Immunology

Thymic self-recognition-mediated TCR signal strength modulates antigen- specific CD8+ T cell pathogenicity in non-obese diabetic mice

1. Chia-Lo Ho
2. Li-Tzu Yeh
3. Yu-Wen Liu
4. Jia-Ling Dong
5. Huey-Kang Sytwu

• Curated by eLife

  eLife Assessment

  This valuable study addresses T cell receptor activation during autoreactive T cell development and how the strength of T cell receptor engagement in naïve cells can predispose T cells to develop into effector/memory T cells. The authors lead with solid results that are largely consistent with data in the field suggesting that, in comparison to their counterparts with relatively lower basal self-reactivity, naive CD5hi CD8 T cells in non-obese diabetic (NOD) mice are poised for activation. They propose that diabetogenic T cells are preferentially found among the naive CD5hi CD8 T cell population. While the evidence does not fully support all the authors' conclusions, the data provide a foundation that sets up future studies.

Reviewed by eLife

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8 ⁺ T cells underlies distinct functional potential

1. Simone L. Park
2. Mark M. Painter
3. Sasikanth Manne
4. Victor Alcalde
5. Maura McLaughlin
6. Matthew A. Sullivan
7. Divij Mathew
8. Leonel Torres
9. Yinghui J. Huang
10. David B. Reeg
11. Naomi R. Douek
12. Trenton Campos
13. Max Klapholz
14. Maria A. Cardenas
15. Victoria Fang
16. Shin Foong Ngiow
17. KC Wumesh
18. Rishi R. Goel
19. Amy E. Baxter
20. Jennifer E. Wu
21. Melody Tan
22. Corbett T. Berry
23. Christoph T. Ellebrecht
24. Alexander C. Huang
25. Emily Papazian
26. Ying Liu
27. Karthik Rajasekaran
28. Robert M. Brody
29. Erica R. Thaler
30. Devraj Basu
31. Ahmed Diab
32. Josephine R. Giles
33. E. John Wherry

Reviewed by PREreview

HIV-1 Envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane

1. Adriana Quijada-Freire
2. César A. Santiago
3. Eva Mª García-Cuesta
4. Blanca Soler-Palacios
5. Rosa Ayala-Bueno
6. Sofía R. Gardeta
7. Enara San Sebastian
8. Eva Armendariz-Burgoa
9. María C. Puertas
10. Ricardo Villares
11. Urtzi Garaigorta
12. Luis Ignacio González-Granado
13. José Miguel Rodríguez-Frade
14. Jakub Chojnacki
15. Javier Martinez-Picado
16. Mario Mellado

Reviewed by Review Commons

Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states

1. Riley D.Z. Mullins
2. Jesse Zaretsky
3. Emily Stoller
4. Michael Moore
5. Oliver Takacsi-Nagy
6. Oleg Shpynov
7. Remi Sampaleanu
8. Theodore L. Roth
9. Ansuman T. Satpathy
10. Robi D. Mitra
11. Sidharth V. Puram

Reviewed by preLights

Skin-derived G-CSF activates pathological granulopoiesis upon psoriasis

1. Tomson Kosasih
2. Tatsuya Morishima
3. Sohyeon Lee
4. Jungyeon Yoon
5. Kanako Wakahashi
6. Pilhan Kim
7. Aiko Sada
8. Hitoshi Takizawa

Reviewed by Review Commons

Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancer

1. Baolin Liu
2. Kaichao Feng
3. Kezhuo Yu
4. Ranran Gao
5. Xueda Hu
6. Boyu Qin
7. Jinliang Wang
8. Zhiqiang Xue
9. Weidong Han
10. Zemin Zhang

Reviewed by PREreview

Serratia marcescens Outer Membrane Vesicles rapidly paralyze Drosophila melanogaster through triggering apoptosis in the nervous system

1. Bechara Sina Rahme
2. Roberto E Bruna
3. Marion Draheim
4. Chuping Cai
5. Maria Victoria Molino
6. Yaotang Wu
7. Miriam Wennida Yamba
8. Gisela Di Venanzio
9. Matthieu Lestradet
10. Eleonora García Véscovi
11. Dominique Ferrandon

• Curated by eLife

  eLife Assessment

  This study offers important insights into how outer membrane vesicles (OMVs) secreted by Serratia marcescens, which carry various virulence factors, contribute to pathogenicity. The experiments provide solid preliminary support for OMV-mediated pathogenic effects, with a critical role for the metalloprotease virulence factor PrtA. However, the evidence remains incomplete, and the current level of validation limits confidence in the strength of the conclusions.

Reviewed by eLife

Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells

1. Rita Berkachy
2. Vishwas Mishra
3. Priyanka Biswas
4. Gad Frankel

Reviewed by preLights

Epigenetic Adaptation Drives Monocyte Differentiation into Microglia-Like Cells Upon Engraftment into the Central Nervous System

1. Jie Liu
2. Fengyang Lei
3. Bin Yan
4. Tian Cao
5. Naiwen Cui
6. Jyoti Sharma
7. Victor Correa
8. Lara Roach
9. Savvas Nicolaou
10. Kristen Pitts
11. James Chodosh
12. Daniel E Maidana
13. Demetrios Vavvas
14. Milica A Margeta
15. Huidan Zhang
16. David Weitz
17. Raul Mostoslavsky
18. Eleftherios I Paschalis

• Curated by eLife

  eLife Assessment

  The authors investigated the epigenetic mechanisms regulating the differentiation of circulating monocytes that infiltrate the CNS and adopt microglia-like characteristics. The work is useful to the field, as the contribution of circulating myeloid cell-derived microglia remains controversial. However, the evidence presented is inadequate as the analyses are based on a very limited set of genes, which does not sufficiently support the authors' central claims.

Reviewed by PREreview, eLife

Gut microbial composition modulates food-specific CD4 ⁺ T cells in food allergy

1. Alexa R Weingarden
2. Flannery S Dahlberg
3. Caroline N Broude
4. Xiandong Meng
5. Sunit Jain
6. Allison M Weakley
7. Ashley V Cabrera
8. Thamotharampillai Dileepan
9. Michael A Fischbach
10. Marc K Jenkins

Reviewed by preLights