Immunology

UBA1 Mutations Drive RIPK1-Mediated Cell Death and Monocyte Dysfunction in VEXAS Syndrome

1. Paul Breillat
2. Samuel J. Magaziner
3. Stéphane Camus
4. Léa Dionet
5. Benjamin de Valence
6. Pierre Sohier
7. Amine Majdi
8. Quentin Delcros
9. Federica Pallotti
10. Nadia Rivet
11. Kevin Chevalier
12. Margot Poux
13. Pierre-Louis Tharaux
14. Olivia Lenoir
15. Abdelrahim Zoued
16. Olivier Kosmider
17. David B. Beck
18. Benjamin Terrier

Reviewed by PREreview

WASp activity in macrophages prevents mechano-induced inflammation by protecting the nuclear envelope

1. Roberto Amadio
2. Giulia Bracchetti
3. Zahraa Alraies
4. Giulia Maria Piperno
5. Lucia Lopez Rodriguez
6. Mathieu Maurin
7. Martina Conti
8. Laura Andolfi
9. Maria Carmina Castiello
10. Francesca Ferrua
11. Anna Villa
12. Alessandro Aiuti
13. Ana-Maria Lennon-Dumenil
14. Federica Benvenuti

Reviewed by Review Commons

Fatty Acid Synthase associates with nuclear-derived cytoplasmic dsRNA molecules and influences antiviral innate immune response

1. Charline Pasquier
2. Mélanie Messmer
3. Lise Moroge
4. Lisanne Knol
5. Johana Chicher
6. Richard Patryk Ngondo
7. Sébastien Pfeffer
8. Erika Girardi

Reviewed by Review Commons

Mycobacterium tuberculosis suppresses protective Th17 responses during infection

1. Alex Zilinskas
2. Amir Balakhmet
3. Douglas Fox
4. Heyuan Michael Ni
5. Carolina Agudelo
6. Helia Samani
7. Sarah A Stanley

• Curated by eLife

  eLife Assessment

  This important study investigates the mechanisms by which Mycobacterium tuberculosis suppresses protective Th17 differentiation during infection. Using ESX-1- and PDIM-deficient mutants of M. tuberculosis, which lack functional eccC1 and fadD28 respectively, the authors demonstrate that these virulence factors actively restrict IL-17 responses via a T-bet-dependent pathway, independent of overall bacterial attenuation or infection duration. While the precise molecular interactions by which ESX-1 and PDIM modulate Th17 differentiation warrant further elucidation, the experiments are rigorously designed, the findings are clearly presented, and the evidence is solid for a specific role for these factors in limiting protective IL-17 immunity in M. tuberculosis infection.

Reviewed by eLife

BATF controls IFN I production via DC-SCRIPT in plasmacytoid dendritic cells

1. Shafaqat Ali
2. Ritu Mann-Nüttel
3. Marcel Marson
4. Ben Leiser
5. Jasmina Hoffe
6. Regine J. Dress
7. Mahamudul Hasan Bhuyan
8. Patrick Petzsch
9. Karl Köhrer
10. Haifeng C. Xu
11. Philipp A. Lang
12. Shengbo Zhang
13. Michaël Chopin
14. Stephen L. Nutt
15. Judith Alferink
16. Stefanie Scheu

Reviewed by PREreview