Developmental Biology

The retinoic acid receptor regulates development of a key evolutionary novelty - the molluscan shell

1. Keisuke Shimizu
2. Paul A. O’Neill
3. Kazuyoshi Endo
4. Tetsuhiro Kudoh

Reviewed by Arcadia Science

Prenatal exposure to environmental stressors alters gut macrophage development and gastrointestinal function of male offspring

1. Dang M. Nguyen
2. Sarah K. Monroe
3. Danielle N. Rendina
4. Kevin S. Boyd
5. Erika D. Rispoli
6. Olivia M. Wirfel
7. A. Brayan Campos-Salazar
8. Anna R. Araujo
9. Trisha V. Vaidyanathan
10. Virginia L. Keziah
11. Benjamin A. Devlin
12. Caroline J. Smith
13. Staci D. Bilbo

Reviewed by preLights

Site-specific DNA demethylation during spermatogenesis presets the sites of nucleosome retention in mouse sperm

1. So Maezawa
2. Masashi Yukawa
3. Akihiko Sakashita
4. Artem Barski
5. Satoshi H Namekawa

• Curated by eLife

  eLife Assessment

  This study provides valuable findings on the role of site-specific DNA methylation changes during spermatogenesis and their contribution to paternal epigenetic inheritance. The study proposes that selective loss of DNA methylation at a subset of promoters is required for nucleosome retention and the establishment of epigenetic states that may influence embryonic gene regulation. The present study's conclusion is mostly supported by solid data.

Reviewed by eLife

SRSF3 is a key regulator of epicardial formation

1. Irina-Elena Lupu
2. Susann Bruche
3. Anob M. Chakrabarti
4. Ian R. McCracken
5. Tamara Carsana
6. Andia N. Redpath
7. Nicola Smart

Reviewed by Review Commons

Pleiotropic function of Dlx5/6 in coordinating the development of mammalian vocal and auditory organs

1. Frida Sánchez-Garrido
2. Victoria Bouzerand
3. Markéta Kaiser
4. Chloé Chaumeton
5. Anastasia Fontaine
6. Tomáš Zikmund
7. Jozef Kaiser
8. Églantine Heude

Reviewed by Review Commons

Single-cell transcriptomes of zebrafish germline reveal progenitor types and feminization by Foxl2l

1. Chen-wei Hsu
2. Hao Ho
3. Ching-Hsin Yang
4. Yan-wei Wang
5. Ker-Chau Li
6. Bon-chu Chung

• Curated by eLife

  eLife Assessment

  This manuscript provides important findings for understanding the mechanisms of a major gene causing the gonad of fish and other vertebrates, including mammals, to become an ovary rather than a testis. Evidence is solid, but alternative explanations for a number of the claims must be considered and discussed. The impact of the work would benefit by placing it in a richer historical context.

Reviewed by eLife

Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development

1. Qian Wang
2. Hongge Li
3. Yingyu Mao
4. Ankur Garg
5. Eun Sil Park
6. Yihua Wu
7. Alyssa Chow
8. John Peregrin
9. Xin Zhang

• Curated by eLife

  eLife Assessment

  This fundamental article significantly advances our understanding of FGF signalling, and in particular highlights the complex modifications affecting this pathway. The evidence for the authors' claims is convincing, combining state of the art conditional gene deletion in the mouse lens with histological and molecular approaches. This work should be of great interest to molecular and developmental biologists beyond the lens community.

Reviewed by eLife

MMP21 behaves as a fluid flow transported morphogen to impart laterality during development

1. Tim Ott
2. Amelie Brugger
3. Emmanuelle Szenker-Ravi
4. Yvonne Kurrle
5. Olivia Aberle
6. Matthias Tisler
7. Martin Blum
8. Sandra Whalen
9. Patrice Bouvagnet
10. Bruno Reversade
11. Axel Schweickert

• Curated by eLife

  eLife Assessment

  This report explores the role of matrix metalloprotease MMP21 in left-right patterning in Xenopus. Based on a series of compelling experiments, the authors demonstrate that MMP21 can be secreted and acts upstream of dand5 without affecting cilia flow. The experiments are interesting and valuable; however, the claims by the authors lack consideration of other models that could also explain their findings.

Reviewed by eLife

Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut

1. Mengjie Li
2. Aiguo Tian
3. Jin Jiang

• Curated by eLife

  eLife Assessment

  The authors examine the role of Numb, a Notch inhibitor, in intestinal stem cell self-renewal in Drosophila during homeostasis and regeneration. The significance is important as the authors demonstrate the ISC maintenance is reduced when both BMP signaling and Numb expression is reduced. The strength of evidence is convincing as large sample sizes and statistical analyses are provided.

Reviewed by eLife

Conserved interhemispheric morphogenesis in amniotes preceded the evolution of the corpus callosum

1. Ryota Noji
2. Mari Kaneko
3. Takaya Abe
4. Hiroshi Kiyonari
5. Yukihiro Nishikawa
6. Takuma Kumamoto
7. Hitoshi Gotoh
8. Chiaki Ohtaka-Maruyama
9. Katsuhiko Ono
10. Tatsuya Yoshizawa
11. Tadashi Nomura

Reviewed by Review Commons