Immunology

Circadian rhythms of macrophages are altered by the acidic tumor microenvironment

1. Amelia M Knudsen-Clark
2. Daniel Mwangi
3. Juliana Cazarin
4. Kristina Morris
5. Cameron Baker
6. Lauren M Hablitz
7. Matthew N McCall
8. Minsoo Kim
9. Brian J Altman

Reviewed by Review Commons

Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart

1. Bethany Moyse
2. Joanna Moss
3. Laura Bevan
4. Aaron Scott
5. Valérie Wittamer
6. Rebecca J Richardson

• Curated by eLife

  eLife assessment

  The manuscript presented by Moyse and colleagues provides valuable insight into the origin, morphology, dynamics, and behavior of several populations of mononuclear phagocytes in the zebrafish heart. The study presents solid evidence through the use of transgenic lines and live imaging, although some limitations related to lineage tracing and molecular profiles should be considered. This work exemplifies the use of zebrafish as a model to study the role of leukocytes in cardiac development and regeneration and potentially draw broader interest to biologists working in immunology fields.

Reviewed by eLife

Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

1. Matias A Medina
2. Francisco Fuentes-Villalobos
3. Claudio Quevedo
4. Felipe Aguilera
5. Raul Riquelme
6. Maria Luisa Rioseco
7. Sebastian Barria
8. Yazmin Pinos
9. Mario Calvo
10. Ian Burbulis
11. Camila Kossack
12. Raymond A Alvarez
13. Jose Luis Garrido
14. Maria Ines Barria

• Curated by eLife

  eLife assessment

  This valuable paper compares blood gene signature responses between small cohorts of individuals with mild and severe COVID-19. The authors provide solid evidence for distinct transcriptional profiles during early COVID-19 infections that may be predictive of severity, within the limitations of studying human patients displaying heterogeneity in infection timelines and limited cohort size.

Reviewed by eLife

REL2 overexpression in the Anopheles gambiae midgut causes major transcriptional changes but fails to induce an immune response

1. Astrid Hoermann
2. Paolo Capriotti
3. Giuseppe Del Corsano
4. Maria Grazia Inghilterra
5. Tibebu Habtewold
6. Julia A. Cai
7. Gauri Sachiko Saini
8. Huong Nguyen
9. Nikolai Windbichler
10. George K. Christophides

Reviewed by PREreview

RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

1. Teng-Feng Li
2. Paul Rothhaar
3. Arthur Lang
4. Oliver Grünvogel
5. Ombretta Colasanti
6. Santa Mariela Olivera Ugarte
7. Jannik Traut
8. Antonio Piras
9. Nelson Acosta-Rivero
10. Vladimir Gonçalves Magalhães
11. Emely Springer
12. Andreas Betz
13. Hao-En Huang
14. Jeongbin Park
15. Ruiyue Qiu
16. Gnimah Eva Gnouamozi
17. Ann-Kathrin Mehnert
18. Viet Loan Dao Thi
19. Stephan Urban
20. Martina Muckenthaler
21. Matthias Schlesner
22. Dirk Wohlleber
23. Marco Binder
24. Ralf Bartenschlager
25. Andreas Pichlmair
26. Volker Lohmann

Reviewed by Review Commons

Amphibian mast cells serve as barriers to chytrid fungus infections

1. Kelsey A Hauser
2. Christina N Garvey
3. Ryley S Crow
4. Muhammad RH Hossainey
5. Dustin T Howard
6. Netra Ranganathan
7. Lindsey K Gentry
8. Amulya Yaparla
9. Namarta Kalia
10. Mira Zelle
11. Elizabeth J Jones
12. Anju N Duttargi
13. Louise A Rollins-Smith
14. Carly R Muletz-Wolz
15. Leon Grayfer

• Curated by eLife

  eLife assessment

  This important study reveals the role of skin-resident mast cells in amphibians in mediating antimicrobial responses. The data are compelling and highlight species-specific biology that can cross-inform human mast cell biology in a species that does not rely on IgE as a primary mechanism for antimicrobial skin responses.

Reviewed by eLife

Ixodes ricinus bites promote allergic skin inflammation and intestinal tuft and mast cell expansion in mice

1. Juan Manuel Leyva-Castillo
2. Maria Strakosha
3. Sophia E.M. Smith
4. Daniela Vega-Mendoza
5. Megan Elkins
6. Janet Chou
7. Peter Vogel
8. Nathalie Boulanger

Reviewed by Arcadia Science

Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

1. Hella Luksch
2. Felix Schulze
3. David Geißler-Lösch
4. David Sprott
5. Lennart Höfs
6. Eva M Szegö
7. Wulf Tonnus
8. Stefan Winkler
9. Claudia Günther
10. Andreas Linkermann
11. Rayk Behrendt
12. Lino L Teichmann
13. Björn H Falkenburger
14. Angela Rösen-Wolff

Reviewed by Review Commons

FosB/ΔFosB activation in mast cells regulates gene expression to modulate allergic inflammation in male mice

1. Natalia Duque-Wilckens
2. Dimitri Joseph
3. Meesum Syed
4. Brianna Smith
5. Nidia Maradiaga
6. Szu-Ying Yeh
7. Vidhula Srinivasan
8. Fabiola Sotomayor
9. Kait Durga
10. Eric Nestler
11. Adam J Moesers
12. A.J. Robison

Reviewed by Arcadia Science

Prdm1 positively regulates liver Group 1 ILCs cancer immune surveillance and preserves functional heterogeneity

1. Jitian He
2. Le Gao
3. Peiying Wang
4. Wing Keung Chan
5. Yiran Zheng
6. Yumo Zhang
7. Jiaman Sun
8. Xue Li
9. Jiming Wang
10. Xiao-Hong Li
11. Huaiyong Chen
12. Zhouxin Yang
13. Youwei Wang

• Curated by eLife

  eLife assessment

  The authors investigated the requirement and function of Blimp1/Prdm1 in murine natural killer (NK) cells and the ILC1 lineage of innate lymphoid cells, using a conditional knockout model. The single-cell mRNA-seq data provided here represent a valuable resource for the community, but the lack of mechanistic investigations leaves the study partially incomplete. The work will be of interest to the fields of innate lymphoid cell biology and tissue immunology.

Reviewed by eLife