Genetics

Identifying the genetic basis and molecular mechanisms underlying phenotypic correlation between complex human traits using a gene-based approach

1. Jialiang Gu
2. Chris Fuller
3. Peter Carbonetto
4. Xin He
5. Jiashun Zheng
6. Hao Li

• Curated by eLife

  eLife Assessment

  To evaluate phenotypic correlations between complex traits, this study aimed to measure the genetic overlap of traits by evaluating GWAS signals assisted by eQTL signals. They suggested an improved version of the previous Sherlock to integrate SNP-level signals into gene-level signals. Then they compared 59 human traits to identify known and novel genetic distance relationships. This work is valuable to the field, but still needs substantial improvement because many parts of the paper are incomplete.

Reviewed by eLife

Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

1. Wei-Ping Li
2. Jia-Ying Su
3. Yu-Chi Chang
4. Hung-Lun Chiang
5. Yun-Lin Wang
6. Ang-Chu Huang
7. Yu-Tung Hsieh
8. Yi-Hsuan Chiang
9. Yen-Ling Ko
10. Bing-Jen Chiang
11. Cheng-Han Yang
12. Yen-Tsung Huang
13. Chien-Ling Lin

• Curated by eLife

  eLife Assessment

  The effort is timely and the paper carries valuable insights into the function of UTR mutations. There are still significant concerns about both the quality of the screen data, and its ability to detect significant changes in translation and their direction. Therefore, the ability of the screen to support the extensive downstream statistical analysis is limited and leaves the paper incomplete.

Reviewed by eLife

Inflammation-Induced Alternative Splicing in Human Endothelial Cells Reveals Genetic Mechanisms of Cardiovascular Disease Risk

1. Anna K. Golebiewski
2. Lindsey K. Stolze
3. Valentina D. Vazquez
4. Alhan Mehrabi Yazdi
5. Cecilia M. Careaga
6. Casey E. Romanoski

Reviewed by Arcadia Science

Life-history trade-offs explain local adaptation in Arabidopsis thaliana

1. Benjamin Brachi
2. Danièle L Filiault
3. Rahul Pisupati
4. Tal Dahan-Meir
5. Anna Igolkina
6. Alison Anastasio
7. Mathew S Box
8. Susan Duncan
9. Talia L Karasov
10. Envel Kerdaffrec
11. Laura Merwin
12. Timothy C Morton
13. Viktoria Nizhynska
14. Polina Yu Novikova
15. Fernando Rabanal
16. Takashi Tsuchimatsu
17. Torbjörn Säll
18. Caroline Dean
19. Svante Holm
20. Joy Bergelson
21. Magnus Nordborg

• Curated by eLife

  eLife Assessment

  This manuscript reports a large series of experiments to investigate specific aspects of plant adaptation, leveraging genetic and genomic resources of Arabidopsis thaliana. The study provides convincing evidence for local adaptation in this highly selfing plant. This is an important dataset contributing to the developing understanding of non-linear selection in plants and beyond.

Reviewed by eLife

Borzoi-informed fine mapping improves causal variant prioritization in complex trait GWAS

1. Divyanshi Srivastava
2. Anya Korsakova
3. Qingbo Wang
4. Luong Ruiz
5. Han Yuan
6. David R Kelley

Reviewed by Arcadia Science

The strength of weird ties: positive genetic interactions have greater scientific impact but are under-represented in the literature

1. Mengyi Sun
2. David M. McCandlish

Reviewed by Arcadia Science