Developmental Biology

An actin bracket-induced elastoplastic transition determines epithelial folding irreversibility

1. Aki Teranishi
2. Misato Mori
3. Rihoko Ichiki
4. Satoshi Toda
5. Go Shioi
6. Satoru Okuda

Reviewed by preLights

A revised single-cell transcriptomic atlas of Xenopus embryo reveals new differentiation dynamics

1. Kseniya Petrova
2. Maksym Tretiakov
3. Aleksandr Kotov
4. Anne H. Monsoro-Burq
5. Leonid Peshkin

Reviewed by preLights

Notch Is Required for Neural Progenitor Proliferation During Embryonic Eye Regrowth

1. Dylan J. Guerin
2. Belen Gutierrez
3. Baoyi Zhang
4. Kelly Ai-Sun Tseng

Reviewed by preLights

FoxO transcription factors actuate the formative pluripotency specific gene expression programme

1. Laura Santini
2. Saskia Kowald
3. Luis Miguel Cerron-Alvan
4. Michelle Huth
5. Anna Philina Fabing
6. Giovanni Sestini
7. Nicolas Rivron
8. Martin Leeb

Reviewed by preLights

Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis

1. Franziska Peters
2. Susanne Brodesser
3. Kai Kruse
4. Hannes C.A. Drexler
5. Jiali Hu
6. Dominika Lukas
7. Esther von Stebut
8. Martin Krönke
9. Carien M. Niessen
10. Sara A. Wickström

Reviewed by Review Commons

An important role for triglyceride in regulating spermatogenesis

1. Charlotte F Chao
2. Yanina-Yasmin Pesch
3. Huaxu Yu
4. Chenjingyi Wang
5. Maria J Aristizabal
6. Tao Huan
7. Guy Tanentzapf
8. Elizabeth Rideout

• Curated by eLife

  eLife assessment

  This important study identifies a role for triglycerides and lipid droplets in spermatogenesis, with data supporting relevance of this finding across phyla. The work shows with convincing data that a triglyceride lipase is required cell-autonomously for germline differentiation into meiotic stages and haploid spermatids and that an increase in triglycerides is detrimental to spermatogenesis. This paper would be of interest to developmental and cell biologists working on gametogenesis.

Reviewed by eLife

Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation

1. Rieko Asai
2. Vivek N Prakash
3. Shubham Sinha
4. Manu Prakash
5. Takashi Mikawa

• Curated by eLife

  eLife assessment

  Large scale cell movements occur during gastrulation in vertebrate embryos but their role in this major morphogenetic transition in formation of the body plan is poorly understood. Using the chick embryo model system, this study makes important advances using elegant methods to show that extension of the primitive streak during gastrulation, occurring through cell proliferation, polarisation and intercalation, and large-scale polonaise cell movements, can be uncoupled. Although the driving mechanism and precise role of these movements remains a mystery, the study provides convincing evidence for the uncoupling through independent approaches, the most creative of which are the effects shown after induction of a supernumerary primitive streak.

Reviewed by eLife

Gene expression differences associated with intrinsic hindfoot muscle loss in the jerboa, Jaculus jaculus

1. Mai P. Tran
2. Daniel Ochoa Reyes
3. Alexander J. Weitzel
4. Aditya Saxena
5. Michael Hiller
6. Kimberly L. Cooper

Reviewed by Arcadia Science

Lens placode modulates extracellular matrix formation during early eye development

1. Cecília G. De Magalhães
2. Ales Cvekl
3. Ruy G. Jaeger
4. C.Y. Irene Yan

Reviewed by preLights

FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility

1. Zhiming Li
2. Xingping Liu
3. Yan Zhang
4. Yuanyuan Li
5. Liquan Zhou
6. Shuiqiao Yuan

• Curated by eLife

  eLife assessment

  This important study provides insights into the role of FBXO24 in controlling spermiogenesis and male fertility in mice. The mouse models used and the data are convincing. This paper will interest biomedical researchers working on reproductive biology and fertility control.

Reviewed by eLife