Investigation of an ongoing outbreak of ceftriaxone-resistant Salmonella enterica serovar Typhi in Bangladesh

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Abstract

We report an outbreak of ceftriaxone-resistant Salmonella Typhi in Bangladesh, with 47 cases identified from April-September 2024. Isolates belong to genotype 4.3.1.2 and harbor the bla CTX- M-15 gene on the pCROB1 plasmid. This unique genotype-plasmid lineage represents a recent introduction, necessitating enhanced surveillance, antimicrobial stewardship, and consideration of vaccination strategies.

Article activity feed

  1. Pham Thanh Duy

    Review 3: "Investigation of an Ongoing Outbreak of Ceftriaxone-Resistant Salmonella Enterica Serovar Typhi in Bangladesh"

    Reviewers emphasized the significance of public health, urging enhanced surveillance, treatment guideline updates, and consideration of typhoid vaccines.

  2. John Gunn, Peter Muturi

    Review 2: "Investigation of an Ongoing Outbreak of Ceftriaxone-Resistant Salmonella Enterica Serovar Typhi in Bangladesh"

    Reviewers emphasized the significance of public health, urging enhanced surveillance, treatment guideline updates, and consideration of typhoid vaccines.

  3. Hidemasa Izumiya

    Review 1: "Investigation of an Ongoing Outbreak of Ceftriaxone-Resistant Salmonella Enterica Serovar Typhi in Bangladesh"

    Reviewers emphasized the significance of public health, urging enhanced surveillance, treatment guideline updates, and consideration of typhoid vaccines.

  4. Strength of evidence

    Reviewer(s): H Izumiya (National Institute of Infectious Diseases, Tokyo) | 📗📗📗📗◻️
    J Gunn & P Muturi (The Ohio State University) | 📗📗📗📗◻️
    P T Duy (Oxford University Clinical Research Unit) | 📘📘📘📘📘