Immunology

WASp activity in macrophages prevents mechano-induced inflammation by protecting the nuclear envelope

1. Roberto Amadio
2. Giulia Bracchetti
3. Zahraa Alraies
4. Giulia Maria Piperno
5. Lucia Lopez Rodriguez
6. Mathieu Maurin
7. Martina Conti
8. Laura Andolfi
9. Maria Carmina Castiello
10. Francesca Ferrua
11. Anna Villa
12. Alessandro Aiuti
13. Ana-Maria Lennon-Dumenil
14. Federica Benvenuti

Reviewed by Review Commons

Fatty Acid Synthase associates with nuclear-derived cytoplasmic dsRNA molecules and influences antiviral innate immune response

1. Charline Pasquier
2. Mélanie Messmer
3. Lise Moroge
4. Lisanne Knol
5. Johana Chicher
6. Richard Patryk Ngondo
7. Sébastien Pfeffer
8. Erika Girardi

Reviewed by Review Commons

The C3-C3aR axis modulates trained immunity in alveolar macrophages

1. Alexander P Earhart
2. Alberto Lopez
3. Josue I Hernandez
4. Aasritha Nallapu
5. Deebly Chavez
6. Sayahi Suthakaran
7. Brian Yang
8. Jungheun Hyun
9. Rafael Aponte Alburquerque
10. Marick Starick
11. Lorena Garnica
12. Ayse Naz Ozanturk
13. Rahul Kumar Maurya
14. Xiaobo Wu
15. Jeffrey A Haspel
16. Jae Woo Lee
17. Jaime Hook
18. Hrishikesh S Kulkarni

• Curated by eLife

  eLife Assessment

  This study explores how complement protein C3 and its signalling may modulate immune training in alveolar macrophages. The findings are an important contribution to the field of trained immunity. The findings are convincingly supported by in vivo and ex vivo experiments, encompassing both pharmacological and genetic-based approaches.

Reviewed by eLife

Mycobacterium tuberculosis suppresses protective Th17 responses during infection

1. Alex Zilinskas
2. Amir Balakhmet
3. Douglas Fox
4. Heyuan Michael Ni
5. Carolina Agudelo
6. Helia Samani
7. Sarah A Stanley

• Curated by eLife

  eLife Assessment

  This important study investigates the mechanisms by which Mycobacterium tuberculosis suppresses protective Th17 differentiation during infection. Using ESX-1- and PDIM-deficient mutants of M. tuberculosis, which lack functional eccC1 and fadD28 respectively, the authors demonstrate that these virulence factors actively restrict IL-17 responses via a T-bet-dependent pathway, independent of overall bacterial attenuation or infection duration. While the precise molecular interactions by which ESX-1 and PDIM modulate Th17 differentiation warrant further elucidation, the experiments are rigorously designed, the findings are clearly presented, and the evidence is solid for a specific role for these factors in limiting protective IL-17 immunity in M. tuberculosis infection.

Reviewed by eLife

BATF controls IFN I production via DC-SCRIPT in plasmacytoid dendritic cells

1. Shafaqat Ali
2. Ritu Mann-Nüttel
3. Marcel Marson
4. Ben Leiser
5. Jasmina Hoffe
6. Regine J. Dress
7. Mahamudul Hasan Bhuyan
8. Patrick Petzsch
9. Karl Köhrer
10. Haifeng C. Xu
11. Philipp A. Lang
12. Shengbo Zhang
13. Michaël Chopin
14. Stephen L. Nutt
15. Judith Alferink
16. Stefanie Scheu

Reviewed by PREreview

Integrin-deficient T cell leukemia accumulates in the central nervous system

1. Samantha Y Lux
2. Cynthia Chen
3. Bibi S Subhan
4. Hyunsoo Chung
5. Martyna Okuniewska
6. Asha Y Caslin
7. Kathleen A Martin
8. Jennifer K Schiavo
9. Jonah B Vernejoul
10. Robert C Froemke
11. Michael Cammer
12. Susan R Schwab

• Curated by eLife

  eLife Assessment

  This study presents an important finding that loss or blockade of key integrins unexpectedly enhances central nervous system accumulation of T-cell acute lymphoblastic leukemia cells and may increase their sensitivity to chemotherapy. The evidence is convincing, supported by well-designed in vivo models, CRISPR-based perturbations, competitive assays, imaging, and complementary therapeutic experiments. However, the mechanistic basis linking integrin loss, altered spatial distribution, and increased proliferation remains incompletely defined, and the translational implications would be strengthened by additional survival studies and validation in more clinically relevant models.

Reviewed by eLife

The serine protease homolog Skanda modulates Toll-Phenoloxidase-mediated immunity in Drosophila

1. Sanjana Vasanth
2. Yang Wang
3. Nathan Klotz
4. Anzer Khan
5. Chao Xiong
6. Jean-Philippe Boquete
7. Tisheng Shan
8. Prince Kumar Sah
9. Haobo Jiang
10. Bruno Lemaitre

Reviewed by Review Commons

Uncovering the Heterogeneity and Ontogeny of Mouse Thymic Macrophages Reveals an Unexpected Early Checkpoint Role

1. Helen Wang
2. Vinothkumar Rajan
3. Anthony Wong
4. Slava Epelman
5. Juan Carlos Zúñiga-Pflücker

• Curated by eLife

  eLife Assessment

  This study characterizes the heterogeneity and developmental origins of macrophages in the thymus and offers tantalizing evidence of their potential involvement in the first step of T cell selection. The macrophage characterisation is interesting, although the evidence for the specific involvement of macrophages in beta-selection is incomplete, as alternative explanations have not been ruled out. These results provide an important advance that further our understanding of thymus biology, especially in view of the contribution of heterogenous thymic macrophage subpopulations.

Reviewed by eLife