Epidemiology

Antimicrobial resistance prevalence in bloodstream infection in 29 European countries by age and sex: An observational study

1. Naomi R. Waterlow
2. Ben S. Cooper
3. Julie V. Robotham
4. Gwenan Mary Knight

Reviewed by Rapid Reviews Infectious Diseases

Monitoring the Risk of Type-2 Circulating Vaccine-Derived Poliovirus Emergence During Roll-Out of Type-2 Novel Oral Polio Vaccine

1. Corey M. Peak
2. Hil Lyons
3. Arend Voorman
4. Elizabeth J. Gray
5. Laura V. Cooper
6. Isobel M. Blake
7. Kaija M. Hawes
8. Ananda S. Bandyopadhyay

Reviewed by Rapid Reviews Infectious Diseases

Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar

1. Hiam Chemaitelly
2. Houssein H Ayoub
3. Peter Coyle
4. Patrick Tang
5. Mohammad R Hasan
6. Hadi M Yassine
7. Asmaa A Al Thani
8. Zaina Al-Kanaani
9. Einas Al-Kuwari
10. Andrew Jeremijenko
11. Anvar Hassan Kaleeckal
12. Ali Nizar Latif
13. Riyazuddin Mohammad Shaik
14. Hanan F Abdul-Rahim
15. Gheyath K Nasrallah
16. Mohamed Ghaith Al-Kuwari
17. Hamad Eid Al-Romaihi
18. Mohamed H Al-Thani
19. Abdullatif Al-Khal
20. Roberto Bertollini
21. Adeel A Butt
22. Laith J Abu-Raddad

Reviewed by Rapid Reviews Infectious Diseases

Genomic epidemiology uncovers the timing and origin of the emergence of mpox in humans

1. Edyth Parker
2. Ifeanyi F. Omah
3. Patrick Varilly
4. Andrew Magee
5. Akeemat Opeyemi Ayinla
6. Ayotunde E. Sijuwola
7. Muhammad I. Ahmed
8. Oludayo O. Ope-ewe
9. Olusola Akinola Ogunsanya
10. Alhaji Olono
11. Philomena Eromon
12. Christopher H Tomkins-Tinch
13. James Richard Otieno
14. Olusola Akanbi
15. Abiodun Egwuenu
16. Odianosen Ehiakhamen
17. Chimaobi Chukwu
18. Kabiru Suleiman
19. Afolabi Akinpelu
20. Adama Ahmad
21. Khadijah Isa Imam
22. Richard Ojedele
23. Victor Oripenaye
24. Kenneth Ikeata
25. Sophiyah Adelakun
26. Babatunde Olajumoke
27. Delia Doreen Djuicy
28. Loique Landry Messanga Essengue
29. Moïse Henri Moumbeket Yifomnjou
30. Mark Zeller
31. Karthik Gangavarapu
32. Áine O’Toole
33. Daniel J Park
34. Gerald Mboowa
35. Sofonias Kifle Tessema
36. Yenew Kebede Tebeje
37. Onikepe Folarin
38. Anise Happi
39. Philippe Lemey
40. Marc A Suchard
41. Kristian G. Andersen
42. Pardis Sabeti
43. Andrew Rambaut
44. Richard Njoum
45. Chikwe Ihekweazu
46. Idriss Jide
47. Ifedayo Adetifa
48. Christian T Happi

Reviewed by Rapid Reviews Infectious Diseases

Antibiotic-resistance plasmid amplified among MRSA cases in an urban jail and its connected communities

1. Stephanie N. Thiede
2. Hannah Steinberg
3. Emily Benedict
4. Sarah Sansom
5. Alla Aroutcheva
6. Kyle J. Gontjes
7. Katherine Winner
8. Sonya Royzenblat
9. Ali Pirani
10. Robert A Weinstein
11. Chad Zawitz
12. Nicholas M. Moore
13. Kyle J. Popovich
14. Evan S. Snitkin

Reviewed by PREreview

Spatiotemporal relationships between extreme weather events and arbovirus transmission across Brazil

1. Victoria M Cox
2. Felipe Campos de Melo Iani
3. Wes Hinsley
4. Pedro S Peixoto
5. Flavio Codeço Coelho
6. Carlos Augusto Prete
7. Megan O’Driscoll
8. Neil Ferguson
9. Samir Bhatt
10. Nuno R Faria
11. Ilaria Dorigatti

• Curated by eLife

  eLife Assessment

  This study presents valuable findings from a spatiotemporal analysis of arbovirus case notification data from 2013 to 2020 in Brazil, reporting associations between covariates representing potential drivers of arbovirus transmission and recorded incidence. The work is methodologically solid, though it is unclear how much explanatory power inclusion of the covariates adds. The findings will be of interest to researchers working on the epidemiology of arboviruses.

