1. Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

    This article has 16 authors:
    1. Long-Feng Lu
    2. Can Zhang
    3. Zhuo-Cong Li
    4. Bao-Jie Cui
    5. Yang-Yang Wang
    6. Ke-Jia Han
    7. Xiao Xu
    8. Chu-Jing Zhou
    9. Xiao-Yu Zhou
    10. Yue Wu
    11. Na Xu
    12. Xiao-Li Yang
    13. Dan-Dan Chen
    14. Xi-Yin Li
    15. Li Zhou
    16. Shun Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study makes a valuable contribution to understanding antiviral responses in fish by revealing a role for the cell cycle protein kinase CDK2 in type I interferon signaling. The evidence supporting the authors' claims is solid, including both in vivo and in vitro investigative approaches. However, the mechanisms underlying CDK2 activity are not completely established. This work will be of interest to cell biologists, immunologists, and virologists.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart

    This article has 6 authors:
    1. Bethany Moyse
    2. Joanna Moss
    3. Laura Bevan
    4. Aaron Scott
    5. Valérie Wittamer
    6. Rebecca J. Richardson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript presented by Moyse and colleagues provides valuable insight into the origin, morphology, dynamics, and behavior of several populations of mononuclear phagocytes in the zebrafish heart. The study presents solid evidence through the use of transgenic lines and live imaging, although some limitations related to lineage tracing and molecular profiles should be considered. This work exemplifies the use of zebrafish as a model to study the role of leukocytes in cardiac development and regeneration and potentially draw broader interest to biologists working in immunology fields.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

    This article has 15 authors:
    1. Matias A. Medina
    2. Francisco Fuentes-Villalobos
    3. Claudio Quevedo
    4. Felipe Aguilera
    5. Raul Riquelme
    6. Maria Luisa Rioseco
    7. Sebastian Barria
    8. Yazmin Pinos
    9. Mario Calvo
    10. Ian Burbulis
    11. Camila Kossack
    12. Raymond A Alvarez
    13. COVID 19 South Chile Group
    14. Jose Luis Garrido
    15. Maria Ines Barria
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable paper compares blood gene signature responses between small cohorts of individuals with mild and severe COVID-19. The authors provide solid evidence for distinct transcriptional profiles during early COVID-19 infections that may be predictive of severity, within the limitations of studying human patients displaying heterogeneity in infection timelines and limited cohort size.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  4. Broadly inhibitory antibodies against severe malaria virulence proteins

    This article has 25 authors:
    1. Raphael A. Reyes
    2. Sai Sundar Rajan Raghavan
    3. Nicholas K. Hurlburt
    4. Viola Introini
    5. Ikhlaq Hussain Kana
    6. Rasmus W. Jensen
    7. Elizabeth Martinez-Scholze
    8. Maria Gestal-Mato
    9. Cristina Bancells Bau
    10. Monica Lisa Fernández-Quintero
    11. Johannes R. Loeffler
    12. James Alexander Ferguson
    13. Wen-Hsin Lee
    14. Greg Michael Martin
    15. Thor G. Theander
    16. Isaac Ssewanyana
    17. Margaret E. Feeney
    18. Bryan Greenhouse
    19. Sebastiaan Bol
    20. Andrew B. Ward
    21. Maria Bernabeu
    22. Marie Pancera
    23. Louise Turner
    24. Evelien M. Bunnik
    25. Thomas Lavstsen

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. PIM kinase control of CD8 T cell protein synthesis and cell trafficking

    This article has 4 authors:
    1. Julia M Marchingo
    2. Laura Spinelli
    3. Shalini Pathak
    4. Doreen A Cantrell
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important study, as PIM1/2 control of protein synthesis in differentiated cells has implications beyond T cells. The evidence is convincing in that it makes extensive use of the mouse knockout model and validation in mouse T cells with inhibitors. A rescue experiment in mouse KO T cells would be even stronger than the inhibitor studies to validate the KO phenotype and the evidence would be truly impressive if the results from the rescue experiment support the working model. Extending the observations to human T cells would also be a step towards translation and would further increase the potential impact of the work.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. REL2 overexpression in the Anopheles gambiae midgut causes major transcriptional changes but fails to induce an immune response

