Immunology

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor

1. Chenchen Mao
2. Yanyu Chen
3. Dong Xing
4. Teming Zhang
5. Yangxuan Lin
6. Cong Long
7. Jiaye Yu
8. Yunhui Luo
9. Tao Ming
10. Wangkai Xie
11. Zheng Han
12. Dianfeng Mei
13. Dan Xiang
14. Mingdong Lu
15. Xian Shen
16. Xiangyang Xue

• Curated by eLife

  eLife assessment

  This useful study draws on published single-cell and spatial transcriptomic data of colon cancer liver metastasis to clarify the pro- and anti-tumorigenic properties of NK cells. The authors discover increased GZMK+ resting NK cells in the tumor tissue and reduced abundance of KIR2DL4+ activated NK cells. However, the evidence is currently incomplete, as the models used to validate the hypothesis and claims are not adequate and lack the necessary controls.

Reviewed by eLife

Exposure to live saprophytic Leptospira before challenge with a pathogenic serovar prevents severe leptospirosis and promotes kidney homeostasis

1. Suman Kundu
2. Advait Shetty
3. Maria Gomes-Solecki

• Curated by eLife

  eLife assessment

  This important study contributes to our understanding on how prior exposure to a non-pathogenic Leptospira strain could prime the host to prevent severe leptospirosis following infection with a pathogenic strain. The work described is solid and broadly supports the claims, with minor weaknesses that could be addressed in future studies. The work will be of interest to scientists interested in host-pathogen interactions and leptospirosis.

Reviewed by eLife

Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats

1. Axelle Amen
2. Randy Yoo
3. Amanda Fabra-García
4. Judith Bolscher
5. William JR Stone
6. Isabelle Bally
7. Sebastián Dergan-Dylon
8. Iga Kucharska
9. Roos M de Jong
10. Marloes de Bruijni
11. Teun Bousema
12. C Richter King
13. Randall S MacGill
14. Robert W Sauerwein
15. Jean-Philippe Julien
16. Pascal Poignard
17. Matthijs M Jore

• Curated by eLife

  eLife assessment

  This study reports important results and new insights into humoral immune responses to Plasmodium falciparum sexual stage proteins. The experiments are based on the use of target-agnostic memory B cell sorting and screening approaches as well as several state-of-the-art technologies. The authors present compelling evidence that one antibody, B1E11K, is cross-reactive with multiple proteins containing glutamate-rich repeats through homotypic interactions, a process similar to what has been observed for Plasmodium circumsporozoite protein repeat-directed antibodies.

Reviewed by eLife

Transposable elements may enhance antiviral resistance in HIV-1 elite controllers

1. Manvendra Singh
2. Sabrina M. Leddy
3. Luis Pedro Iñiguez
4. Matthew L. Bendall
5. Douglas F. Nixon
6. Cédric Feschotte

Reviewed by Review Commons

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted

1. Miguel Reina-Campos
2. Alexander Monell
3. Amir Ferry
4. Vida Luna
5. Kitty P. Cheung
6. Giovanni Galletti
7. Nicole E. Scharping
8. Kennidy K. Takehara
9. Sara Quon
10. Peter P. Challita
11. Brigid Boland
12. Yun Hsuan Lin
13. William H. Wong
14. Cynthia S. Indralingam
15. Hayley Neadeau
16. Suzie Alarcón
17. Gene W. Yeo
18. John T. Chang
19. Maximilian Heeg
20. Ananda W. Goldrath

Reviewed by preLights

Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

1. Yue Yang
2. Bin Huang
3. Yimeng Qin
4. Danwei Wang
5. Yinuo Jin
6. Linmin Su
7. Qingxin Wang
8. Yi Pan
9. Yanfeng Zhang
10. Yumeng Shen
11. Wenjun Hu
12. Zhengyu Cao
13. Liang Jin
14. Fangfang Zhang

• Curated by eLife

  eLife assessment

  This important study utilizes a comprehensive array of animal and cellular models, alongside various techniques, to elucidate the mechanism by which adipose tissue miR-802 contributes to inflammation and metabolic dysfunction in obesity. The data is solid, with clear, reproducible changes showing low variability among biological replicates and consistency across different models. However, some conclusions should be further substantiated with additional data to enhance the scope and strength of the manuscript.

Reviewed by eLife

Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

1. Youxi Liu
2. Meimei Yin
3. Xiaoting Mao
4. Shuai Wu
5. Shuangping Wei
6. Shujun Heng
7. Yichun Yang
8. Jinwen Huang
9. Zhuolin Guo
10. Chuan Li
11. Chao Ji
12. Liu Hu
13. Wenjie Liu
14. Ling-juan Zhang

• Curated by eLife

  eLife assessment

  This important study uses single-cell RNA-seq to obtain a more granular understanding of cell subsets within allergic contact dermatitis in a model system with DNFB. The convincing data revela unique subpopulations of dermal fibroblasts as key responders to interferon gamma and likely as mediators of dermatitis. This study has many novel aspects and provides a unique resource as well.

Reviewed by eLife

Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens

1. Raphael A. Reyes
2. Louise Turner
3. Isaac Ssewanyana
4. Prasanna Jagannathan
5. Margaret E. Feeney
6. Thomas Lavstsen
7. Bryan Greenhouse
8. Sebastiaan Bol
9. Evelien M. Bunnik

Reviewed by Review Commons

The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice

1. Alexandra a Aybar-Torres
2. Lennon A Saldarriaga
3. Ann T Pham
4. Amir M Emtiazjoo
5. Ashish K Sharma
6. Andrew j Bryant
7. Lei Jin

• Curated by eLife

  eLife assessment

  This study describes useful mouse models of knock-ins of human STING1 variants and an assessment of these variants' action in mouse immune cells. While the implications of the variants in the inflammatory response are of significant interest, limitations are still found in the authors' interpretation and conclusions made, and the evidence for the conclusion remains incomplete.

Reviewed by eLife

CCL28 modulates neutrophil responses during infection with mucosal pathogens

1. Gregory T Walker
2. Araceli Perez-Lopez
3. Steven Silva
4. Michael H Lee
5. Elisabet Bjånes
6. Nicholas Dillon
7. Stephanie L Brandt
8. Romana R Gerner
9. Karine Melchior
10. Grant J Norton
11. Felix A Argueta
12. Frenchesca Dela Pena
13. Lauren Park
14. Victor A Sosa-Hernandez
15. Rodrigo Cervantes-Diaz
16. Sandra Romero-Ramirez
17. Monica Cartelle Gestal
18. Jose L Maravillas-Montero
19. Sean-Paul Nuccio
20. Victor Nizet
21. Manuela Raffatellu

• Curated by eLife

  eLife assessment

  In this study, Perez-Lopez and colleagues examine an important function of the chemokine CCL28 in mucosal host defenses against the gut bacterial pathogen Salmonella Typhimurium and lung pathogen Acinetobacter baumanii. They find that CCL28-CCR3 axis regulates neutrophil recruitment and function, and promotes bacterial clearance in one infectious context but exacerbates disease against the other pathogen. Therefore, CCL28 plays a critical role in mucosal immunity and neutrophil biology that differentially affects host defenses against pathogens.

Reviewed by eLife