Developmental Biology

Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut

1. Mengjie Li
2. Aiguo Tian
3. Jin Jiang

• Curated by eLife

  eLife Assessment

  The authors examine the role of Numb, a Notch inhibitor, in intestinal stem cell self-renewal in Drosophila during homeostasis and regeneration. The significance is important as the authors demonstrate the ISC maintenance is reduced when both BMP signaling and Numb expression is reduced. The strength of evidence is convincing as large sample sizes and statistical analyses are provided.

Reviewed by eLife

Conserved interhemispheric morphogenesis in amniotes preceded the evolution of the corpus callosum

1. Ryota Noji
2. Mari Kaneko
3. Takaya Abe
4. Hiroshi Kiyonari
5. Yukihiro Nishikawa
6. Takuma Kumamoto
7. Hitoshi Gotoh
8. Chiaki Ohtaka-Maruyama
9. Katsuhiko Ono
10. Tatsuya Yoshizawa
11. Tadashi Nomura

Reviewed by Review Commons

Oviductin sets the species-specificity of the mammalian zona pellucida

1. Daniel de la Fuente
2. Maria Maroto
3. Yulia N Cajas
4. Karina Canon-Beltran
5. Raul Fernandez-Gonzalez
6. Ana Munoz-Maceda
7. Juana M Sanchez-Puig
8. Rafael Blasco
9. Paula Cots-Rodríguez
10. Manuel Avilés
11. Dimitrios Rizos
12. Alfonso Gutierrez-Adan

• Curated by eLife

  eLife Assessment

  This valuable study unravels the mechanisms underlying mammalian sperm-oocyte recognition and penetration, shedding light on cross-species interactions. It provides solid evidence that exposure of sperm to oviductal fluid or OVGP1 proteins from bovine, murine, or human sources imparts species-specific zona pellucida (ZP) recognition, ensuring that only sperm from the corresponding species can penetrate the ZP, regardless of its origin. These findings hold significant potential for reproductive biology, offering insights to enhance porcine in vitro fertilization (IVF), which frequently suffers from polyspermy, as well as advancing human IVF through improved intrinsic sperm selection.

Reviewed by eLife

Identification of Specialized tRNA Expression in Early Human Brain Development

1. Alex L. Bagi
2. Todd M. Lowe
3. Sofie R. Salama

Reviewed by Life Science Editors Foundation

Ectopic head regeneration after nervous system ablation in a sea anemone

1. Fatemeh Mazloumi Gavgani
2. Johanna E.M. Kraus
3. Joshua November
4. Layla Al-Shaer
5. Anna Cosima Seybold
6. Benjamin Lerstad
7. Harald Hausen
8. Michael J. Layden
9. Fabian Rentzsch

Reviewed by preLights

Temporally resolved single cell transcriptomics in a human model of amniogenesis

1. Nikola Sekulovski
2. Amber E Carleton
3. Anusha A Rengarajan
4. Chien-Wei Lin
5. Lauren L Juga
6. Allison E Whorton
7. Jenna Kropp Schmidt
8. Thaddeus Golos
9. Kenichiro Taniguchi

Reviewed by Review Commons

Hyaluronic Acid and Emergent Tissue Mechanics Orchestrate Digit Tip Regeneration

1. Byron W.H. Mui
2. Joseph Y. Wong
3. Toni Bray
4. Lauren Connolly
5. Jia Hua Wang
6. Alexander Winkel
7. Pamela G. Robey
8. Kristian Franze
9. Kevin J. Chalut
10. Mekayla A. Storer

Reviewed by preLights

Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

1. Mehmet Mahsum Kaplan
2. Erika Hudacova
3. Miroslav Matejcek
4. Haneen Tuaima
5. Jan Křivánek
6. Ondrej Machon

• Curated by eLife

  eLife Assessment

  This study provides valuable insight into the role of Meis2 in whisker hair follicle formation and confirms prior work that nerves are dispensable for this process. The solid imaging techniques support the authors' conclusions, however the data provides limited evidence to support the mechanism of Meis2 in whisker formation.

Reviewed by eLife

A Dual Role for the PP2A Phosphatase in Hippo Signalling Regulation

1. Aashika Sekar
2. Alberto Rizzo
3. Elodie Sins
4. Alexander D. Fulford
5. Paulo S. Ribeiro

Reviewed by Review Commons

Mac/Lac-tosylceramide regulates intestinal homeostasis and secretory cell fate commitment by facilitating Notch signaling

1. Kebei Tang
2. Xuewen Li
3. Jiulong Hu
4. Jingyuan Shi
5. Yumei Li
6. Yansu Chen
7. Chang Yin
8. Fengchao Wang
9. Rongwen Xi

• Curated by eLife

  eLife Assessment

  This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal cells. Mutations in GlcT compromise Notch signaling in the Drosophila intestinal stem cell lineage resulting in the formation of enteroendocrine tumors, and preliminary data suggests that a homolog of glucosylceramide synthase also influences Notch signaling in the mammalian intestine. While the outstanding strengths of the initial genetic and downstream pathway analyses are noted, there are weaknesses in the data regarding the potential role of this pathway in Delta trafficking. Nevertheless, this study opens the way for future mechanistic studies addressing how specific lipids modulate Notch signalling activity.

Reviewed by eLife