Developmental Biology

TET knockout cells transit between pluripotent states and exhibit precocious germline entry

1. Raphaël Pantier
2. Elisa Barbieri
3. Sara Gonzalez Brito
4. Ella Thomson
5. Tülin Tatar
6. Douglas Colby
7. Man Zhang
8. Ian Chambers

Reviewed by preLights

Synergistic and independent roles for Nodal and FGF in zebrafish cardiac progenitor cell migration and asymmetric heart morphogenesis

1. Vanessa Gonzalez
2. Meagan G. Grant
3. Makoto Suzuki
4. Briana Christophers
5. Jessica Rowland Williams
6. Rebecca D. Burdine

Reviewed by preLights

SoxB1 family members inhibit Wnt signaling to promote maturation and deposition of stable neuromasts by the zebrafish Posterior Lateral Line primordium

1. Greg Palardy
2. Kyeong-won Yoo
3. Sana Fatma
4. Abhishek Mukherjee
5. Chongmin Wang
6. Priyanka Ravi
7. Ajay B Chitnis

• Curated by eLife

  eLife Assessment

  This important study explores the regulation of collective cell migration and tissue patterning in the zebrafish posterior lateral line primordium by SoxB1 transcription factors. The authors provide evidence that SoxB1 genes interact with Wnt and Fgf signaling pathways to control neuromast deposition and spacing, a process central to sensory organ development. The work offers mechanistic insight into the self-organization of migrating tissues and adds to the understanding of how transcriptional networks integrate with signaling pathways during morphogenesis. However, the strength of the evidence supporting several key conclusions is incomplete due to insufficient validation of mutant and knockdown tools, lack of quantitative analysis, and unclear experimental design details; additional quantification and more rigorous verification of gene knockdown or loss-of-function tools are needed to support the proposed model.

Reviewed by eLife

A conserved RNA switch for acetylcholine receptor clustering at neuromuscular junctions in chordates

1. Md. Faruk Hossain
2. Sydney Popsuj
3. Burcu Vitrinel
4. Nicole A. Kaplan
5. Alberto Stolfi
6. Lionel Christiaen
7. Matteo Ruggiu

Reviewed by Review Commons

Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells

1. Robert N Rainey
2. Sam D Houman
3. Louise Menendez
4. Ryan Chang
5. Litao Tao
6. Helena Bugacov
7. Andrew P McMahon
8. Radha Kalluri
9. John S Oghalai
10. Andrew K Groves
11. Neil Segil

• Curated by eLife

  eLife Assessment

  The findings of this important study substantially advance our understanding of the transcription factors that can induce hair cell-like cells from human pluripotent stem cells. The presented evidence supporting these findings is compelling, including rigorous characterization of the effects of hair cell induction using both single-cell RNA sequencing and electrophysiological assessments.

Reviewed by eLife