Immunology

Correlates of protection against African swine fever virus identified by a systems immunology approach

1. Kirill Lotonin
2. Francisco Brito
3. Kemal Mehinagic
4. Obdulio García-Nicolás
5. Matthias Liniger
6. Noelle Donzé
7. Sylvie Python
8. Stephanie Talker
9. Tosca Ploegaert
10. Nicolas Ruggli
11. Charaf Benarafa
12. Artur Summerfield

• Curated by eLife

  eLife Assessment

  This study provides valuable findings regarding potential correlates of protection against the African swine fever virus. The evidence supporting the claims is solid, although analysis using a higher number of animals and other virus strains will be required to further evaluate the relevance of the immune parameters associated to protection. The work will be of broad interest to veterinary immunologists, and particularly those working on African swine fever.

Reviewed by eLife

Single molecule imaging of transcription dynamics, RNA localization and fate in human T cells

1. M. Valeria Lattanzio
2. Nikolina Šoštarić
3. Nandhini Kanagasabesan
4. Branka Popović
5. Antonia Bradarić
6. Leyma Wardak
7. Aurélie Guislain
8. Philipp Savakis
9. Evelina Tutucci
10. Monika C. Wolkers

Reviewed by Review Commons

A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies

1. Thomas Balligand
2. Claire Carpenet
3. Sergi Olive-Palau
4. Tom Jaspers
5. Pavana Suresh
6. Xin Liu
7. Himadri Medhi
8. Yoon Ho Lee
9. Mohammad Rashidian
10. Bart De Strooper
11. Hidde L Ploegh
12. Maarten Dewilde

• Curated by eLife

  eLife Assessment

  In this highly innovative study, Carpenet C et al explore the use of nanobody-based PET imaging to track proliferative cells after in vivo transplantation in mice, in a fully immunocompetent setting. The development of a unique set of PET tracers and mouse strains to track genetically-unmodified transplanted cells in vivo is an important novel asset that could potentially facilitate cell tracking in different research fields. The evidence provided is compelling as the new method proposed might facilitate overcoming certain limitations of alternative approaches, such as full sized immunoglobulins and small molecules.

Reviewed by eLife

Glycosylated IgG antibodies accelerated the recovery of haemorrhagic fever with renal syndrome patients

1. Chuansong Quan
2. Lu Wang
3. Jiming Gao
4. Yaoni Li
5. Xiaoyu Xu
6. Houqiang Li
7. Zixuan Gao
8. Wenxu Ruan
9. Hongzhi Liu
10. Qian Li
11. Weijia Xing
12. Liqiong Zhao
13. Michael J Carr
14. Weifeng Shi
15. Haifeng Hou

• Curated by eLife

  eLife Assessment

  The authors investigated the potential role of IgG N-glycosylation in Haemorrhagic Fever with Renal Syndrome (HFRS), which may offer significant insights for understanding molecular mechanisms and for the development of therapeutic strategies for this infectious disease. The findings are useful to the field, although the strength of evidence to support the findings is incomplete. Several issues need to be addressed, including more detail on the background, methods, and results. Additional statistical tests should be performed, and the conclusions should reflect the correlational findings of the paper.

Reviewed by eLife

Xcr1 ⁺ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

1. Tianhan Li
2. Liaoxun Lu
3. Juanjuan Qiu
4. Xin Dong
5. Le Yang
6. Kexin He
7. Yanrong Gu
8. Binhui Zhou
9. Tingting Jia
10. Toby Lawrence
11. Marie Malissen
12. Guixue Wang
13. Rong Huang
14. Hui Wang
15. Bernard Malissen
16. Yinming Liang
17. Lichen Zhang

• Curated by eLife

  eLife Assessment

  This manuscript by Li, Lu et al., presents important findings on the role of cDC1 in atherosclerosis and their influence on the adaptive immune system. Using Xcr1Cre-Gfp Rosa26LSL-DTA ApoE-/- mouse models, these data convincingly reveal an unexpected, non-redundant role of the XCL1-XCR1 axis in mediating cDC1 contributions to atherosclerosis.

