Immunology

Rapid determination of the wide dynamic range of SARS-CoV-2 Spike T cell responses in whole blood of vaccinated and naturally infected

1. Anthony T Tan
2. Joey Ming Er Lim
3. Nina Le Bert
4. Kamini Kunasegaran
5. Adeline Chia
6. Martin Daniel Co Qui
7. Nicole Tan
8. Wan Ni Chia
9. Ruklanthi de Alwis
10. Ding Ying
11. Eng Eong Ooi
12. Lin-Fa Wang
13. Mark I-Cheng Chen
14. Barnaby Young
15. Li Yang Hsu
16. Jenny GH Low
17. David Chien Lye
18. Antonio Bertoletti

Reviewed by ScreenIT

A bacterial extracellular vesicle‐based intranasal vaccine against SARS‐CoV‐2 protects against disease and elicits neutralizing antibodies to wild‐type and Delta variants

1. Linglei Jiang
2. Tom A.P. Driedonks
3. Wouter S.P. Jong
4. Santosh Dhakal
5. H. Bart van den Berg van Saparoea
6. Ioannis Sitaras
7. Ruifeng Zhou
8. Christopher Caputo
9. Kirsten Littlefield
10. Maggie Lowman
11. Mengfei Chen
12. Gabriela Lima
13. Olesia Gololobova
14. Barbara Smith
15. Vasiliki Mahairaki
16. M. Riley Richardson
17. Kathleen R. Mulka
18. Andrew P. Lane
19. Sabra L. Klein
20. Andrew Pekosz
21. Cory Brayton
22. Joseph L. Mankowski
23. Joen Luirink
24. Jason S. Villano
25. Kenneth W. Witwer

Reviewed by ScreenIT

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

1. Dhiraj K. Singh
2. Ekaterina Aladyeva
3. Shibali Das
4. Bindu Singh
5. Ekaterina Esaulova
6. Amanda Swain
7. Mushtaq Ahmed
8. Journey Cole
9. Chivonne Moodley
10. Smriti Mehra
11. Larry S. Schlesinger
12. Maxim N. Artyomov
13. Shabaana A. Khader
14. Deepak Kaushal

Reviewed by ScreenIT

SARS-CoV-2 spike RBD and nucleocapsid encoding DNA vaccine elicits T cell and neutralising antibody responses that cross react with variants

1. VA Brentville
2. M Vankemmelbeke
3. RL Metheringham
4. P Symonds
5. KW Cook
6. RA Urbanowicz
7. T Tsoleridis
8. CM Coleman
9. K-C Chang
10. A Skinner
11. E Dubinina
12. I Daniels
13. S Shah
14. M Argonza
15. J Delgado
16. V Dwivedi
17. V Kulkarni
18. JE Dixon
19. AG Pockley
20. SE Adams
21. SJ Paston
22. JM Daly
23. JK Ball
24. LG Durrant

Reviewed by ScreenIT

Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines

1. José G. Montoya
2. Amy E. Adams
3. Valérie Bonetti
4. Sien Deng
5. Nan A. Link
6. Suzanne Pertsch
7. Kjerstie Olson
8. Martina Li
9. Ellis C. Dillon
10. Dominick L. Frosch

Reviewed by ScreenIT

Probing Affinity, Avidity, Anticooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses

1. Victor Yin
2. Szu-Hsueh Lai
3. Tom G. Caniels
4. Philip J. M. Brouwer
5. Mitch Brinkkemper
6. Yoann Aldon
7. Hejun Liu
8. Meng Yuan
9. Ian A. Wilson
10. Rogier W. Sanders
11. Marit J. van Gils
12. Albert J. R. Heck

Reviewed by ScreenIT

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

1. Daisy X Ji
2. Kristen C Witt
3. Dmitri I Kotov
4. Shally R Margolis
5. Alexander Louie
6. Victoria Chevée
7. Katherine J Chen
8. Moritz M Gaidt
9. Harmandeep S Dhaliwal
10. Angus Y Lee
11. Stephen L Nishimura
12. Dario S Zamboni
13. Igor Kramnik
14. Daniel A Portnoy
15. K Heran Darwin
16. Russell E Vance

• Curated by eLife

  Evaluation Summary:

  Understanding genes that control susceptibility to infection is critically important. In this manuscript Ji et al. identify the gene SP140 as the driving mutation resulting in susceptibility to a range of bacterial pathogens located within the severe susceptibility to tuberculosis (SST1) in mice. While our understanding of how SP140 functions remains unknown, the identification of a single gene within this locus that regulates Type I IFN is impactful and will be of broad interest for immunologists and microbiologists alike.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins

1. Marc Emmenegger
2. Sreedhar Saseendran Kumar
3. Vishalini Emmenegger
4. Tomas Malinauskas
5. Thomas Buettner
6. Laura Rose
7. Peter Schierack
8. Martin F. Sprinzl
9. Clemens J. Sommer
10. Karl J. Lackner
11. Adriano Aguzzi
12. Dirk Roggenbuck
13. Katrin B. M. Frauenknecht

Reviewed by Review Commons, ScreenIT

Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis

1. Maren Kasper
2. Michael Heming
3. David Schafflick
4. Xiaolin Li
5. Tobias Lautwein
6. Melissa Meyer zu Horste
7. Dirk Bauer
8. Karoline Walscheid
9. Heinz Wiendl
10. Karin Loser
11. Arnd Heiligenhaus
12. Gerd Meyer zu Hörste

• Curated by eLife

  Evaluation Summary:

  Kasper et al. have analyzed intra-ocular cells in four subjects with HLA-B27-associated acute anterior uveitis, 2 subjects with HLA-B27-negative anterior uveitis, and one subject with bacterial endophthalmitis using several assay techniques including single cell RNA-Seq, fluorescence activated cell sorting, and quantification of multiple cytokines. They discovered a unique pattern in HLA-B27 positive uveitis that exclusively featured plasmacytoid and classical dendritic cells (cDC) infiltrate and plasma cells. These might provide hints for the pathogenesis of this disease.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

1. Shuaijie Dou
2. Guoxian Li
3. Ge Li
4. Chunmei Hou
5. Yang Zheng
6. Lili Tang
7. Yang Gao
8. Rongliang Mo
9. Yuxiang Li
10. Renxi Wang
11. Beifen Shen
12. Jun Zhang
13. Gencheng Han

• Curated by eLife

  Evaluation Summary:

  Stress granules are a critical component in the defense against certain viruses. The mechanisms regulating stress granules induced but the NF90 pathway are not well defined. Here, the authors use biochemical, cell-based, and in vivo approaches to make the novel discovery that Tim3 functions as a negative regulator of NF90-mediated antiviral responses.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife