Immunology

  1. Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

    1. Dhiraj K. Singh
    2. Ekaterina Aladyeva
    3. Shibali Das
    4. Bindu Singh
    5. Ekaterina Esaulova
    6. Amanda Swain
    7. Mushtaq Ahmed
    8. Journey Cole
    9. Chivonne Moodley
    10. Smriti Mehra
    11. Larry S. Schlesinger
    12. Maxim N. Artyomov
    13. Shabaana A. Khader
    14. Deepak Kaushal

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. SARS-CoV-2 spike RBD and nucleocapsid encoding DNA vaccine elicits T cell and neutralising antibody responses that cross react with variants

    1. VA Brentville
    2. M Vankemmelbeke
    3. RL Metheringham
    4. P Symonds
    5. KW Cook
    6. RA Urbanowicz
    7. T Tsoleridis
    8. CM Coleman
    9. K-C Chang
    10. A Skinner
    11. E Dubinina
    12. I Daniels
    13. S Shah
    14. M Argonza
    15. J Delgado
    16. V Dwivedi
    17. V Kulkarni
    18. JE Dixon
    19. AG Pockley
    20. SE Adams
    21. SJ Paston
    22. JM Daly
    23. JK Ball
    24. LG Durrant

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines

    1. José G. Montoya
    2. Amy E. Adams
    3. Valérie Bonetti
    4. Sien Deng
    5. Nan A. Link
    6. Suzanne Pertsch
    7. Kjerstie Olson
    8. Martina Li
    9. Ellis C. Dillon
    10. Dominick L. Frosch

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Probing Affinity, Avidity, Anticooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses

    1. Victor Yin
    2. Szu-Hsueh Lai
    3. Tom G. Caniels
    4. Philip J. M. Brouwer
    5. Mitch Brinkkemper
    6. Yoann Aldon
    7. Hejun Liu
    8. Meng Yuan
    9. Ian A. Wilson
    10. Rogier W. Sanders
    11. Marit J. van Gils
    12. Albert J. R. Heck

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

    1. Daisy X Ji
    2. Kristen C Witt
    3. Dmitri I Kotov
    4. Shally R Margolis
    5. Alexander Louie
    6. Victoria Chevée
    7. Katherine J Chen
    8. Moritz M Gaidt
    9. Harmandeep S Dhaliwal
    10. Angus Y Lee
    11. Stephen L Nishimura
    12. Dario S Zamboni
    13. Igor Kramnik
    14. Daniel A Portnoy
    15. K Heran Darwin
    16. Russell E Vance

    • Curated by eLife

      Evaluation Summary:

      Understanding genes that control susceptibility to infection is critically important. In this manuscript Ji et al. identify the gene SP140 as the driving mutation resulting in susceptibility to a range of bacterial pathogens located within the severe susceptibility to tuberculosis (SST1) in mice. While our understanding of how SP140 functions remains unknown, the identification of a single gene within this locus that regulates Type I IFN is impactful and will be of broad interest for immunologists and microbiologists alike.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  6. Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins

    1. Marc Emmenegger
    2. Sreedhar Saseendran Kumar
    3. Vishalini Emmenegger
    4. Tomas Malinauskas
    5. Thomas Buettner
    6. Laura Rose
    7. Peter Schierack
    8. Martin F. Sprinzl
    9. Clemens J. Sommer
    10. Karl J. Lackner
    11. Adriano Aguzzi
    12. Dirk Roggenbuck
    13. Katrin B. M. Frauenknecht

    Reviewed by Review Commons, ScreenIT

    4 evaluationsAppears in 2 listsLatest version Latest activity

  7. Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis

    1. Maren Kasper
    2. Michael Heming
    3. David Schafflick
    4. Xiaolin Li
    5. Tobias Lautwein
    6. Melissa Meyer zu Horste
    7. Dirk Bauer
    8. Karoline Walscheid
    9. Heinz Wiendl
    10. Karin Loser
    11. Arnd Heiligenhaus
    12. Gerd Meyer zu Hörste

    • Curated by eLife

      Evaluation Summary:

      Kasper et al. have analyzed intra-ocular cells in four subjects with HLA-B27-associated acute anterior uveitis, 2 subjects with HLA-B27-negative anterior uveitis, and one subject with bacterial endophthalmitis using several assay techniques including single cell RNA-Seq, fluorescence activated cell sorting, and quantification of multiple cytokines. They discovered a unique pattern in HLA-B27 positive uveitis that exclusively featured plasmacytoid and classical dendritic cells (cDC) infiltrate and plasma cells. These might provide hints for the pathogenesis of this disease.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  8. Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

    1. Shuaijie Dou
    2. Guoxian Li
    3. Ge Li
    4. Chunmei Hou
    5. Yang Zheng
    6. Lili Tang
    7. Yang Gao
    8. Rongliang Mo
    9. Yuxiang Li
    10. Renxi Wang
    11. Beifen Shen
    12. Jun Zhang
    13. Gencheng Han

    • Curated by eLife

      Evaluation Summary:

      Stress granules are a critical component in the defense against certain viruses. The mechanisms regulating stress granules induced but the NF90 pathway are not well defined. Here, the authors use biochemical, cell-based, and in vivo approaches to make the novel discovery that Tim3 functions as a negative regulator of NF90-mediated antiviral responses.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  9. Ceylon cinnamon and its major compound Cinnamaldehyde can limit overshooting inflammatory signaling and angiogenesis in vitro : implications for COVID-19 treatment

    1. Kurt Lucas
    2. Maximilian Ackermann
    3. Anna Lena Leifke
    4. William W. Li
    5. Ulrich Pöschl
    6. Janine Fröhlich-Nowoisky

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice

    1. Tianyang Mao
    2. Benjamin Israelow
    3. Carolina Lucas
    4. Chantal B.F. Vogels
    5. Maria Luisa Gomez-Calvo
    6. Olga Fedorova
    7. Mallery I. Breban
    8. Bridget L. Menasche
    9. Huiping Dong
    10. Melissa Linehan
    11. Yale SARS-CoV-2 Genome Surveillance Initiative
    12. Tara Alpert
    13. F. Brito Anderson
    14. Rebecca Earnest
    15. Joseph R. Fauver
    16. Chaney C. Kalinich
    17. Ketty Munyenyembe
    18. Isabel M. Ott
    19. Mary E. Petrone
    20. Jessica Rothman
    21. Anne E. Watkins
    22. Craig B. Wilen
    23. Marie L. Landry
    24. Nathan D. Grubaugh
    25. Anna M. Pyle
    26. Akiko Iwasaki

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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