Immunology

  1. A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

    1. Jordan Z. Zhou
    2. Bihui Huang
    3. Bo Pei
    4. Guang Wen Sun
    5. Michael D. Pawlitz
    6. Wei Zhang
    7. Xinyang Li
    8. Kati C. Hokynar
    9. Fayi Yao
    10. Madusha L. W. Perera
    11. Shanqiao Wei
    12. Simin Zheng
    13. Lisa A. Polin
    14. Janet M. Poulik
    15. Annamari Ranki
    16. Kai Krohn
    17. Charlotte Cunningham-Rundles
    18. Naibo Yang
    19. Ashok S. Bhagwat
    20. Kefei Yu
    21. Pärt Peterson
    22. Kai Kisand
    23. Bao Q. Vuong
    24. Andrea Cerutti
    25. Kang Chen

    • Curated by eLife

      eLife Assessment

      AIRE has been well known to contribute to immune self-tolerance in the thymus by expressing auto-antigens; in this manuscript, the authors describe unexpected findings about the interaction of AIRE with AID in B cells, and its function in the immune system, thereby contributing to a fundamental understanding of the broader functions of AIRE. The strength of this manuscript is that, by employing biochemical and genetic experiments, the authors convincingly show interaction between AIRE and AID and subsequent AIRE's function in the GC responses. However, two weak points exist: first, the connection between AIRE, auto-anti IL17 Abs, and IL17-positive effector T cells, and second, like the thymus, expression of auto-antigens by AIRE in the GC B cells has not been tested.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. Contrasting roles for IKK regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive 𝛄δ T cells

    1. Farjana Islam
    2. Cayman Williams
    3. Thea Hogan
    4. Louise Webb
    5. Ines Boal-Carvalho
    6. Benedict Seddon

    • Curated by eLife

      eLife Assessment

      This study reports important findings regarding the role of the NF-kB signaling pathway in the development and long-term survival of gamma delta T cells. The authors report disparate roles of IKK-dependent NF-kB activation in the development and long-term survival of gamma delta T cell subsets. The approach and methodology employed is convincing. This work will be of great interest to immunologists interested in innate-like T cell biology and in T cell development.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  3. Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens

    1. Se-Jin Kim
    2. Jessie C Peterson
    3. Andrew J Olive
    4. Fikadu G Tafesse
    5. Corinna A Kulicke
    6. Elham Karamooz
    7. David M Lewinsohn

    • Curated by eLife

      eLife Assessment

      This useful study examines the contribution of synaptotagmin 1 and synaptotagmin 7 to metabolite antigen presentation to mucosal-associated invariant T (MAIT) cells; it begins to address a critical gap in our understanding of the antigen presentation mechanisms of these cells. Strengths of the study include the use of Mtb to study the dynamics of antigen presentation to MAIT cells instead of a synthetic antigen. The strength of the evidence to support the conclusion is solid.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  4. Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functions

    1. Yu Hong
    2. Xiaofang Si
    3. Wenjing Liu
    4. Xueying Mai
    5. Yu Zhang

    • Curated by eLife

      eLife Assessment

      The important study uses genome-wide CRISPR/Cas9 screenings to identify a novel target B4GALTZ1 that is implicated in modulating CD8+ T cell function in the context of anti-tumor immunity. The strength of evidence is solid but could benefit from more detail, particularly to verify the efficiency of knockout in their single gene KO lines and identification of N-glycosylation sites of TCR and CD8s. This work highlights the role of protein N-glycosylation, particularly B4GALT1 deficiency, in regulating CD8 function and anti-tumor immunity.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  5. Daytime variation in SARS-CoV-2 infection and cytokine production

    1. Aïssatou Bailo Diallo
    2. Laetitia Gay
    3. Benjamin Coiffard
    4. Marc Leone
    5. Soraya Mezouar
    6. Jean-Louis Mege

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

    4 evaluationsAppears in 2 listsLatest version Latest activity

  6. Pre-existing YFV-17D immunity mediates T cell cross-protection against DENV-2 infection

    1. Prince Baffour Tonto
    2. Sebastian Gallon
    3. Reem Alatrash
    4. Wei-Kung Wang
    5. Bobby Brooke Herrera

    Reviewed by Rapid Reviews Infectious Diseases, PREreview

    6 evaluationsAppears in 2 listsLatest version Latest activity

  7. High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

    1. Willianne Hoepel
    2. Hung-Jen Chen
    3. Chiara E. Geyer
    4. Sona Allahverdiyeva
    5. Xue D. Manz
    6. Steven W. de Taeye
    7. Jurjan Aman
    8. Lynn Mes
    9. Maurice Steenhuis
    10. Guillermo R. Griffith
    11. Peter I. Bonta
    12. Philip J.M. Brouwer
    13. Tom G. Caniels
    14. Karlijn van der Straten
    15. Korneliusz Golebski
    16. René E. Jonkers
    17. Mads D. Larsen
    18. Federica Linty
    19. Jan Nouta
    20. Cindy P.A.A. van Roomen
    21. Frank E.H.P. van Baarle
    22. Cornelis M. van Drunen
    23. Gertjan Wolbink
    24. Alexander P.J. Vlaar
    25. Godelieve J. de Bree
    26. Rogier W. Sanders
    27. Lisa Willemsen
    28. Annette E. Neele
    29. Diederik van de Beek
    30. Theo Rispens
    31. Manfred Wuhrer
    32. Harm Jan Bogaard
    33. Marit J. van Gils
    34. Gestur Vidarsson
    35. Menno de Winther
    36. Jeroen den Dunnen

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT, preLights

    6 evaluationsAppears in 3 listsLatest version Latest activity

  8. A conserved immune dysregulation is associated with infection severity, risk factors prior to infection, and treatment response

    1. Ananthakrishnan Ganesan
    2. Andrew R. Moore
    3. Hong Zheng
    4. Jiaying Toh
    5. Michael Freedman
    6. Andrew T. Magis
    7. James R. Heath
    8. Purvesh Khatri

    Reviewed by Rapid Reviews Infectious Diseases

    2 evaluationsAppears in 1 listLatest version Latest activity

  9. Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

    1. Suelen da Silva Gomes Dias
    2. Vinicius Cardoso Soares
    3. André C. Ferreira
    4. Carolina Q. Sacramento
    5. Natalia Fintelman-Rodrigues
    6. Jairo R. Temerozo
    7. Lívia Teixeira
    8. Ester Barreto
    9. Mayara Mattos
    10. Caroline S. de Freitas
    11. Isaclaudia G. Azevedo-Quintanilha
    12. Pedro Paulo A. Manso
    13. Eugenio D. Hottz
    14. Camila R. R. Pão
    15. Dumith C. Bou-Habib
    16. Fernando A. Bozza
    17. Thiago M. L. Souza
    18. Patrícia T. Bozza

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

    5 evaluationsAppears in 2 listsLatest version Latest activity

  10. Dual Role of Glycosylation in Resistance to CD4-binding Site Broadly Neutralizing Antibodies

    1. Teresa Murphy
    2. Meagan Kelly
    3. Kai S. Shimagaki
    4. Thomas DeStefanis
    5. Gabriel Galeotos
    6. Myungjin Lee
    7. Qing Wei
    8. Jan Novak
    9. Katharine J. Bar
    10. John P. Barton
    11. Rebecca M. Lynch

    Reviewed by Rapid Reviews Infectious Diseases

    5 evaluationsAppears in 1 listLatest version Latest activity
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