Genetics

Is competition for cellular resources a driver of complex trait heritability?

1. Olivier Naret
2. Yuval Simons
3. Jacques Fellay
4. Jonathan K Pritchard

• Curated by eLife

  eLife assessment

  This solid study addresses the unresolved question of why many thousands of small-effect loci contribute more to the heritability of a trait than the large-effect lead variants. The authors explore resource competition within the transcriptional machinery as one possible explanation with a simple theoretical model, concluding that the effects of resource competition would be too small to explain the heritability effects. The topic and approximation of the problem are important and offer an intuitive way to think about polygenic variation, but there are concerns on the derivation of the equations with respect to dropping vs. including certain terms that deal inherently with small numbers.

Reviewed by eLife

Efficient genome editing using modified Cas9 proteins in zebrafish

1. Laura Dorner
2. Benedikt Stratmann
3. Laura Bader
4. Marco Podobnik
5. Uwe Irion

Reviewed by Review Commons

Simultaneous Inference of Past Demography and Selection from the Ancestral Recombination Graph under the Beta Coalescent

1. Kevin Korfmann
2. Thibaut Paul Patrick Sellinger
3. Fabian Freund
4. Matteo Fumagalli
5. Aurélien Tellier

Reviewed by Peer Community in Evolutionary Biology

Fas2EB112 : a tale of two chromosomes

1. Tara M Finegan
2. Christian Cammarota
3. Oscar Mendoza Andrade
4. Audrey M Garoutte
5. Dan T Bergstralh

Reviewed by Review Commons

Assessing the potential of germplasm collections for the management of genetic diversity: the case of the French National Cryobank

1. Alicia Jacques
2. Delphine Duclos
3. Coralie Danchin-Burge
4. Marie-José Mercat
5. Michèle Tixier-Boichard
6. Gwendal Restoux

Reviewed by Peer Community in Animal Science