Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
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SciScore for 10.1101/2020.06.13.149039: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study received ethical approval from the East London Research Ethics Committee (study number 11/LL/0229). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Mouse models: 8-10 week old female C57BL/6 mice were used for all studies. Table 2: Resources
Experimental Models: Organisms/Strains Sentences Resources Ifnar−/− mice were bred in house on a C57BL/6 background. C57BL/6suggested: NoneSoftware and Algorithms Sentences Resources All analyses were performed using GraphPad Prism version 8. GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not …
SciScore for 10.1101/2020.06.13.149039: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study received ethical approval from the East London Research Ethics Committee (study number 11/LL/0229). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Mouse models: 8-10 week old female C57BL/6 mice were used for all studies. Table 2: Resources
Experimental Models: Organisms/Strains Sentences Resources Ifnar−/− mice were bred in house on a C57BL/6 background. C57BL/6suggested: NoneSoftware and Algorithms Sentences Resources All analyses were performed using GraphPad Prism version 8. GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
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