
16. David Hillus
17. Kai-Hui Yao
18. Irina Shimeliovich
19. Juan Dizon
20. Anna Kaczynska
21. Mila Jankovic
22. Anna Gazumyan
23. Thiago Y. Oliveira
24. Marina Caskey
25. Paul D. Bieniasz
26. Theodora Hatziioannou
27. Florian Kurth
28. Leif Erik Sander
29. Michel C. Nussenzweig
30. Christian Gaebler

Reviewed by ScreenIT

Three-doses of BNT162b2 COVID-19 mRNA vaccine establishes long-lasting CD8 ⁺ T cell immunity in CLL and MDS patients

1. Susana Patricia Amaya Hernandez
2. Ditte Stampe Hersby
3. Kamilla Kjærgaard Munk
4. Tripti Tamhane
5. Darya Trubach
6. Maria Tagliamonte
7. Luigi Buonaguro
8. Anne Ortved Gang
9. Sine Reker Hadrup
10. Sunil Kumar Saini

Reviewed by ScreenIT

Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-CoV-2 Delta Variant

1. Ke Huang
2. Na Li
3. Yingwen Li
4. Jiafeng Zhu
5. Qianyi Fan
6. Jiali Yang
7. Yinjia Gao
8. Yupin Liu
9. Qiangbo Hou
10. Shufeng Gao
11. Ke Wei
12. Chao Deng
13. Chijian Zuo
14. Zhenhua Sun

Reviewed by ScreenIT

A Mathematical Model of the Within-Host Kinetics of SARS-CoV-2 Neutralizing Antibodies Following COVID-19 Vaccination

1. Lisette de Pillis
2. Rebecca Caffrey
3. Ge Chen
4. Mark D. Dela
5. Leif Eldevik
6. Joseph McConnell
7. Shahrokh Shabahang
8. Stephen A. Varvel

Reviewed by ScreenIT

A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern

1. Mengqi Yuan
2. Xiangyu Chen
3. Yanzhi Zhu
4. Xiaoqing Dong
5. Yan Liu
6. Zhaohui Qian
7. Lilin Ye
8. Pinghuang Liu

Reviewed by ScreenIT

Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron BA.2

1. Runhong Zhou
2. Na Liu
3. Xin Li
4. Qiaoli Peng
5. Cheuk-Kwan Yiu
6. Haode Huang
7. Dawei Yang
8. Zhenglong Du
9. Hau-Yee Kwok
10. Ka-Kit Au
11. Jian-Piao Cai
12. Ivan Fan-Ngai Hung
13. Kelvin Kai-Wang To
14. Xiaoning Xu
15. Kwok-Yung Yuen
16. Zhiwei Chen

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

COVID-19 mRNA third dose induces a unique hybrid immunity-like antibody response

1. Emanuele Andreano
2. Ida Paciello
3. Giulio Pierleoni
4. Giulia Piccini
5. Valentina Abbiento
6. Giada Antonelli
7. Piero Pileri
8. Noemi Manganaro
9. Elisa Pantano
10. Giuseppe Maccari
11. Silvia Marchese
12. Lorena Donnici
13. Linda Benincasa
14. Ginevra Giglioli
15. Margherita Leonardi
16. Concetta De Santi
17. Massimiliano Fabbiani
18. Ilaria Rancan
19. Mario Tumbarello
20. Francesca Montagnani
21. Claudia Sala
22. Duccio Medini
23. Raffaele De Francesco
24. Emanuele Montomoli
25. Rino Rappuoli

Reviewed by ScreenIT