    This article has 10 authors:
    1. Astrid Hoermann
    2. Paolo Capriotti
    3. Giuseppe Del Corsano
    4. Maria Grazia Inghilterra
    5. Tibebu Habtewold
    6. Julia A. Cai
    7. Gauri Sachiko Saini
    8. Huong Nguyen
    9. Nikolai Windbichler
    10. George K. Christophides

    Reviewed by PREreview

    This article has 2 evaluationsAppears in 2 listsLatest version Latest activity
  7. RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

    This article has 26 authors:
    1. Teng-Feng Li
    2. Paul Rothhaar
    3. Arthur Lang
    4. Oliver Grünvogel
    5. Ombretta Colasanti
    6. Santa Mariela Olivera Ugarte
    7. Jannik Traut
    8. Antonio Piras
    9. Nelson Acosta-Rivero
    10. Vladimir Gonçalves Magalhães
    11. Emely Springer
    12. Andreas Betz
    13. Hao-En Huang
    14. Jeongbin Park
    15. Ruiyue Qiu
    16. Gnimah Eva Gnouamozi
    17. Ann-Kathrin Mehnert
    18. Viet Loan Dao Thi
    19. Stephan Urban
    20. Martina Muckenthaler
    21. Matthias Schlesner
    22. Dirk Wohlleber
    23. Marco Binder
    24. Ralf Bartenschlager
    25. Andreas Pichlmair
    26. Volker Lohmann

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers

    This article has 16 authors:
    1. SV Krasik
    2. EA Bryushkova
    3. GV Sharonov
    4. DS Myalik
    5. EV Shurganova
    6. DV Komarov
    7. IA Shagina
    8. PS Shpudeiko
    9. MA Turchaninova
    10. MT Vakhitova
    11. IV Samoylenko
    12. DT Marinov
    13. LV Demidov
    14. VE Zagainov
    15. DM Chudakov
    16. EO Serebrovskaya
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides useful insights into inter- and intra-site B cell receptor repertoire heterogeneity, noting that B cell clones from the tumour interact more with their draining lymph node than with the blood and that there is less mutation/expansion/activation of B cell clones in tumours. Unfortunately, the main claims are incomplete and only partially supported. The work could be of interest to an audience including medical biologists/immunologists and computational biologists across cancer specialities.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  9. Thymic self-recognition-mediated TCR signal strength modulates antigen-specific CD8+ T cell pathogenicity in non-obese diabetic mice

    This article has 5 authors:
    1. Chia-Lo Ho
    2. Li-Tzu Yeh
    3. Yu-Wen Liu
    4. Jia-Ling Dong
    5. Huey-Kang Sytwu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study explores T cell receptor activation during autoreactive T cell development and how the strength of T cell receptor engagement in naïve cells can predispose T cells to develop into effector/memory T cells. Solid evidence confirms published data that naïve T cells with higher CD5 expression were poised for activation and more pathogenic in the mouse model of autoimmune diabetes. However, the evidence regarding the regulation of differentiation of these cells during development is still incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Amphibian mast cells: barriers to chytrid fungus infections

    This article has 15 authors:
    1. Kelsey A Hauser
    2. Christina N Garvey
    3. Ryley S Crow
    4. Muhammad RH Hossainey
    5. Dustin T Howard
    6. Netra Ranganathan
    7. Lindsey K Gentry
    8. Amulya Yaparla
    9. Namarta Kalia
    10. Mira Zelle
    11. Elizabeth J Jones
    12. Anju N Duttargi
    13. Louise A Rollins-Smith
    14. Carly R Muletz-Wolz
    15. Leon Grayfer
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study reveals the role of skin-resident mast cells in amphibians in mediating antimicrobial responses. The data are compelling and highlight species-specific biology that can cross-inform human mast cell biology in a species that does not rely on IgE as a primary mechanism for antimicrobial skin responses.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity