1. Xcr1 + type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

    This article has 17 authors:
    1. Tianhan Li
    2. Liaoxun Lu
    3. Juanjuan Qiu
    4. Xin Dong
    5. Le Yang
    6. Kexin He
    7. Yanrong Gu
    8. Binhui Zhou
    9. Tingting Jia
    10. Toby Lawrence
    11. Marie Malissen
    12. Guixue Wang
    13. Rong Huang
    14. Hui Wang
    15. Bernard Malissen
    16. Yinming Liang
    17. Lichen Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript by Li, Lu et al., presents important findings on the role of cDC1 in atherosclerosis and their influence on the adaptive immune system. Using Xcr1Cre-Gfp Rosa26LSL-DTA ApoE-/- mouse models, these data convincingly reveal an unexpected, non-redundant role of the XCL1-XCR1 axis in mediating cDC1 contributions to atherosclerosis.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

    This article has 11 authors:
    1. Wesley H Godfrey
    2. Judy J Lee
    3. Shruthi Shanmukha
    4. Kaho Cho
    5. Xiaojing Deng
    6. Chandra Shekar R Ambati
    7. Vasanta Putluri
    8. Abu Hena Mostafa Kamal
    9. Paul M Kim
    10. Nagireddy Putluri
    11. Michael D Kornberg
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper highlights an important physiological function of PGAM in the differentiation and suppressive activity of Treg cells by regulating serine synthesis. This role is proposed to intersect with glycolysis and one-carbon metabolism. The study's conclusion is supported by solid evidence from in-vitro cellular and in-vivo mouse models.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. Pediatric cerebrospinal fluid immune profiling distinguishes pediatric-onset multiple sclerosis from other pediatric-onset acute neurological disorders

    This article has 25 authors:
    1. Diego A. Espinoza
    2. Tobias Zrzavy
    3. Gautier Breville
    4. Simon Thebault
    5. Amaar Marefi
    6. Ina Mexhitaj
    7. Luana D. Yamashita
    8. Mengyuan Kan
    9. Micky Bacchus
    10. Jessica Legaspi
    11. Samantha Fernandez
    12. Anna Melamed
    13. Mallory Stubblebine
    14. Yeseul Kim
    15. Zachary Martinez
    16. Caroline Diorio
    17. Andreas Schulte-Mecklenbeck
    18. Heinz Wiendl
    19. Ayman Rezk
    20. Rui Li
    21. Sona Narula
    22. Amy T. Waldman
    23. Sarah E. Hopkins
    24. Brenda Banwell
    25. Amit Bar-Or

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

    This article has 11 authors:
    1. Liangliang Fu
    2. Chenghu Yin
    3. Qin Zhao
    4. Shuling Guo
    5. Wenjun Shao
    6. Ting Xia
    7. Quan Sun
    8. Liangwen Chen
    9. Jinghan Li
    10. Min Wang
    11. Haibin Xia
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study identifies a population of CD81-positive fibroblasts showing senescence signatures that can activate neutrophils through the C3/C3aR1 axis, hence contributing to the inflammatory response in periodontitis. Solid evidence, combining in vitro and in vivo analyses and mouse and human data, supports these findings. The revised manuscript has addressed many concerns significantly. The work would be of interest to researchers working in the senescence and oral medicine fields.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. Layilin Regulates Treg Motility and Suppressive Capacity in Skin

    This article has 18 authors:
    1. Victoire Gouirand
    2. Sean Clancy
    3. Courtney Macon
    4. Jose Valle
    5. Mariela Pauli
    6. Hong-An Troung
    7. Jarish Cohen
    8. Maxime Kinet
    9. Margaret M Lowe
    10. Samuel J Lord
    11. Kristen Skruber
    12. Hobart Harris
    13. Esther Kim
    14. Isaac Neuhaus
    15. Karin Reif
    16. Ali A Zarrin
    17. Dyche R Mullins
    18. Michael D Rosenblum
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study reports valuable findings on the role of Layilin in the motility and suppressive capacity of clonal expanded regulatory T cells (Tregs) in the skin. Although the strength of the study is utilizing conditional knock-out mice and human skin samples, the analysis of the molecular mechanism by which Layilin affects Treg function is incomplete. The study will be of interest to medical scientists working on skin immunology.

