Developmental Biology

map3k1 is required for spatial restriction of progenitor differentiation in planarians

1. Bryanna Isela-Inez Canales
2. Hunter O King
3. Peter W Reddien

• Curated by eLife

  eLife Assessment

  This valuable study examines the role of map3k1, a MAP3K family member that has both kinase and ubiquitin ligase domains, in the differentiation of progenitors in the flatworm Planaria. The convincing analyses demonstrate that map3k1 acts within progenitors to restrict their premature differentiation and to prevent formation of teratomas. This work would be of interest to researchers in the fields of regeneration, developmental biology, and aging.

Reviewed by eLife

Changes in neural progenitor lineage composition during astrocytic differentiation of human iPSCs

1. Zongze Li
2. Lucia Fernandez Cardo
3. Michal Rokicki
4. Jimena Monzón-Sandoval
5. Viola Volpato
6. Frank Wessely
7. Caleb Webber
8. Meng Li

• Curated by eLife

  eLife Assessment

  The manuscript by Li and coworkers analyzed astrocytic differentiation of midbrain floor plate-patterned neural cells originating from human iPS cells, with a LMX1A reporter. This valuable work identifies transcriptomic differences at the single-cell level, between astrocytes generated from LMX1A reporter positive or negative cells, as well as non-patterned astrocytes and neurons. The evidence is solid, but the paper can be strengthened by further analyses of the transcriptomic data, and astrocytic morphology; also, searching for some of the differentially expressed genes by immunohistochemistry in different regions of the mammalian brain, or in human specimens, would be very informative.

Reviewed by eLife

Different cellular and molecular mechanisms of chitin deposition contribute to the specificity of the two chitin synthases in D. melanogaster

1. Joan Bertran-Mas
2. Ettore De Giorgio
3. Nicolás Martín
4. Marta Llimargas

Reviewed by Review Commons

Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing

1. Madeline M Keenen
2. Liheng Yang
3. Huan Liang
4. Veronica J Farmer
5. Rizban E Worota
6. Rohit Singh
7. Amy S Gladfelter
8. Carolyn B Coyne

• Curated by eLife

  eLife Assessment

  This important study uses single-cell transcriptomics to analyze syncytiotrophoblasts in two trophoblast organoid models compared to primary placental tissue, providing compelling insights into syncytialization and highlighting the utility of organoid models in placental research. It also serves as an invaluable resource for the field.

Reviewed by eLife

The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice

1. Soomin Cho
2. Emilia Servián-Morilla
3. Victoria Navarro Garrido
4. Beatriz Rodriguez-Gonzalez
5. Youxi Yuan
6. Raquel Cano
7. Arjun A. Rambhiya
8. Radbod Darabi
9. Robert S. Haltiwanger
10. Carmen Paradas
11. Hamed Jafar-Nejad

Reviewed by Review Commons

Ecdysone-mediated intestinal growth contributes to microbiota-driven developmental plasticity under malnutrition

1. Longwei Bai
2. Stéphanie Bellemin
3. Elodie Guillemot
4. Maura Strigini
5. Benjamin Gillet
6. Cathy Isaura Ramos
7. François Leulier

Reviewed by Review Commons

Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila

1. Pengzhen Dong
2. Yue Li
3. Yuying Wang
4. Qiang Zhao
5. Tianfeng Lu
6. Jian Chen
7. Tianyu Guo
8. Jun Ma
9. Bing Yang
10. Honggang Wu
11. Hai Huang

• Curated by eLife

  eLife Assessment

  This valuable study investigates how inter-organ communication between the tracheal stem cells and the fat body plays a key role in the directed migration of tracheal stem cells in Drosophila pupae. The evidence supporting the conclusions is convincing. The work would be of broad interest to researchers in the fields of developmental biology and cancer biology.

Reviewed by eLife

Wnt signaling restores evolutionary loss of regenerative potential in Hydra

1. Sergio E. Campos
2. Sahar Naziri
3. Jackson Crane
4. Jennifer Tsverov
5. Ben D. Cox
6. Craig Ciampa
7. Celina E. Juliano

Reviewed by preLights

CHD3 regulates BMP signalling response during cranial neural crest cell specification

1. Zoe H. Mitchell
2. Joery den Hoed
3. Willemijn Claassen
4. Martina Demurtas
5. Laura Deelen
6. Philippe M. Campeau
7. Karen Liu
8. Simon E. Fisher
9. Marco Trizzino

Reviewed by Review Commons

Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system

1. Ozanna Burnicka-Turek
2. Katy A Trampel
3. Brigitte Laforest
4. Michael T Broman
5. Xinan H Yang
6. Zoheb Khan
7. Eric Rytkin
8. Binjie Li
9. Ella Schaffer
10. Margaret Gadek
11. Kaitlyn M Shen
12. Igor R Efimov
13. Ivan P Moskowitz

• Curated by eLife

  eLife Assessment

  The work presented is important for our understanding of the development of the cardiac conduction system and its regulation by T-box transcription factors. The conclusions are supported by convincing data. Overall this is an excellent study that advances our understanding of cardiac biology and has implications beyond the immediate field of study.

Reviewed by eLife