Immunology

Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states

1. Riley D.Z. Mullins
2. Jesse Zaretsky
3. Emily Stoller
4. Michael Moore
5. Oliver Takacsi-Nagy
6. Oleg Shpynov
7. Remi Sampaleanu
8. Theodore L. Roth
9. Ansuman T. Satpathy
10. Robi D. Mitra
11. Sidharth V. Puram

Reviewed by preLights

Skin-derived G-CSF activates pathological granulopoiesis upon psoriasis

1. Tomson Kosasih
2. Tatsuya Morishima
3. Sohyeon Lee
4. Jungyeon Yoon
5. Kanako Wakahashi
6. Pilhan Kim
7. Aiko Sada
8. Hitoshi Takizawa

Reviewed by Review Commons

Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancer

1. Baolin Liu
2. Kaichao Feng
3. Kezhuo Yu
4. Ranran Gao
5. Xueda Hu
6. Boyu Qin
7. Jinliang Wang
8. Zhiqiang Xue
9. Weidong Han
10. Zemin Zhang

Reviewed by PREreview

Serratia marcescens Outer Membrane Vesicles rapidly paralyze Drosophila melanogaster through triggering apoptosis in the nervous system

1. Bechara Sina Rahme
2. Roberto E Bruna
3. Marion Draheim
4. Chuping Cai
5. Maria Victoria Molino
6. Yaotang Wu
7. Miriam Wennida Yamba
8. Gisela Di Venanzio
9. Matthieu Lestradet
10. Eleonora García Véscovi
11. Dominique Ferrandon

• Curated by eLife

  eLife Assessment

  This study offers important insights into how outer membrane vesicles (OMVs) secreted by Serratia marcescens, which carry various virulence factors, contribute to pathogenicity. The experiments provide solid preliminary support for OMV-mediated pathogenic effects, with a critical role for the metalloprotease virulence factor PrtA. However, the evidence remains incomplete, and the current level of validation limits confidence in the strength of the conclusions.

Reviewed by eLife

Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells

1. Rita Berkachy
2. Vishwas Mishra
3. Priyanka Biswas
4. Gad Frankel

Reviewed by preLights

Epigenetic Adaptation Drives Monocyte Differentiation into Microglia-Like Cells Upon Engraftment into the Central Nervous System

1. Jie Liu
2. Fengyang Lei
3. Bin Yan
4. Tian Cao
5. Naiwen Cui
6. Jyoti Sharma
7. Victor Correa
8. Lara Roach
9. Savvas Nicolaou
10. Kristen Pitts
11. James Chodosh
12. Daniel E Maidana
13. Demetrios Vavvas
14. Milica A Margeta
15. Huidan Zhang
16. David Weitz
17. Raul Mostoslavsky
18. Eleftherios I Paschalis

• Curated by eLife

  eLife Assessment

  The authors investigated the epigenetic mechanisms regulating the differentiation of circulating monocytes that infiltrate the CNS and adopt microglia-like characteristics. The work is useful to the field, as the contribution of circulating myeloid cell-derived microglia remains controversial. However, the evidence presented is inadequate as the analyses are based on a very limited set of genes, which does not sufficiently support the authors' central claims.

Reviewed by PREreview, eLife

Gut microbial composition modulates food-specific CD4 ⁺ T cells in food allergy

1. Alexa R Weingarden
2. Flannery S Dahlberg
3. Caroline N Broude
4. Xiandong Meng
5. Sunit Jain
6. Allison M Weakley
7. Ashley V Cabrera
8. Thamotharampillai Dileepan
9. Michael A Fischbach
10. Marc K Jenkins

Reviewed by preLights

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

1. Long-Feng Lu
2. Can Zhang
3. Zhuo-Cong Li
4. Bao-Jie Cui
5. Yang-Yang Wang
6. Ke-Jia Han
7. Xiao Xu
8. Chu-Jing Zhou
9. Xiao-Yu Zhou
10. Yue Wu
11. Na Xu
12. Xiao-Li Yang
13. Dan-Dan Chen
14. Xi-Yin Li
15. Li Zhou
16. Shun Li

• Curated by eLife

  eLife Assessment

  This valuable study uses zebrafish as a model to reveal a role for the cell cycle protein kinase CDK2 as a negative regulator of type I interferon signaling. The evidence supporting the authors' claims is convincing, including both in vivo and in vitro investigative approaches that corroborate a role for CDK2 in regulating TBK1 degradation. In this latest version, the authors included data addressing a concern raised by the reviewer in the previous peer review round. This work will interest cell biologists, immunologists, and virologists.

Reviewed by eLife

Glycosylated IgG antibodies contribute to the recovery of haemorrhagic fever with renal syndrome patients

1. Chuansong Quan
2. Lu Wang
3. Jiming Gao
4. Yaoni Li
5. Xiaoyu Xu
6. Houqiang Li
7. Zixuan Gao
8. Wenxu Ruan
9. Hongzhi Liu
10. Qian Li
11. Weijia Xing
12. Liqiong Zhao
13. Michael J Carr
14. Weifeng Shi
15. Haifeng Hou

• Curated by eLife

  eLife Assessment

  The authors investigated the potential role of IgG N-glycosylation in Haemorrhagic Fever with Renal Syndrome (HFRS), which may offer significant insights for understanding molecular mechanisms and for the development of therapeutic strategies for this infectious disease. The findings are valuable to the field and the strength of evidence to support the findings is solid.

Reviewed by eLife

Phospholipid Scramblase 1 (PLSCR1) Regulates Interferon-Lambda Receptor 1 (IFN-λR1) and IFN-λ Signaling in Influenza A Virus (IAV) Infection

1. Alina X Yang
2. Lisa Ramos-Rodriguez
3. Parand Sorkhdini
4. Dongqin Yang
5. Carmelissa Norbrun
6. Sonoor Majid
7. Sanghyun Lee
8. Yong Zhang
9. Michael J Holtzman
10. David F Boyd
11. Yang Zhou

• Curated by eLife

  eLife Assessment

  This valuable manuscript presents a potentially novel mechanism by which the phospholipid scramblase, PLSCR1, defends against influenza A virus infection. The strength of the paper rests on solid findings involving knockout and lung specific over-expressing Plscr1 mice, airway tissue expression and mechanistic studies to show Plscr1 enhances type III interferon-mediated viral clearance.

Reviewed by eLife