Developmental Biology

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochlea

1. Sandra de Haan
2. Agustin A. Corbat
3. Christopher R. Cederroth
4. Lisa G. Autrum
5. Simona Hankeova
6. Elizabeth C. Driver
7. Barbara Canlon
8. Matthew W. Kelley
9. Emma R. Andersson

Reviewed by Review Commons

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

1. Corey D Holman
2. Alexander P Sakers
3. Ryan P Calhoun
4. Lan Cheng
5. Ethan C Fein
6. Christopher Jacobs
7. Linus Tsai
8. Evan D Rosen
9. Patrick Seale

• Curated by eLife

  eLife assessment

  This fundamental study provides evidence that de novo beige adipogenesis from Pdgfra+ adipocyte progenitor cells is blocked during early aging in subcutaneous fat. The depth of the data at early ages is compelling, with rigorous cell tracing methodology employed. The study will aid in identifying new approaches to switch dormant adipocytes into an active thermogenic phenotype, and should be of interest to cell biologists at large.

Reviewed by eLife

A pre-vertebrate endodermal origin of calcitonin-producing neuroendocrine cells

1. Jenaid M. Rees
2. Katie Kirk
3. Giacomo Gattoni
4. Dorit Hockman
5. Dylan J. Ritter
6. Èlia Benito-Gutierrez
7. Ela W. Knapik
8. J. Gage Crump
9. Peter Fabian
10. J. Andrew Gillis

Reviewed by PREreview

Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind

1. F Javier DeHaro-Arbona
2. Charalambos Roussos
3. Sarah Baloul
4. Jonathan Townson
5. María J Gómez Lamarca
6. Sarah Bray

• Curated by eLife

  eLife assessment

  This fundamental study advances our understanding of how Notch signaling activates transcription by analyzing dynamics of the Mastermind transcriptional co-activator and its role in the activation complex. The evidence is compelling and based on state of the art methods with precise quantitative measurements.

Reviewed by eLife

ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism detecting alteration of septate junction integrity in Drosophila epithelial cells

1. Thomas Esmangart de Bournonville
2. Mariusz K Jaglarz
3. Emeline Durel
4. Roland Le Borgne

Reviewed by Review Commons

Spatio-temporal dynamics of early somite segmentation in the chicken embryo

1. Ana Cristina Maia-Fernandes
2. Ana Martins-Jesus
3. Nísia Borralho-Martins
4. Tomás Pais-de-Azevedo
5. Ramiro Magno
6. Isabel Duarte
7. Raquel P. Andrade

Reviewed by Review Commons

Robust axis elongation by Nodal-dependent restriction of BMP signaling

1. Alexandra Schauer
2. Kornelija Pranjic-Ferscha
3. Robert Hauschild
4. Carl-Philipp Heisenberg

Reviewed by Review Commons

Variations in cell plasticity and proliferation underlie distinct modes of regeneration along the antero-posterior axis in the annelid Platynereis

1. Loïc Bideau
2. Zoé Velasquillo-Ramirez
3. Loeiza Baduel
4. Marianne Basso
5. Pascale Gilardi-Hebenstreit
6. Vanessa Ribes
7. Michel Vervoort
8. Eve Gazave

Reviewed by Review Commons

The Fraser complex interconnects tissue layers to support basal epidermis and osteoblast integrated morphogenesis underlying fin skeletal patterning

1. Amy E. Robbins
2. Samuel G. Horst
3. Victor M. Lewis
4. Scott Stewart
5. Kryn Stankunas

Reviewed by Review Commons

PUFFFIN: an ultra-bright, customisable, single-plasmid system for labelling cell neighbourhoods

1. Tamina Lebek
2. Mattias Malaguti
3. Giulia LM Boezio
4. Lida Zoupi
5. James Briscoe
6. Alistair Elfick
7. Sally Lowell

Reviewed by Review Commons, preLights