Immunology

Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens

1. Raphael A. Reyes
2. Louise Turner
3. Isaac Ssewanyana
4. Prasanna Jagannathan
5. Margaret E. Feeney
6. Thomas Lavstsen
7. Bryan Greenhouse
8. Sebastiaan Bol
9. Evelien M. Bunnik

Reviewed by Review Commons

IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection

1. Yaping Chen
2. Pengcheng Zhou
3. Patrick Marc Gubser
4. Yew Ann Leong
5. Jing He
6. Yunbo Wei
7. Fadzai Victor Makota
8. Mehrdad Pazhouhandeh
9. Ting Zheng
10. Joseph Yunis
11. Zhanguo Li
12. Axel Kallies
13. Di Yu

• Curated by eLife

  eLife assessment

  This paper provides valuable findings related to the impact and timing of exogenous interleukin 2 on the balance of exhausted (Tex) versus effector (Teff) that differentiate from precursors T cells (Tpex) during chronic viral infection. While the data appear solid, the overall claims that IL-2 suppresses Tpex are only partially supported, with the rationale for the timing of IL-2 treatment and its underlying mechanisms remaining unclear.

Reviewed by eLife

Inflammation and IL-4 regulate Parkinson’s and Crohn’s disease associated kinase LRRK2

1. Dina Dikovskaya
2. Rebecca Pemberton
3. Matthew Taylor
4. Anna Tasegian
5. Purbasha Bhattacharya
6. Karolina Zeneviciute
7. Esther M Sammler
8. Andrew J M Howden
9. Dario R Alessi
10. Mahima Swamy

Reviewed by Review Commons

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

1. Andrea Cottignies-Calamarte
2. Flora Marteau
3. Feifan He
4. Sandrine Belouzard
5. Jean Dubuisson
6. Daniela Tudor
7. Benoit Viollet
8. Morgane Bomsel

Reviewed by Review Commons