1. Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

    This article has 26 authors:
    1. Amanda C Perofsky
    2. John Huddleston
    3. Chelsea Hansen
    4. John R Barnes
    5. Thomas Rowe
    6. Xiyan Xu
    7. Rebecca Kondor
    8. David E Wentworth
    9. Nicola Lewis
    10. Lynne Whittaker
    11. Burcu Ermetal
    12. Ruth Harvey
    13. Monica Galiano
    14. Rodney Stuart Daniels
    15. John W McCauley
    16. Seiichiro Fujisaki
    17. Kazuya Nakamura
    18. Noriko Kishida
    19. Shinji Watanabe
    20. Hideki Hasegawa
    21. Sheena G Sullivan
    22. Ian G Barr
    23. Kanta Subbarao
    24. Florian Krammer
    25. Trevor Bedford
    26. Cécile Viboud
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper explores the relationships among evolutionary and epidemiological quantities in influenza, and presents fundamental findings that substantially advance our understanding of the drivers of influenza epidemics. The authors use a rich set of data sources to gather and analyze compelling evidence on the roles of genetic distance, other influenza dynamics and epidemiological indicators in predicting influenza epidemics. The central findings highlight the significant influence of genetic distance on A(H3N2) virus epidemiology and emphasize the role of A(H1N1) virus incidence in shaping A(H3N2) epidemics, suggesting subtype interference as a key factor. This paper also makes relevant data available to the research community.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  2. Disentangling the relationship between cancer mortality and COVID-19 in the US

    This article has 3 authors:
    1. Chelsea L Hansen
    2. Cécile Viboud
    3. Lone Simonsen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable work explores death coding data to understand the impact of COVID-19 on cancer mortality. The work provides solid evidence that deaths with cancer as a contributing cause were not above what would be expected during pandemic waves, suggesting that cancer did not strongly increase the risk of dying of COVID-19. These results are an interesting exploration into the coding of causes of death that can be used to make sense of how deaths are coded during a pandemic in the presence of other underlying diseases, such as cancer.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 2 listsLatest version Latest activity
  3. SARS-CoV-2 correlates of protection from infection against variants of concern

    This article has 21 authors:
    1. Kaiyuan Sun
    2. Jinal N. Bhiman
    3. Stefano Tempia
    4. Jackie Kleynhans
    5. Vimbai Sharon Madzorera
    6. Qiniso Mkhize
    7. Haajira Kaldine
    8. Meredith L McMorrow
    9. Nicole Wolter
    10. Jocelyn Moyes
    11. Maimuna Carrim
    12. Neil A Martinson
    13. Kathleen Kahn
    14. Limakatso Lebina
    15. Jacques D. du Toit
    16. Thulisa Mkhencele
    17. Anne von Gottberg
    18. Cécile Viboud
    19. Penny L. Moore
    20. Cheryl Cohen
    21. PHIRST-C group

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  4. Systematic evaluation of multifactorial causal associations for Alzheimer's disease and an interactive platform based on Mendelian randomization analysis——MRAD

    This article has 6 authors:
    1. Tianyu Zhao
    2. Hui Li
    3. Meishuang Zhang
    4. Yang Xu
    5. Ming Zhang
    6. Li Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study introduces the MRAD database, which provides a useful tool for evaluating risk and protective factors for Alzheimer's disease through Mendelian randomization analysis. While the findings are supported by solid evidence, the study's value could be enhanced by addressing methodological concerns and ensuring rigorous validation of significant associations. The MRAD database has the potential to aid researchers and clinicians, but the current analysis appears incomplete without these refinements.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. Current Schistosoma mansoni exposure and infection have distinct determinants: a data-driven population-based study in rural Uganda

    This article has 6 authors:
    1. Fabian Reitzug
    2. Narcis B. Kabatereine
    3. Anatol M. Byaruhanga
    4. Fred Besigye
    5. Betty Nabatte
    6. Goylette F. Chami

