Genetics

Assessing target genes for homing suppression gene drive

1. Xuejiao Xu
2. Jialing Fang
3. Jingheng Chen
4. Jie Yang
5. Xiaozhen Yang
6. Shibo Hou
7. Weitang Sun
8. Jackson Champer

Reviewed by Review Commons

Genetic Modifiers Influencing the Acute and Long-Term Responses to Traumatic Brain Injury in Drosophila

1. Brandon Molina
2. Jesse Jacob Rojas
3. Nadja El-Mecharrafie
4. Eric P Ratliff
5. Marta Lipinski
6. Kim Diane Finley

Reviewed by PREreview

Identifying the genetic basis and molecular mechanisms underlying phenotypic correlation between complex human traits using a gene-based approach

1. Jialiang Gu
2. Chris Fuller
3. Peter Carbonetto
4. Xin He
5. Jiashun Zheng
6. Hao Li

• Curated by eLife

  eLife Assessment

  To evaluate phenotypic correlations between complex traits, this study aimed to measure the genetic overlap of traits by evaluating GWAS signals assisted by eQTL signals. They suggested an improved version of the previous Sherlock to integrate SNP-level signals into gene-level signals. Then they compared 59 human traits to identify known and novel genetic distance relationships. This work is valuable to the field, but still needs substantial improvement because many parts of the paper are incomplete.

Reviewed by eLife

Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

1. Wei-Ping Li
2. Jia-Ying Su
3. Yu-Chi Chang
4. Hung-Lun Chiang
5. Yun-Lin Wang
6. Ang-Chu Huang
7. Yu-Tung Hsieh
8. Yi-Hsuan Chiang
9. Yen-Ling Ko
10. Bing-Jen Chiang
11. Cheng-Han Yang
12. Yen-Tsung Huang
13. Chien-Ling Lin

• Curated by eLife

  eLife Assessment

  The effort is timely and the paper carries valuable insights into the function of UTR mutations. There are still significant concerns about both the quality of the screen data, and its ability to detect significant changes in translation and their direction. Therefore, the ability of the screen to support the extensive downstream statistical analysis is limited and leaves the paper incomplete.

Reviewed by eLife

Inflammation-Induced Alternative Splicing in Human Endothelial Cells Reveals Genetic Mechanisms of Cardiovascular Disease Risk

1. Anna K. Golebiewski
2. Lindsey K. Stolze
3. Valentina D. Vazquez
4. Alhan Mehrabi Yazdi
5. Cecilia M. Careaga
6. Casey E. Romanoski

Reviewed by Arcadia Science

Borzoi-informed fine mapping improves causal variant prioritization in complex trait GWAS

1. Divyanshi Srivastava
2. Anya Korsakova
3. Qingbo Wang
4. Luong Ruiz
5. Han Yuan
6. David R Kelley

Reviewed by Arcadia Science