Immunology

  1. Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

    1. Daisy X. Ji
    2. Kristen C. Witt
    3. Dmitri I. Kotov
    4. Shally R. Margolis
    5. Alexander Louie
    6. Victoria Chevée
    7. Katherine J. Chen
    8. Moritz Gaidt
    9. Harmandeep S. Dhaliwal
    10. Angus Y. Lee
    11. Stephen Nishimura
    12. Dario S. Zamboni
    13. Igor Kramnik
    14. Daniel A. Portnoy
    15. K. Heran Darwin
    16. Russell E. Vance

    • Curated by eLife

      Evaluation Summary:

      Understanding genes that control susceptibility to infection is critically important. In this manuscript Ji et al. identify the gene SP140 as the driving mutation resulting in susceptibility to a range of bacterial pathogens located within the severe susceptibility to tuberculosis (SST1) in mice. While our understanding of how SP140 functions remains unknown, the identification of a single gene within this locus that regulates Type I IFN is impactful and will be of broad interest for immunologists and microbiologists alike.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins

    1. Marc Emmenegger
    2. Sreedhar Saseendran Kumar
    3. Vishalini Emmenegger
    4. Tomas Malinauskas
    5. Thomas Buettner
    6. Laura Rose
    7. Peter Schierack
    8. Martin F. Sprinzl
    9. Clemens J. Sommer
    10. Karl J. Lackner
    11. Adriano Aguzzi
    12. Dirk Roggenbuck
    13. Katrin B. M. Frauenknecht

    Reviewed by Review Commons, ScreenIT

    4 evaluationsAppears in 2 listsLatest version Latest activity

  3. Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis

    1. Maren Kasper
    2. Michael Heming
    3. David Schafflick
    4. Xiaolin Li
    5. Tobias Lautwein
    6. Melissa Meyer zu Horste
    7. Dirk Bauer
    8. Karoline Walscheid
    9. Heinz Wiendl
    10. Karin Loser
    11. Arnd Heiligenhaus
    12. Gerd Meyer zu Hörste

    • Curated by eLife

      Evaluation Summary:

      Kasper et al. have analyzed intra-ocular cells in four subjects with HLA-B27-associated acute anterior uveitis, 2 subjects with HLA-B27-negative anterior uveitis, and one subject with bacterial endophthalmitis using several assay techniques including single cell RNA-Seq, fluorescence activated cell sorting, and quantification of multiple cytokines. They discovered a unique pattern in HLA-B27 positive uveitis that exclusively featured plasmacytoid and classical dendritic cells (cDC) infiltrate and plasma cells. These might provide hints for the pathogenesis of this disease.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

    1. Shuaijie Dou
    2. Guoxian Li
    3. Ge Li
    4. Chunmei Hou
    5. Yang Zheng
    6. Lili Tang
    7. Yang Gao
    8. Rongliang Mo
    9. Yuxiang Li
    10. Renxi Wang
    11. Beifen Shen
    12. Jun Zhang
    13. Gencheng Han

    • Curated by eLife

      Evaluation Summary:

      Stress granules are a critical component in the defense against certain viruses. The mechanisms regulating stress granules induced but the NF90 pathway are not well defined. Here, the authors use biochemical, cell-based, and in vivo approaches to make the novel discovery that Tim3 functions as a negative regulator of NF90-mediated antiviral responses.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  5. Ceylon cinnamon and its major compound Cinnamaldehyde can limit overshooting inflammatory signaling and angiogenesis in vitro : implications for COVID-19 treatment

    1. Kurt Lucas
    2. Maximilian Ackermann
    3. Anna Lena Leifke
    4. William W. Li
    5. Ulrich Pöschl
    6. Janine Fröhlich-Nowoisky

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice

    1. Tianyang Mao
    2. Benjamin Israelow
    3. Carolina Lucas
    4. Chantal B.F. Vogels
    5. Maria Luisa Gomez-Calvo
    6. Olga Fedorova
    7. Mallery I. Breban
    8. Bridget L. Menasche
    9. Huiping Dong
    10. Melissa Linehan
    11. Yale SARS-CoV-2 Genome Surveillance Initiative
    12. Tara Alpert
    13. F. Brito Anderson
    14. Rebecca Earnest
    15. Joseph R. Fauver
    16. Chaney C. Kalinich
    17. Ketty Munyenyembe
    18. Isabel M. Ott
    19. Mary E. Petrone
    20. Jessica Rothman
    21. Anne E. Watkins
    22. Craig B. Wilen
    23. Marie L. Landry
    24. Nathan D. Grubaugh
    25. Anna M. Pyle
    26. Akiko Iwasaki

