Probing Affinity, Avidity, Anticooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses
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SciScore for 10.1101/2021.06.18.448939: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources WT and B.1.351 spike proteins, human ACE2 receptor, and antibodies: The 2P-stabilized S proteins of the Wuhan strain (WT) and B.1.351 variant were described previously.12,50 The B.1.351 construct contained the following mutations compared to the WT variant (Wuhan Hu-1; GenBank: MN908947.3): L18F, D80A, D215G, L242H, R246I, K417N, E484K, N501Y, D614G and A701V. human ACE2 receptor,suggested: NoneA701Vsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are …
SciScore for 10.1101/2021.06.18.448939: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources WT and B.1.351 spike proteins, human ACE2 receptor, and antibodies: The 2P-stabilized S proteins of the Wuhan strain (WT) and B.1.351 variant were described previously.12,50 The B.1.351 construct contained the following mutations compared to the WT variant (Wuhan Hu-1; GenBank: MN908947.3): L18F, D80A, D215G, L242H, R246I, K417N, E484K, N501Y, D614G and A701V. human ACE2 receptor,suggested: NoneA701Vsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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