    Reviewed by eLife, Arcadia Science

    This article has 7 evaluationsAppears in 2 listsLatest version Latest activity
  6. Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention

    This article has 11 authors:
    1. Alisa Sukhina
    2. Clemence Queriault
    3. Saptarshi Roy
    4. Elise Hall
    5. Kelly Rome
    6. Muskaan Aggarwal
    7. Elizabeth Nunn
    8. Ashley Weiss
    9. Janet Nguyen
    10. F Chris Bennett
    11. Will Bailis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work advances our understanding of the impact of malnutrition on hematopoiesis and subsequently infection susceptibility. Support for the overall claims is convincing in some respects and incomplete in terms of identifying mechanism as highlighted by reviewers. This work will be of general interest to those in the fields of hematopoiesis, malnutrition, and dietary influence on immunity.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  7. Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin

    This article has 17 authors:
    1. Eric S Weiss
    2. Toshiro Hirai
    3. Haiyue Li
    4. Andrew Liu
    5. Shannon Baker
    6. Ian Magill
    7. Jacob Gillis
    8. Youran R Zhang
    9. Torben Ramcke
    10. Kazuo Kurihara
    11. The ImmGen Consortium OpenSource T cell Project
    12. David Masopust
    13. Niroshana Anandasabapathy
    14. Harinder Singh
    15. David Zemmour
    16. Laura K Mackay
    17. Daniel H Kaplan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Weiss et al. provide important new insights and convincing evidence to further our mechanistic understanding of how antigen presentation shapes skin persistence of CD8+ TRM. Using a mouse model for inducible genetic ablation of transforming growth factor beta receptor 3 (TGFBR3) in CD8+ T cells, they demonstrate TGFBR3's role in regulating CD8+ TRM persistence in skin. Furthermore, they show that the strength of T cell receptor (TCR) engagement upon initial CD8+ TRM skin seeding has a positive influence on subsequent TRM expansion following a secondary antigen-reencounter. Together, these mechanisms add to our understanding of how the skin CD8+ T cell repertoire is dynamically responsive to topical antigen.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. HIV-specific CD8+ T-cell responses soon after treatment initiation during acute HIV infection are associated with viral reservoir decline

    This article has 19 authors:
    1. Pien M van Paassen
    2. Alexander O Pasternak
    3. Karel A van Dort
    4. Ad C van Nuenen
    5. Irma Maurer
    6. Brigitte Boeser-Nunnink
    7. Ninée VEJ Buchholtz
    8. Tokameh Mahmoudi
    9. Cynthia Lungu
    10. Reinout van Crevel
    11. Casper Rokx
    12. Jori Symons
    13. Monique Nijhuis
    14. Annelou van der Veen
    15. Liffert Vogt
    16. Michelle J Klouwens
    17. Jan M Prins
    18. Neeltje A Kootstra
    19. Godelieve J de Bree
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable paper used a longitudinal cohort of individuals initiating ART to suggest that CD8+ T cells may contribute to the clearance of intact HIV DNA during long-term antiretroviral therapy (ART) for HIV, which is relevant to our understanding of the mechanisms driving reservoir persistence in people living with HIV. The reviewers concluded that the evidence presented is incomplete to fully support these claims, as the cohort sampling is relatively infrequent, and the association direction could be bi-directional or due to other confounding variables.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Coenzyme A governs proinflammatory macrophage metabolism

    This article has 13 authors:
    1. Greg. A. Timblin
    2. Kevin. M. Tharp
    3. Johanna ten Hoeve
    4. Daniel S. Kantner
    5. Ilayda Baydemir
    6. Eric A. Noel
    7. Chandra Khantwal
    8. Pankaj K. Singh
    9. Joshua N. Farahzad
    10. Jorge Domínguez-Andrés
    11. Russell E. Vance
    12. Nathaniel W. Snyder
    13. Valerie M. Weaver
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and assessments of transcription and acetylation. Together, these provide a compelling series of findings that show exogenous CoA is taken up by macrophages, and this facilitates histone acetylation and transcription associated with activation and antimicrobial activity.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Susceptibility of Kit-mutant mice to sepsis caused by enteral dysbiosis, not mast cell deficiency

    This article has 4 authors:
    1. Thorsten B Feyerabend
    2. Fabienne Schochter
    3. Alpaslan Tasdogan
    4. Hans-Reimer Rodewald
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a useful finding showing that the high susceptibility to sepsis of Kit-mutant mice is due to dysbiosis. However, the data provided is incomplete and would benefit from more rigorous approaches. With the mechanism part strengthened, this paper would be of interest to researchers on mast cell biology and mucosal immunology.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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