Reviewed by eLife

Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

1. Wesley H Godfrey
2. Judy J Lee
3. Shruthi Shanmukha
4. Kaho Cho
5. Xiaojing Deng
6. Chandra Shekar R Ambati
7. Vasanta Putluri
8. Abu Hena Mostafa Kamal
9. Paul M Kim
10. Nagireddy Putluri
11. Michael D Kornberg

• Curated by eLife

  eLife Assessment

  This paper highlights an important physiological function of PGAM in the differentiation and suppressive activity of Treg cells by regulating serine synthesis. This role is proposed to intersect with glycolysis and one-carbon metabolism. The study's conclusion is supported by solid evidence from in-vitro cellular and in-vivo mouse models.

Reviewed by eLife

Pediatric cerebrospinal fluid immune profiling distinguishes pediatric-onset multiple sclerosis from other pediatric-onset acute neurological disorders

1. Diego A. Espinoza
2. Tobias Zrzavy
3. Gautier Breville
4. Simon Thebault
5. Amaar Marefi
6. Ina Mexhitaj
7. Luana D. Yamashita
8. Mengyuan Kan
9. Micky Bacchus
10. Jessica Legaspi
11. Samantha Fernandez
12. Anna Melamed
13. Mallory Stubblebine
14. Yeseul Kim
15. Zachary Martinez
16. Caroline Diorio
17. Andreas Schulte-Mecklenbeck
18. Heinz Wiendl
19. Ayman Rezk
20. Rui Li
21. Sona Narula
22. Amy T. Waldman
23. Sarah E. Hopkins
24. Brenda Banwell
25. Amit Bar-Or

Reviewed by preLights

CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

1. Liangliang Fu
2. Chenghu Yin
3. Qin Zhao
4. Shuling Guo
5. Wenjun Shao
6. Ting Xia
7. Quan Sun
8. Liangwen Chen
9. Jinghan Li
10. Min Wang
11. Haibin Xia

• Curated by eLife

  eLife Assessment

  This valuable study identifies a population of CD81-positive fibroblasts showing senescence signatures that can activate neutrophils through the C3/C3aR1 axis, hence contributing to the inflammatory response in periodontitis. Solid evidence, combining in vitro and in vivo analyses and mouse and human data, supports these findings. The revised manuscript has addressed many concerns significantly. The work would be of interest to researchers working in the senescence and oral medicine fields.

Reviewed by eLife

Layilin Regulates Treg Motility and Suppressive Capacity in Skin

1. Victoire Gouirand
2. Sean Clancy
3. Courtney Macon
4. Jose Valle
5. Mariela Pauli
6. Hong-An Troung
7. Jarish Cohen
8. Maxime Kinet
9. Margaret M Lowe
10. Samuel J Lord
11. Kristen Skruber
12. Hobart Harris
13. Esther Kim
14. Isaac Neuhaus
15. Karin Reif
16. Ali A Zarrin
17. Dyche R Mullins
18. Michael D Rosenblum

• Curated by eLife

  eLife Assessment

  This study reports valuable findings on the role of Layilin in the motility and suppressive capacity of clonal expanded regulatory T cells (Tregs) in the skin. Although the strength of the study is utilizing conditional knock-out mice and human skin samples, the analysis of the molecular mechanism by which Layilin affects Treg function is incomplete. The study will be of interest to medical scientists working on skin immunology.

Reviewed by eLife, Arcadia Science

Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention

1. Alisa Sukhina
2. Clemence Queriault
3. Saptarshi Roy
4. Elise Hall
5. Kelly Rome
6. Muskaan Aggarwal
7. Elizabeth Nunn
8. Ashley Weiss
9. Janet Nguyen
10. F Chris Bennett
11. Will Bailis

• Curated by eLife

  eLife Assessment

  This important work advances our understanding of the impact of malnutrition on hematopoiesis and subsequently infection susceptibility. Support for the overall claims is convincing in some respects and incomplete in terms of identifying mechanism as highlighted by reviewers. This work will be of general interest to those in the fields of hematopoiesis, malnutrition, and dietary influence on immunity.

Reviewed by eLife