Reviewed by eLife

A natural experiment in Kenya reveals durable immunosuppressive effects of early childhood malaria: a longitudinal cohort study

1. Mercy S Safari
2. Timothy O Makori
3. Elijah T Gicheru
4. Maureen W Mburu
5. Omar Nyawa
6. Faiz Shee
7. James Nyagwange
8. Eunice W Kagucia
9. Francis Ndungu
10. Timothy Chege
11. James O Tuju
12. Charles J Sande

• Curated by eLife

  eLife Assessment

  This important study sought to investigate the role that early childhood malaria exposure plays in the development of antibody responses to unrelated pathogens and vaccine-derived antigens in Kenyan children. In this natural experiment, the authors compare antibody levels among children who have been exposed to different levels of malaria transmission by using protein microarray technology. Although the findings are of importance, the evidence remains incomplete, and the analysis would benefit from a more in-depth evaluation of potential confounders. With the appropriate analysis, the findings will be of great interest for global health, immunology, and vaccine development.

Reviewed by eLife

Refining uncertainty about the TAK-003 dengue vaccine with a multi-level model of clinical efficacy trial data

1. Manar Alkuzweny
2. Guido España
3. T Alex Perkins

• Curated by eLife

  eLife Assessment

  This paper presents important new findings about the impact of the TAK-003 vaccine against dengue based on a convincing reanalysis of trial data. The results corroborate those of the original trial analyses, but with reduced uncertainty about the estimates of the impact of the vaccine. The findings will be of interest to clinicians, infectious disease epidemiologists, trial statisticians and policymakers seeking to understand the vaccine's efficacy profile and associated uncertainties.

Reviewed by eLife

Using step selection functions to analyse human mobility using telemetry data in infectious disease epidemiology: a case study of leptospirosis

1. Pablo Ruiz Cuenca
2. Fabio Neves Souza
3. Roberta Coutinho do Nascimento
4. Ariane Goncalves da Silva
5. Max T Eyre
6. Juliet O Santana
7. Daiana Santos de Oliveira
8. Emile Victoria Ribeiro de Souza
9. Fabiana Almerinda G Palma
10. Diogo César de Carvalho Santiago
11. Priscyla dos Santos Ribeiro
12. Priscilla Elizabeth Ferreira dos Santos
13. Hussein Khalil
14. Jonathan M Read
15. Cleber Cremonese
16. Federico Costa
17. Emanuele Giorgi

• Curated by eLife

  eLife Assessment

  This study makes a novel and valuable contribution by adapting step selection functions, traditionally used in animal ecology, to explore human movement and environmental risk exposure in urban slums, offering a promising framework for spatial epidemiology, particularly regarding leptospirosis. The integration of GPS telemetry with environmental data and the stratification by gender and serostatus are notable strengths that enhance the study's relevance for public health applications. The strength of evidence is compelling.

Reviewed by eLife

Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study

1. Fernanda Morales Berstein
2. Jasmine Khouja
3. Mark Gormley
4. Elmira Ebrahimi
5. Shama Virani
6. James D McKay
7. Paul Brennan
8. Tom G Richardson
9. Caroline L Relton
10. George Davey Smith
11. M Carolina Borges
12. Tom Dudding
13. Rebecca C Richmond

• Curated by eLife

  eLife Assessment

  This important study reports that higher genetically predicted BMI is associated with a modestly increased risk of head and neck cancer. The convincing evidence is supported by rigorous Mendelian Randomization approaches, using multiple genetic instruments and models that reduce sensitivity to pleiotropy. However, results from pleiotropy-robust analyses were less consistent, which limits the strength of causal inference. The work will be of interest to researchers studying cancer risk factors and genetic epidemiology.

Reviewed by eLife