Immunology

Macrophages redeploy functional cancer cell surface proteins following phagocytosis

1. Regan F. Volk
2. Sara W. Casebeer
3. Andrew C. Condon
4. Bahar Zirak
5. Nayelis Manon
6. Iryna Irkliyenko
7. Huajun Liao
8. Shao Tao
9. Tommaso Pollini
10. Vijay Ramani
11. Ajay V. Maker
12. Trevor Fidler
13. Hani Goodarzi
14. Balyn W. Zaro

Reviewed by PREreview

Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

1. Fatima Tleiss
2. Martina Montanari
3. Romane Milleville
4. Olivier Pierre
5. Julien Royet
6. Dani Osman
7. Armel Gallet
8. C. Léopold Kurz

• Curated by eLife

  eLife Assessment

  This article describes a novel mechanism allows Drosophila to combat enteric pathogens while also preserving the beneficial indigenous microbiota. The authors provide compelling evidence that oral infection of Drosophila larvae by pathogenic bacteria activate a valve that traps the intruders in the anterior midgut, allowing them to be killed by antimicrobial peptides. This is an important finding revealing a new mechanism of host defense in the gut of insects.

Reviewed by eLife

Nociceptor Neurons Control Pollution-Mediated Neutrophilic Asthma

1. Jo-Chiao Wang
2. Theo Crosson
3. Amin Reza Nikpoor
4. Surbhi Gupta
5. Moutih Rafei
6. Sebastien Talbot

• Curated by eLife

  eLife Assessment

  The study is a valuable addition to the field, showing how particulate matter may be acting via nociceptor neurons towards neutrophilic asthma exacerbations. The solid evidence for the role of a nociceptive pathway in model systems is relevant to human asthma in its current form but would be further strengthened by mechanistic insights. This would be particularly relevant to further translational research towards blocking the exacerbating effect of air pollution on asthma.

Reviewed by eLife

Heparan sulphate binding controls in vivo half-life of the HpARI protein family

1. Florent Colomb
2. Abhishek Jamwal
3. Adefunke Ogunkanbi
4. Tania Frangova
5. Alice R Savage
6. Sarah Kelly
7. Gavin J Wright
8. Matthew K Higgins
9. Henry J McSorley

• Curated by eLife

  eLife Assessment

  This important study uses in vitro and in vivo methods to identify HpARI proteins from H. polygyrus as modulators of the host immune system. The data from comprehensive approaches for investigating differential roles of HpARI proteins are convincing. This paper is relevant to those who investigate host-pathogen interactions at the systems and molecular levels.

Reviewed by eLife

Mast cells promote pathology and susceptibility in tuberculosis

1. Ananya Gupta
2. Vibha Taneja
3. Javier Rangel Moreno
4. Abhimanyu
5. Mushtaq Ahmed
6. Nilofer Naqvi
7. Kuldeep S Chauhan
8. Daniela Trejo-Ponce de León
9. Gustavo Ramírez-Martínez
10. Luis Jiménez-Alvarez
11. Cesar Luna-Rivero
12. Joaquin Zuniga
13. Deepak Kaushal
14. Shabaana A Khader

• Curated by eLife

  eLife Assessment

  In this useful study, the authors use published scRNA-seq data to highlight the importance of mast cells (MCs) in TB granulomas, reporting a comparative assessment of chymase- and tryptase-expressing MCs in the lungs of tuberculosis-infected individuals and non-human primates, with MC-deficient mice showing reduced lung bacterial burden and pathology during infection. Whilst the findings are helpful, the evidence to support conclusions is inconsistent across models and thus incomplete. Specifically, the data supporting a role for MCs in coordinating cytokine responses to modulate pathology, susceptibility to tuberculosis, and dissemination during infection are weak.

Reviewed by Arcadia Science, eLife

One N-glycan regulates natural killer cell antibody-dependent cell-mediated cytotoxicity and modulates Fc γ receptor IIIa / CD16a structure

1. Paul G Kremer
2. Elizabeth A Lampros
3. Allison M Blocker
4. Adam W Barb

• Curated by eLife

  eLife Assessment

  This study explores the mechanistic link between glycosylation at the N162 site of the Fc gamma receptor FcγRIIIa and the modulation of NK cell-mediated antibody-dependent cytotoxicity. Using innovative isotope labeling strategies and advanced NMR spectroscopy techniques, the authors provide compelling evidence of how glycan composition influences receptor stability and immune function. These findings offer fundamental insights that may contribute to the development of more effective therapeutic antibodies. The manuscript will be of significant interest to immunologists and researchers focused on therapeutic antibody design.

Reviewed by eLife

PRR adjuvants restrain high stability peptides presentation on APCs

1. Bin Li
2. Jin Zhang
3. Taojun He
4. Hanmei Yuan
5. Hui Wu
6. Peng Wang
7. Chao Wu

• Curated by eLife

  eLife Assessment

  This important study provides interesting insights into the mechanisms of action of adjuvants. It shows that adjuvants, MPLA and CpG especially, modulate the peptide repertoires presented on the surface of antigen presenting cells, and surprisingly, adjuvant favored the presentation of low-stability peptides rather than high-stability peptides by antigen presenting cells. As a result, the low stability peptide presented in adjuvant groups elicits T cell response effectively. Evidence in support of these conclusions is solid, and this paper would be of interest to vaccinologists and immunologists.

Reviewed by eLife

A host enzyme reduces non-alcoholic fatty liver disease by inactivating intestinal lipopolysaccharide

1. Zhiyan Wang
2. Nore Ojogun
3. Yiling Liu
4. Lu Gan
5. Zeling Xiao
6. Jintao Feng
7. Wei Jiang
8. Yeying Chen
9. Benkun Zou
10. Cheng-Yun Yu
11. Changshun Li
12. Asha Ashuo
13. Xiaobo Li
14. Mingsheng Fu
15. Jian Wu
16. Yiwei Chu
17. Robert Munford
18. Mingfang Lu

• Curated by eLife

  eLife Assessment

  This important study highlights the key role of the gut-liver axis mediated by LPS in causing hepatic steatosis. The authors provide solid evidence, in vivo, in vitro, and in silico, for the role of acyloxyacyl hydrolase in mediating this effect using KO mice subjected to MASD-inducing diets. The findings are significant for the liver research community and others interested in the gut-liver axis.

Reviewed by eLife

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

1. Toru Tanaka
2. Naoto Sasaki
3. Aga Krisnanda
4. Hilman Zulkifli Amin
5. Ken Ito
6. Sayo Horibe
7. Kazuhiko Matsuo
8. Ken-ichi Hirata
9. Takashi Nakayama
10. Yoshiyuki Rikitake

• Curated by eLife

  eLife Assessment

  This important study provides solid in-vivo evidence that CCR4 regulates the early inflammatory response during atherosclerotic plaque formation. The authors propose that altered T-cell response plays a role in this process, shedding light on mechanisms that may be of interest to medical biologists, biochemists, cell biologists, and immunologists. Further in vivo validation, mechanistic studies, and discussion of results in vitro suggested would be helpful to cement the significance and implications of these findings.

Reviewed by eLife

A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome

1. Yan Qian
2. Qiannv Liu
3. Weitao Li
4. Chunlei Wang
5. Chun Kong
6. Mengqian Li
7. Shuo Wang
8. Pengyan Xia

• Curated by eLife

  eLife Assessment

  This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and the generation of fragments that inhibit activity of the NLRP3 inflammasome. This work should be of interest to immunologists and microbiologists.

Reviewed by eLife