Epidemiology

  1. Inferring variant-specific effective reproduction numbers from combined case and sequencing data

    1. Marlin D Figgins
    2. Trevor Bedford

    • Curated by eLife

      eLife Assessment

      This study provides new important insights concerning pathogen variant-specific reproduction parameters from molecular sequencing and case finding. The methods for inferring which variants will likely emerge in subsequent epidemic cycles are solid. This article is of broad interest to infectious disease epidemiology researchers and mathematical modellers of the COVID-19 pandemic.

    Reviewed by eLife, ScreenIT

    4 evaluationsAppears in 2 listsLatest version Latest activity

  2. Heterogenous associations of polygenic indices of 35 traits with mortality

    1. Hannu Lahtinen
    2. Jaakko Kaprio
    3. Andrea Ganna
    4. Kaarina Korhonen
    5. Stefano Lombardi
    6. Karri Silventoinen
    7. Pekka Martikainen

    • Curated by eLife

      eLife Assessment

      This valuable study reports convincing evidence about associations between 35 polygenic indices (PGIs) for social, behavioral, and psychological traits, along with some non-fatal health conditions (e.g., BMI) and all-cause mortality in data from Finnish population-based surveys and a twin cohort linked with administrative registers. PGIs for education, depression, alcohol use, smoking, BMI, and self-rated health showed the strongest associations with all-cause mortality, on the order of ~10% increment in risk per PGI standard deviation. Effect sizes from twin-difference analyses tended to be slightly larger than the effect sizes from population cohorts, opposite the pattern generally observed when testing PGI associations with their target phenotypes and supporting robustness of findings to confounding by population stratification.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  3. Forecasting the spatial spread of an Ebola epidemic in real time: Comparing predictions of mathematical models and experts

    1. James D Munday
    2. Alicia Rosello
    3. W John Edmunds
    4. Sebastian Funk

    • Curated by eLife

      eLife Assessment

      This manuscript provides valuable evidence comparing the performance of mathematical models and opinions from experts engaged in outbreak response in forecasting the spatial spread of an Ebola epidemic. The evidence supporting the conclusions is convincing. It will be of interest to disease modellers, infectious disease epidemiologists, policy-makers, and those who need to inform policy-makers during an outbreak.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  4. Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns

    1. Arnau Pujol
    2. Arlindo Chidimatembue
    3. Clemente da Silva
    4. Simone Boene
    5. Henriques Mbeve
    6. Pau Cisteró
    7. Carla García-Fernández
    8. Arnau Vañó-Boira
    9. Dário Tembisse
    10. José Inácio
    11. Glória Matambisso
    12. Fabião Luis
    13. Nelo Ndimande
    14. Humberto Munguambe
    15. Lidia Nhamussua
    16. Wilson Simone
    17. Andrés Aranda-Díaz
    18. Manuel García-Ulloa
    19. Neide Canana
    20. Maria Tusell
    21. Júlia Montaña
    22. Laura Fuente-Soro
    23. Khalid Ussene Bapu
    24. Maxwell Murphy
    25. Bernardete Rafael
    26. Eduard Rovira-Vallbona
    27. Caterina Guinovart
    28. Bryan Greenhouse
    29. Sonia Maria Enosse
    30. Francisco Saúte
    31. Pedro Aide
    32. Baltazar Candrinho
    33. Alfredo Mayor

    • Curated by eLife

      eLife Assessment

      This study introduces a useful method to estimate the probability that a malaria case is imported and to identify the geographic origin of parasites by using a Bayesian approach that integrates epidemiological, travel, and genetic data. The authors provide convincing evidence that the approach can reliably identify the main sources of malaria imports. This work will be of great interest to the area of genomic epidemiology and public health strategies aiming to eliminate malaria.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  5. Dynamic HIV risk differentiation among youth: Validation of a tool for prioritization of prevention in East Zimbabwe

    1. Louisa R Moorhouse
    2. Simon Gregson
    3. Jeffrey W Imai-Eaton
    4. Justin Mayini
    5. Tawanda Dadirai
    6. Phyllis Magoge-Mandizvidza
    7. Rufurwokuda Maswera
    8. Simbarashe Mabaya
    9. Rachel Baggaley
    10. Daniel Low-Beer
    11. Constance Nyamukapa
    12. Shona Dalal

    Reviewed by Rapid Reviews Infectious Diseases, PREreview

    4 evaluationsAppears in 2 listsLatest version Latest activity

  6. Shining light on the dark matter of pertussis: evidence for an asymptomatic carriage state from a longitudinal cohort of mother/infant dyads

    1. Christian E Gunning
    2. Christopher J Gill
    3. Pejman Rohani

    • Curated by eLife

      eLife Assessment

      This important study provides evidence for asymptomatic Bordetella pertussis carriage among mothers in a longitudinal cohort in Zambia, significantly advancing understanding of transmission dynamics. The evidence presented is convincing, with strengths including routine sampling irrespective of symptoms and rigorous qPCR methodology, although confirmatory diagnostics would further strengthen the claims. Overall, the study represents an influential contribution to the field of infectious disease epidemiology.

    Reviewed by Rapid Reviews Infectious Diseases, eLife

    6 evaluationsAppears in 2 listsLatest version Latest activity

  7. West Nile Virus ( Orthoflavivirus nilense ) RNA concentrations in wastewater solids at five wastewater treatment plants in the United States

    1. Alessandro Zulli
    2. Dorothea Duong
    3. Bridgette Shelden
    4. Amanda Bidwell
    5. Marlene K. Wolfe
    6. Bradley White
    7. Alexandria B. Boehm

    Reviewed by Rapid Reviews Infectious Diseases

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. How floods may affect the spatial spread of respiratory pathogens: the case of Emilia-Romagna, Italy in May 2023

    1. Claudio Ascione
    2. Eugenio Valdano

    Reviewed by Rapid Reviews Infectious Diseases

    2 evaluationsAppears in 1 listLatest version Latest activity

  9. A sex-specific Mendelian randomization-phenome-wide association study of body mass index

    1. Zhu Liduzi Jiesisibieke
    2. Io Ieong Chan
    3. Jack Chun Man Ng
    4. C Mary Schooling

    • Curated by eLife

      eLife Assessment

      The study presents valuable findings on Mendelian randomization-phenome-wide association, with BMI associated with health outcomes, and there is a focus on sex differences. The phenotype and genotype data are convincing. The work will be of interest to researchers and clinicians in epidemiology, public health and medicine.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  10. Investigation of an ongoing outbreak of ceftriaxone-resistant Salmonella enterica serovar Typhi in Bangladesh

    1. Yogesh Hooda
    2. Arif Mohammad Tanmoy
    3. Sudipta Deb Nath
    4. Anannya Barman Jui
    5. Al Amin
    6. Hafizur Rahman
    7. Neoyman Nasir Shorkar
    8. Naito Kanon
    9. Md Asadur Rahman
    10. Denise O Garrett
    11. Mohammad Shahidul Islam
    12. ASM Nawshad Uddin Ahmed
    13. Samir K Saha
    14. Senjuti Saha

    Reviewed by Rapid Reviews Infectious Diseases

    4 evaluationsAppears in 1 listLatest version Latest activity
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