Genetics

All three MutL complexes are required for repeat expansion in a human stem cell model of CAG-repeat expansion mediated glutaminase deficiency

1. Bruce Hayward
2. Daman Kumari
3. Saikat Santra
4. Clara D. M. van Karnebeek
5. André B. P. van Kuilenburg
6. Karen Usdin

Reviewed by Arcadia Science

The ZMYND8 chromatin factor protects cardiomyocyte identity and function in the mouse heart

1. Andrew Kekūpaʻa Knutson
2. Abigail Avelar
3. Ralph V. Shohet

Reviewed by Review Commons

Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins

1. Elena Martínez-Balsalobre
2. Monique Anchelin
3. David Hernández-Silva
4. Maria C Mione
5. Victoriano Mulero
6. Francisca Alcaraz-Pérez
7. Jesús García-Castillo
8. María L Cayuela

Reviewed by Review Commons

The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility in Drosophila melanogaster

1. Nora C Brown
2. Benjamin Gordon
3. Caitlin E McDonough-Goldstein
4. Snigdha Misra
5. Geoffrey D Findlay
6. Andrew G Clark
7. Mariana Federica Wolfner

• Curated by eLife

  eLife assessment

  This important study describes an atypical role of the odorant binding protein Obp56g in mating plug formation in Drosophila melanogaster suggesting that Obps may play roles in reproduction in addition to their originally described roles in olfaction. Mutant males lacking Obp56g fail to induce the formation of a mating plug in the female reproductive tract-leading to ejaculate loss and reduced sperm storage. The evidence supporting the claims of the authors is solid and compelling. The work will be of interest to biologists studying Obps and seminal fluid protein function and their evolution.

Reviewed by eLife