Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines

Article activity feed

1. Version published to 10.1128/spectrum.01162-21

   Dec 22, 2021
2. 

   ScreenIT

   Jul 1, 2021

   SciScore for 10.1101/2021.06.18.449086: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	Consent: Participants: A total of 1,769 clinicians were invited to participate and had to sign the informed consent before enrolling via REDCap.
   Sex as a biological variable	not detected.
   Randomization	Modeling adjusted for age and gender and included a subject-specific random intercept term to account for the within-person correlation of measurements over time.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Participants: A total of 1,769 clinicians were invited to participate and had to sign the informed consent before enrolling via REDCap.	REDCap suggested: (REDCap, RRID:SCR_003445)

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   Results from OddPub: We did not detect open data. We …

   SciScore for 10.1101/2021.06.18.449086: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	Consent: Participants: A total of 1,769 clinicians were invited to participate and had to sign the informed consent before enrolling via REDCap.
   Sex as a biological variable	not detected.
   Randomization	Modeling adjusted for age and gender and included a subject-specific random intercept term to account for the within-person correlation of measurements over time.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Participants: A total of 1,769 clinicians were invited to participate and had to sign the informed consent before enrolling via REDCap.	REDCap suggested: (REDCap, RRID:SCR_003445)

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   Limitations of our paper include that we do not yet have the clinical correlates of immunity that we expect to accrue longitudinally over a minimum of one-year follow-up. Additionally, the clinicians who did not seroconvert due to immunosuppression, did not have measures of T-cell mediated immunity that could still be providing protective immune responses (13). Lastly, this work does not address presence of neutralizing antibodies or antibody responses to other non-mRNA vaccines. SARS-CoV-2 IgG titers against the spike protein are available to clinical laboratories but have not been studied as surrogate markers for immune protection. Measure of quantitative SARS-CoV-2 spike protein IgG responses plotted over time following immunization in specific cohorts, while tracking clinical correlates, may help to identify individuals who have titer levels that become non-protective. This strategy may serve as the basis to have them studied with other correlates of immune protection (e.g. T-cells) (13) or be candidates for additional doses. To achieve these goals (12, 13), only serological assays targeting the spike protein and with demonstrated sensitivity and specificity, such as the one used for our study, ought to be utilized. Ongoing studies such as ours, can potentially unveil differences in IgG responses between vaccine brands (as observed in this interim report) that may be relevant clinically or for manufacturing purposes (e.g., choice of antigen amount).

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • No conflict of interest statement was detected. If there are no conflicts, we encourage authors to explicit state so.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

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   Results from scite Reference Check: We found no unreliable references.

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3. 

   Version published to 10.1101/2021.06.18.449086v1 on bioRxiv

   Jun 19, 2021