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Memory B cells control SARS-CoV-2 variants upon mRNA vaccination of naive and COVID-19 recovered individuals

    1. Aurélien Sokal
    2. Giovanna Barba-Spaeth
    3. Ignacio Fernández
    4. Matteo Broketa
    5. Imane Azzaoui
    6. Andrea de La Selle
    7. Alexis Vandenberghe
    8. Slim Fourati
    9. Anais Roeser
    10. Annalisa Meola
    11. Magali Bouvier-Alias
    12. Etienne Crickx
    13. Laetitia Languille
    14. Marc Michel
    15. Bertrand Godeau
    16. Sébastien Gallien
    17. Giovanna Melica
    18. Yann Nguyen
    19. Virginie Zarrouk
    20. Florence Canoui-Poitrine
    21. France Noizat-Pirenne
    22. Jérôme Megret
    23. Jean-Michel Pawlotsky
    24. Simon Fillatreau
    25. Pierre Bruhns
    26. Felix A. Rey
    27. Jean-Claude Weill
    28. Claude-Agnès Reynaud
    29. Pascal Chappert
    30. Matthieu Mahévas

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters

    1. Kathryn McGuckin Wuertz
    2. Erica K. Barkei
    3. Wei-Hung Chen
    4. Elizabeth J. Martinez
    5. Ines Lakhal-Naouar
    6. Linda L. Jagodzinski
    7. Dominic Paquin-Proulx
    8. Gregory D. Gromowski
    9. Isabella Swafford
    10. Akshaya Ganesh
    11. Ming Dong
    12. Xiankun Zeng
    13. Paul V. Thomas
    14. Rajeshwer S. Sankhala
    15. Agnes Hajduczki
    16. Caroline E. Peterson
    17. Caitlin Kuklis
    18. Sandrine Soman
    19. Lindsay Wieczorek
    20. Michelle Zemil
    21. Alexander Anderson
    22. Janice Darden
    23. Heather Hernandez
    24. Hannah Grove
    25. Vincent Dussupt
    26. Holly Hack
    27. Rafael de la Barrera
    28. Stasya Zarling
    29. James F. Wood
    30. Jeffrey W. Froude
    31. Matthew Gagne
    32. Amy R. Henry
    33. Elham Bayat Mokhtari
    34. Prakriti Mudvari
    35. Shelly J. Krebs
    36. Andrew S. Pekosz
    37. Jeffrey R. Currier
    38. Swagata Kar
    39. Maciel Porto
    40. Adrienne Winn
    41. Kamil Radzyminski
    42. Mark G. Lewis
    43. Sandhya Vasan
    44. Mehul Suthar
    45. Victoria R. Polonis
    46. Gary R. Matyas
    47. Eli A. Boritz
    48. Daniel C. Douek
    49. Robert A. Seder
    50. Sharon P. Daye
    51. Mangala Rao
    52. Sheila A. Peel
    53. M. Gordon Joyce
    54. Diane L. Bolton
    55. Nelson L. Michael
    56. Kayvon Modjarrad

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Increased sensitivity of SARS-CoV-2 to type III interferon in human intestinal epithelial cells

    1. Carmon Kee
    2. Camila Metz-Zumaran
    3. Patricio Doldan
    4. Cuncai Guo
    5. Megan L. Stanifer
    6. Steeve Boulant

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantation

    1. Sajad Moshkelgosha
    2. Allen Duong
    3. Gavin Wilson
    4. Tallulah Andrews
    5. Gregory Berra
    6. Benjamin Renaud-Picard
    7. Mingyao Liu
    8. Shaf Keshavjee
    9. Sonya MacParland
    10. Jonathan Yeung
    11. Tereza Martinu
    12. Stephen Juvet

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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