Developmental Biology

  1. The rapidly evolving X-linked MIR-506 family fine-tunes spermatogenesis to enhance sperm competition

    1. Zhuqing Wang
    2. Yue Wang
    3. Tong Zhou
    4. Sheng Chen
    5. Dayton Morris
    6. Rubens Daniel Miserani Magalhães
    7. Musheng Li
    8. Shawn Wang
    9. Hetan Wang
    10. Yeming Xie
    11. Hayden McSwiggin
    12. Daniel Oliver
    13. Shuiqiao Yuan
    14. Huili Zheng
    15. Jaaved Mohammed
    16. Eric C Lai
    17. John R McCarrey
    18. Wei Yan

    • Curated by eLife

      eLife assessment

      This study provides important findings on the evolution and function of the X-linked miR-506 miRNA cluster. The evidence supporting the conclusions is convincing, including the generation and characterization of an impressive number of the miRNA deletion mutants. This work will be of interest to RNA biologists, evolution biologists and reproductive biologists.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  2. Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochlea

    1. Sandra de Haan
    2. Agustin A. Corbat
    3. Christopher R. Cederroth
    4. Lisa G. Autrum
    5. Simona Hankeova
    6. Elizabeth C. Driver
    7. Barbara Canlon
    8. Matthew W. Kelley
    9. Emma R. Andersson

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

    1. Corey D Holman
    2. Alexander P Sakers
    3. Ryan P Calhoun
    4. Lan Cheng
    5. Ethan C Fein
    6. Christopher Jacobs
    7. Linus Tsai
    8. Evan D Rosen
    9. Patrick Seale

    • Curated by eLife

      eLife assessment

      This fundamental study provides evidence that de novo beige adipogenesis from Pdgfra+ adipocyte progenitor cells is blocked during early aging in subcutaneous fat. The depth of the data at early ages is compelling, with rigorous cell tracing methodology employed. The study will aid in identifying new approaches to switch dormant adipocytes into an active thermogenic phenotype, and should be of interest to cell biologists at large.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  4. A pre-vertebrate endodermal origin of calcitonin-producing neuroendocrine cells

    1. Jenaid M. Rees
    2. Katie Kirk
    3. Giacomo Gattoni
    4. Dorit Hockman
    5. Dylan J. Ritter
    6. Èlia Benito-Gutierrez
    7. Ela W. Knapik
    8. J. Gage Crump
    9. Peter Fabian
    10. J. Andrew Gillis

    Reviewed by PREreview

    1 evaluationAppears in 2 listsLatest version Latest activity

  5. Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind

    1. F Javier DeHaro-Arbona
    2. Charalambos Roussos
    3. Sarah Baloul
    4. Jonathan Townson
    5. María J Gómez Lamarca
    6. Sarah Bray

    • Curated by eLife

      eLife assessment

      This fundamental study advances our understanding of how Notch signaling activates transcription by analyzing dynamics of the Mastermind transcriptional co-activator and its role in the activation complex. The evidence is compelling and based on state of the art methods with precise quantitative measurements.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  6. ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism detecting alteration of septate junction integrity in Drosophila epithelial cells

    1. Thomas Esmangart de Bournonville
    2. Mariusz K Jaglarz
    3. Emeline Durel
    4. Roland Le Borgne

    Reviewed by Review Commons

    8 evaluationsAppears in 1 listLatest version Latest activity

  7. Spatio-temporal dynamics of early somite segmentation in the chicken embryo

    1. Ana Cristina Maia-Fernandes
    2. Ana Martins-Jesus
    3. Nísia Borralho-Martins
    4. Tomás Pais-de-Azevedo
    5. Ramiro Magno
    6. Isabel Duarte
    7. Raquel P. Andrade

    Reviewed by Review Commons

    8 evaluationsAppears in 1 listLatest version Latest activity

  8. Robust axis elongation by Nodal-dependent restriction of BMP signaling

    1. Alexandra Schauer
    2. Kornelija Pranjic-Ferscha
    3. Robert Hauschild
    4. Carl-Philipp Heisenberg

    Reviewed by Review Commons

    8 evaluationsAppears in 1 listLatest version Latest activity

  9. Variations in cell plasticity and proliferation underlie distinct modes of regeneration along the antero-posterior axis in the annelid Platynereis

    1. Loïc Bideau
    2. Zoé Velasquillo-Ramirez
    3. Loeiza Baduel
    4. Marianne Basso
    5. Pascale Gilardi-Hebenstreit
    6. Vanessa Ribes
    7. Michel Vervoort
    8. Eve Gazave

    Reviewed by Review Commons

    8 evaluationsAppears in 1 listLatest version Latest activity

  10. The Fraser complex interconnects tissue layers to support basal epidermis and osteoblast integrated morphogenesis underlying fin skeletal patterning

    1. Amy E. Robbins
    2. Samuel G. Horst
    3. Victor M. Lewis
    4. Scott Stewart
    5. Kryn Stankunas

    Reviewed by Review Commons

    8 evaluationsAppears in 1 listLatest version Latest activity
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