Immunology

Monitoring Group Activity of Hamsters and Mice as a Novel Tool to Evaluate COVID-19 Progression, Convalescence, and rVSV-ΔG-Spike Vaccination Efficacy

1. Sharon Melamed
2. Boaz Politi
3. Ettie Grauer
4. Hagit Achdout
5. Moshe Aftalion
6. David Gur
7. Hadas Tamir
8. Yfat Yahalom-Ronen
9. Shlomy Maimon
10. Efi Yitzhak
11. Shay Weiss
12. Amir Rosner
13. Noam Erez
14. Shmuel Yitzhaki
15. Shmuel C Shapira
16. Nir Paran
17. Emanuelle Mamroud
18. Yaron Vagima
19. Tomer Israely

Reviewed by ScreenIT

Safety and potency of BIV1‐CovIran inactivated vaccine candidate for SARS‐CoV‐2: A preclinical study

1. Asghar Abdoli
2. Reza Aalizadeh
3. Hossein Aminianfar
4. Zahra Kianmehr
5. Ali Teimoori
6. Ebrahim Azimi
7. Nabbi Emamipour
8. Marzieh Eghtedardoost
9. Vahid Siavashi
10. Hamidreza Jamshidi
11. Mohammadreza Hosseinpour
12. Mohammad Taqavian
13. Hasan Jalili

Reviewed by ScreenIT

Global Analysis of the Mammalian MHC class I Immunopeptidome at the Organism-Wide Scale

1. Peter Kubiniok
2. Ana Marcu
3. Leon Bichmann
4. Leon Kuchenbecker
5. Heiko Schuster
6. David Hamelin
7. Jérome Despault
8. Kevin Kovalchik
9. Laura Wessling
10. Oliver Kohlbacher
11. Stefan Stevanovic
12. Hans-Georg Rammensee
13. Marian C. Neidert
14. Isabelle Sirois
15. Etienne Caron

• Curated by eLife

  Evaluation Summary:

  Kubiniok et al. use published data sets to bioinformatically study the contribution of tissue type and HLA classical class I gene allotype on the immunopeptidome, the repertoire of peptides presented by MHC class I molecules on the cell surface. This is an understudied and critically important question for understanding CD8+T cell tolerance and immunosurveillance of cancer and other diseased cells and autoimmunity, since it enables accurate prediction of peptide targets for vaccines designed to induce or suppress CD8+ T cell responses. Overall, this is a study that draws attention to some of the properties of the antigen processing and presentation pathway that had not been investigated before, namely the known differential gene expression profiles between tissues resulting in the presentation of tissue-specific antigens on HLA-I molecules, which is very valuable. Additionally this study provides avenues for investigation of the involvement of new enzymatic pathways involved in the generation of HLA-I restricted peptides that are presented to CD8+ T cells for immunosurveillance.

Reviewed by eLife

NCoR1 and SMRT fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling

1. Atimukta Jha
2. Abdul Ahad
3. Gyan Prakash Mishra
4. Kaushik Sen
5. Shuchi Smita
6. Aliva P Minz
7. Viplov Kumar Biswas
8. Archana Tripathy
9. Shanti Bhushan Senapati
10. Bhawna Gupta
11. Hans Acha Orbea
12. Sunil Kumar Raghav

• Curated by eLife

  Evaluation Summary:

  This paper is of interest to immunologists studying the transcriptional control of innate immune responses. The paper presents a new role for transcriptional regulators in the control of inflammatory properties of cross-presenting dendritic cells that are involved in anti-tumoral and anti-viral immunity. The data support the conclusions but some modifications of the text and additional experiments are required.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

1. Peter Radvak
2. Hyung-Joon Kwon
3. Martina Kosikova
4. Uriel Ortega-Rodriguez
5. Ruoxuan Xiang
6. Je-Nie Phue
7. Rong-Fong Shen
8. James Rozzelle
9. Neeraj Kapoor
10. Taylor Rabara
11. Jeff Fairman
12. Hang Xie

Reviewed by ScreenIT

Mapping Potential Antigenic Drift Sites (PADS) on SARS-CoV-2 Spike in Continuous Epitope-Paratope Space

1. Nathaniel L. Miller
2. Thomas Clark
3. Rahul Raman
4. Ram Sasisekharan

Reviewed by ScreenIT

An interactive single cell web portal identifies gene and cell networks in COVID-19 host responses

1. Kang Jin
2. Eric E. Bardes
3. Alexis Mitelpunkt
4. Jake Y. Wang
5. Surbhi Bhatnagar
6. Soma Sengupta
7. Daniel Pomeranz Krummel
8. Marc E. Rothenberg
9. Bruce J. Aronow

Reviewed by ScreenIT

Latent gammaherpesvirus exacerbates arthritis and requires age-associated B cells

1. Isobel C. Mouat
2. Zach J. Morse
3. Iryna Shanina
4. Kelly L. Brown
5. Marc S. Horwitz

• Curated by eLife

  Evaluation Summary:

  This study could help shed light on mechanistic connections between latent infection by EBV with an age-dependent autoimmune condition, such as rheumatoid arthritis. The authors use two models: a murine model of rheumatoid arthritis (CIA), and a murine analog of human EBV: 𝜸HV68. The use of these two models allows the investigation of how latent viral infection exacerbates the autoimmune condition via the action of a special class of B cells: Age-associated B cells.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Immunological Profiling of COVID-19 Patients with Pulmonary Sequelae

1. Jianghua Wu
2. Lu Tang
3. Yanling Ma
4. Yu Li
5. Dongmei Zhang
6. Qian Li
7. Heng Mei
8. Yu Hu

Reviewed by ScreenIT

Pathogenic neutrophilia drives acute respiratory distress syndrome in severe COVID-19 patients

1. Devon J. Eddins
2. Junkai Yang
3. Astrid Kosters
4. Vincent D. Giacalone
5. Ximo Pechuan
6. Joshua D. Chandler
7. Jinyoung Eum
8. Benjamin R. Babcock
9. Brian S. Dobosh
10. Mindy R. Hernández
11. Fathma Abdulkhader
12. Genoah L. Collins
13. Richard P. Ramonell
14. Christine Moussion
15. Darya Y. Orlova
16. Ignacio Sanz
17. F. Eun-Hyung Lee
18. Rabindra M. Tirouvanziam
19. Eliver E.B. Ghosn

Reviewed by ScreenIT