Immunology

Proximity labeling defines the phagosome lumen proteome of murine and primary human macrophages

1. Benjamin L. Allsup
2. Supriya Gharpure
3. Bryan D. Bryson

Reviewed by Arcadia Science

Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy

1. Mathieu Rouanne
2. Noah Chen
3. Dylan L. Mariuzza
4. Fangda Li
5. Kenia de los Santos-Alexis
6. Thomas M. Savage
7. Rosa L. Vincent
8. Cathy L. Mendelsohn
9. Tal Danino
10. Nicholas Arpaia

Reviewed by PREreview

Inhibition on neutrophil extracellular traps by oligomeric procyanidins alleviate chemotherapy-induced chronic kidney injury via gut-kidney axis

1. Yaqi Luan
2. Weiwei He
3. Kunmao Jiang
4. Shenghui Qiu
5. Lan Jin
6. Xinrui Mao
7. Ying Huang
8. Wentao Liu
9. Jingyuan Cao
10. Lai Jin
11. Rong Wang

• Curated by eLife

  eLife Assessment

  This important study provides evidence for the role of neutrophil extracellular traps in chronic kidney damage (CKD) induced by chemotherapy and suggests a therapeutic approach to mitigate the kidney pathology caused by the NETs. The study utilizes a sound murine in vivo model of CKD with low-dose administration cisplatin and a genetic model for impairment of NET formation by deletion of the enzyme Pad4. In its current form, the study was seen as incomplete as there is not yet formal demonstration of NET production by neutrophils in the model of CKD used. Additionally, the accuracy and clarity of data presentation could be improved.

Reviewed by eLife