Epidemiology

Identifying metabolic features of colorectal cancer liability using Mendelian randomization

1. Caroline Bull
2. Emma Hazelwood
3. Joshua A Bell
4. Vanessa Tan
5. Andrei-Emil Constantinescu
6. Carolina Borges
7. Danny Legge
8. Kimberley Burrows
9. Jeroen R Huyghe
10. Hermann Brenner
11. Sergi Castellvi-Bel
12. Andrew T Chan
13. Sun-Seog Kweon
14. Loic Le Marchand
15. Li Li
16. Iona Cheng
17. Rish K Pai
18. Jane C Figueiredo
19. Neil Murphy
20. Marc J Gunter
21. Nicholas J Timpson
22. Emma E Vincent

• Curated by eLife

  eLife assessment

  The manuscript by Bull et al provides valuable information on the relationship between metabolic features, in particular different lipoproteins and fatty acids, and colorectal cancer. They use solid methods and combine different data sources to analyze forward and reverse Mendelian Randomizations that support their claims.

Reviewed by eLife

Changes in stillbirths and child and youth mortality in 2020 and 2021 during the COVID-19 pandemic

1. Enrique Acosta
2. Lucia Hug
3. Helena Cruz-Castanheira
4. David Sharrow
5. José Henrique Monteiro da Silva
6. Danzhen You

Reviewed by PREreview

The impact of the UK COVID-19 lockdown on the screening, diagnostics and incidence of breast, colorectal, lung and prostate cancer in the UK: a population-based cohort study

1. Nicola L. Barclay
2. Marta Pineda Moncusí
3. Annika M. Jödicke
4. Daniel Prieto-Alhambra
5. Berta Raventós
6. Danielle Newby
7. Antonella Delmestri
8. Wai Yi Man
9. Xihang Chen
10. Marti Català

Reviewed by PREreview

Effect of an enhanced public health contact tracing intervention on the secondary transmission of SARS-CoV-2 in educational settings: The four-way decomposition analysis

1. Olivera Djuric
2. Elisabetta Larosa
3. Mariateresa Cassinadri
4. Silvia Cilloni
5. Eufemia Bisaccia
6. Davide Pepe
7. Laura Bonvicini
8. Massimo Vicentini
9. Francesco Venturelli
10. Paolo Giorgi Rossi
11. Patrizio Pezzotti
12. Alberto Mateo Urdiales
13. Emanuela Bedeschi
14. The Reggio Emilia Covid-19 Working Group

• Curated by eLife

  eLife assessment

  This study provides a potentially useful assessment of the effect of testing contacts of cases in school classes when identified, rather than at the end of quarantine, on both the number of secondary infections and other outcomes including tracing delay and identification of the possible source of infection. The authors find that the intervention likely led to a decrease in tracing delay and an increase in the number of possible sources of infection, though were unable to determine whether secondary transmission decreased, due in part to unmeasured confounding. While the surveillance system described provides a solid dataset appropriate for this analysis, the description of methods, study outcomes, and consideration of potential confounding factors is incomplete.

Reviewed by eLife

Risk of second primary cancers after a diagnosis of first primary cancer: A pan-cancer analysis and Mendelian randomization study

1. Xiaohao Ruan
2. Da Huang
3. Yongle Zhan
4. Jingyi Huang
5. Jinlun Huang
6. Ada Tsui-Lin Ng
7. James Hok-Leung Tsu
8. Rong Na

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the associations and causal relationship between second primary cancers and the initial diagnosis of a primary cancer via using a large database. The evidence supporting the claims of the authors is solid. The work will be of interest to cancer clinicians.

Reviewed by eLife

Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP

1. Agnieszka Lemanska
2. Colm Andrews
3. Louis Fisher
4. Seb Bacon
5. Adam E Frampton
6. Amir Mehrkar
7. Peter Inglesby
8. Simon Davy
9. Keith Roberts
10. Praveetha Patalay
11. Ben Goldacre
12. Brian MacKenna
13. The OpenSAFELY Collaborative
14. Alex J Walker

• Curated by eLife

  eLife assessment

  This study provides useful information on the impact of the pandemic on the quantity of healthcare delivered to patients with pancreatic cancer in England. The authors showed that there was no difference in the number of diagnoses of pancreatic cancer during the pandemic compared to the preceding 5-year period, but a reduction in surgical resections by nearly 25%. They reported no difference in deaths between the two periods. They show no differences in rates of diagnosis, but the clinical relevance is incomplete as they have not compared survival from cancer between those time periods.

Reviewed by eLife

Epidemiological characteristics of COVID-19 patients in Samarinda, East Kalimantan, Indonesia

1. Swandari Paramita
2. Ronny Isnuwardana
3. Anton Rahmadi
4. Osa Rafshodia
5. Ismid Kusasih

Reviewed by ScreenIT

Pre-diagnostic circulating concentrations of insulin-like growth factor-1 and risk of COVID-19 mortality: results from UK Biobank

1. Xikang Fan
2. Cheng Yin
3. Jiayu Wang
4. Mingjia Yang
5. Hongxia Ma
6. Guangfu Jin
7. Mingyang Song
8. Zhibin Hu
9. Hongbing Shen
10. Dong Hang

Reviewed by ScreenIT

What effect might border screening have on preventing importation of COVID-19 compared with other infections? A modelling study

1. Declan Bays
2. Emma Bennett
3. Thomas Finnie

Reviewed by ScreenIT

Wastewater SARS-CoV-2 RNA Concentration and Loading Variability from Grab and 24-Hour Composite Samples

1. Kyle Curtis
2. David Keeling
3. Kathleen Yetka
4. Allison Larson
5. Raul Gonzalez

Reviewed by ScreenIT