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. Protection afforded by post-infection SARS-CoV-2 vaccine doses: a cohort study in Shanghai

    This article has 8 authors:
    1. Bo Zheng
    2. Bronner Gonçalves
    3. Pengfei Deng
    4. Weibing Wang
    5. Jie Tian
    6. xueyao Liang
    7. Ye Yao
    8. Caoyi Xue
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable work by Zheng and colleagues uses a large cohort database from Shanghai to identify that post-infection vaccination among previously vaccinated individuals provides significant low to moderate protection against re-infection. The evidence supporting the conclusion is solid with some limitations, e.g., lack of symptom severity as an outcome, no inclusion of time since infection as an independent variable, improper definitions of some key variables, difficult-to-interpret figures, and exclusion of key groups (infected and then vaccinated). This study will be of interest to vaccinologists, public health officials and clinicians.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. Hybrid immunity from SARS-CoV-2 infection and vaccination in Canadian adults: cohort study

    This article has 22 authors:
    1. Patrick E. Brown
    2. Sze Hang Fu
    3. Leslie Newcombe
    4. Xuyang Tang
    5. Nico Nagelkerke
    6. H Chaim Birnboim
    7. Aiyush Bansal
    8. Karen Colwill
    9. Geneviève Mailhot
    10. Melanie Delgado-Brand
    11. Tulunay Tursun
    12. Freda Qi
    13. Anne-Claude Gingras
    14. Arthur S. Slutsky
    15. Maria D. Pasic
    16. Jeffrey Companion
    17. Isaac I. Bogoch
    18. Ed Morawski
    19. Teresa Lam
    20. Angus Reid
    21. Prabhat Jha
    22. Ab-C Study Collaborators
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study assessed antibody levels, which are indicative of protection, resulting from both COVID-19 vaccination and natural infection in a representative sample of the Canadian population. The work provides solid evidence that Individuals who received a booster vaccination and had a prior infection had the highest antibody levels, particularly when either the vaccination or natural infection had occurred within the past six months. These findings are of fundamental importance in supporting the value of booster vaccination in populations vulnerable to severe COVID-19.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Estimating the reproduction number and transmission heterogeneity from the size distribution of clusters of identical pathogen sequences

    This article has 2 authors:
    1. Cécile Tran-Kiem
    2. Trevor Bedford

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  9. Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: A population-based cohort study in UK Biobank

    This article has 7 authors:
    1. Yuchen Zhang
    2. Yitang Sun
    3. Qi Yu
    4. Suhang Song
    5. J Thomas Brenna
    6. Ye Shen
    7. Kaixiong Ye
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript provides convincing evidence that both circulating omega-6 and omega-3 PUFAs are associated with lower all-cause, cancer, and cardiovascular mortality in the UK BioBank population and that omega-3s have a stronger effect than omega-6s. The findings have important public health implications.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. Design of the HPV-automated visual evaluation (PAVE) study: Validating a novel cervical screening strategy

    This article has 19 authors:
    1. Silvia de Sanjosé
    2. Rebecca B Perkins
    3. Nicole Campos
    4. Federica Inturrisi
    5. Didem Egemen
    6. Brian Befano
    7. Ana Cecilia Rodriguez
    8. Jose Jerónimo
    9. Li C Cheung
    10. Kanan Desai
    11. Paul Han
    12. Akiva P Novetsky
    13. Abigail Ukwuani
    14. Jenna Marcus
    15. Syed Rakin Ahmed
    16. Nicolas Wentzensen
    17. Jayashree Kalpathy-Cramer
    18. Mark Schiffman
    19. On behalf of the PAVE Study Group
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study will provide evidence about a novel screen-triage-treat strategy for cervical cancer prevention. The trial will generate convincing evidence regarding the efficacy, effectiveness, cost-effectiveness, feasibility and acceptability in a range of geographically spread low-resource settings. The strategy should contribute to improving access to cervical cancer prevention to vulnerable women with low access to health care, and, therefore, at the highest risk of cervical cancer.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity