Immunology

Transposable elements regulate thymus development and function

1. Jean-David Larouche
2. Céline M Laumont
3. Assya Trofimov
4. Krystel Vincent
5. Leslie Hesnard
6. Sylvie Brochu
7. Caroline Côté
8. Juliette F Humeau
9. Éric Bonneil
10. Joel Lanoix
11. Chantal Durette
12. Patrick Gendron
13. Jean-Philippe Laverdure
14. Ellen R Richie
15. Sébastien Lemieux
16. Pierre Thibault
17. Claude Perreault

• Curated by eLife

  eLife assessment

  This important study shows, based on analyses of single-cell RNA-seq data sets of thymus cells, that transposable elements (TEs) are broadly expressed in thymic stromal cells, especially in medullary thymic epithelial cells and plasamacytoid dendritic cells. The authors also show that at least some TE-derived peptides are presented by MHC-I molecules in the thymus. The study provides solid findings supporting a role of TEs in thymic T-cell selection and immune self-tolerance.

Reviewed by eLife

Non-canonical NF-κB signaling promotes intestinal inflammation by restraining the tolerogenic β-catenin-Raldh2 axis in dendritic cells

1. Alvina Deka
2. Naveen Kumar
3. Meenakshi Chawla
4. Namrata Bhattacharya
5. Sk Asif Ali
6. Swapnava Basu
7. Bhawna
8. Upasna Madan
9. Shakti Kumar
10. Bhabatosh Das
11. Debarka Sengupta
12. Amit Awasthi
13. Soumen Basak

Reviewed by Review Commons

Pneumocystis murina Promotes Inflammasome Formation and NETosis during Pneumocystis Pneumonia

1. Steven G. Sayson
2. Alan Ashbaugh
3. Aleksey Porollo
4. Melanie T. Cushion

Reviewed by Rapid Reviews Infectious Diseases

Crosstalk between the RNA-binding proteins Regnase-1 and -3 shapes mast cell survival and cytokine expression

1. Marian Bataclan
2. Cristina Leoni
3. Simone G. Moro
4. Matteo Pecoraro
5. Elaine H. Wong
6. Vigo Heissmeyer
7. Silvia Monticelli

Reviewed by Review Commons

Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma

1. Yoshiaki Yasumizu
2. Makoto Kinoshita
3. Martin Jinye Zhang
4. Daisuke Motooka
5. Koichiro Suzuki
6. Daisuke Okuzaki
7. Satoshi Nojima
8. Soichiro Funaki
9. Yasushi Shintani
10. Naganari Ohkura
11. Eiichi Morii
12. Tatsusada Okuno
13. Hideki Mochizuki

Reviewed by preLights

Combining mutation and recombination statistics to infer clonal families in antibody repertoires

1. Natanael Spisak
2. Gabriel Athènes
3. Thomas Dupic
4. Thierry Mora
5. Aleksandra M Walczak

• Curated by eLife

  eLife assessment

  This important study provides a new, apparently high-performance algorithm for B cell clonal family inference. The new algorithm is highly innovative and based on a rigorous probabilistic analysis of the relevant biological processes and their imprint on the resulting sequences, however, the strength of evidence regarding the algorithm's performance is incomplete, due to (1) a lack of clarity regarding how different data sets were used for different steps during algorithm development and validation, resulting in concerns of circularity, (2) a lack of detail regarding the settings for competitor programs during benchmarking, and (3) method development, data simulation for method validation, and empirical analyses all based on the B cell repertoire of a single subject. With clarity around these issues and application to a more diverse set of real samples, this paper could be fundamental to immunologists and important to any researcher or clinician utilizing B cell receptor repertoires in their field (e.g., cancer immunology).

Reviewed by eLife

Semi-synthetic glycoconjugate vaccine candidate against Cryptococcus neoformans

1. Conor J. Crawford
2. Livia Liporagi-Lopes
3. Carolina Coelho
4. Samuel R. Santos Junior
5. André Moraes Nicola
6. Maggie P. Wear
7. Raghav Vij
8. Stefan Oscarson
9. Arturo Casadevall

Reviewed by Rapid Reviews Infectious Diseases

Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

1. Rajan M Thomas
2. Matthew C Pahl
3. Liqing Wang
4. Struan FA Grant
5. Wayne W Hancock
6. Andrew D Wells

• Curated by eLife

  eLife assessment

  This comprehensive study provides valuable information on the cooperation of Ikaros with Foxp3 to establish and regulate a major portion of the epigenome and transcriptome of T-regulatory cells. While the data are compelling, the evidence that these features are solely intrinsic, independent of the micro-environment, could be strengthened.

Reviewed by eLife

Expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice

1. Emily E. Whitaker
2. Neal E. Mecum
3. Riley C. Cott
4. Diana J. Goode

Reviewed by Review Commons

Tribbles1 is host protective during in vivo mycobacterial infection

1. Ffion R Hammond
2. Amy Lewis
3. Gabriele Pollara
4. Gillian S Tomlinson
5. Mahdad Noursadeghi
6. Endre Kiss-Toth
7. Philip M Elks

Reviewed by Review Commons