Investigation of an ongoing outbreak of ceftriaxone-resistant Salmonella enterica serovar Typhi in Bangladesh

  1. Yogesh Hooda
  2. Arif Mohammad Tanmoy
  3. Sudipta Deb Nath
  4. Anannya Barman Jui
  5. Al Amin
  6. Hafizur Rahman
  7. Neoyman Nasir Shorkar
  8. Naito Kanon
  9. Md Asadur Rahman
  10. Denise O Garrett
  11. Mohammad Shahidul Islam
  12. ASM Nawshad Uddin Ahmed
  13. Samir K Saha
  14. Senjuti Saha
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Abstract

We report an outbreak of ceftriaxone-resistant Salmonella Typhi in Bangladesh, with 47 cases identified from April-September 2024. Isolates belong to genotype 4.3.1.2 and harbor the bla CTX- M-15 gene on the pCROB1 plasmid. This unique genotype-plasmid lineage represents a recent introduction, necessitating enhanced surveillance, antimicrobial stewardship, and consideration of vaccination strategies.

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  1. Version published to 10.1101/2024.12.24.24319600v1 on medRxiv