Cell Biology

Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in C. elegans

1. Lingxiu Xu
2. Chengxuan Han
3. Lei Chun
4. XZ Shawn Xu
5. Jianfeng Liu

• Curated by eLife

  eLife Assessment

  This is an important study that addresses the temporal aspects of cell non-autonomous regulation of lifespan. It demonstrates that the same neurons and neurotransmitter have distinct impacts on longevity at different ages. The data convincingly supports the authors' claims.

Reviewed by eLife

Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes

1. Elisa Gomez-Gil
2. Paolo Guerra
3. Ying Gu
4. Sherman Foo
5. Benedicte Billard
6. Gabor Balogh
7. Maria Peter
8. Snezhana Oliferenko

Reviewed by Arcadia Science

Short chain fatty acids regulate the chromatin landscape and distinct gene expression changes in human colorectal cancer cells

1. Tohfa Kabir
2. Charlotte A. Connamacher
3. Zara Nadeem
4. Matthew R. Paul
5. Matthew R. Smutny
6. Zoe K. Lawler
7. Annaelle M. Djomo
8. Thomas S. Carroll
9. Leah A. Gates

Reviewed by Review Commons

Synergistic effects of deleting the tyrosine phosphatases Shp1 and Shp2 on megakaryopoiesis and thrombopoiesis in mice

1. Elsa Barré
2. Marc-Damien Lourenco-Rodrigues
3. Lucie Zimmermann
4. Marion Pugliano
5. Cécile Loubière
6. Fabienne Proamer
7. Jean-Yves Rinckel
8. Anita Eckly
9. Zihan Qu
10. Jinmin Miao
11. Zhong-Yin Zhang
12. Yotis A Senis
13. Alexandra Mazharian

• Curated by eLife

  eLife assessment

  This manuscript provides an important contribution to the field of platelet biogenesis, and the convincing evidence will advance our understanding of signal transduction driving the development of late megakaryopoiesis and platelet reactivity that results in bleeding diathesis. The paper is noteworthy for analyzing two related, either singly or in combination, tyrosine phosphatases in this conditional, stage development gene knockout. Because SHP1 is a negative regulator and SHP2 is an activator, the synergistic effects found in the double knockout were surprising.

Reviewed by eLife

Structural insights into mitotic-centrosome assembly

1. Nada Mohamad
2. Siu-Shing Wong
3. Anupa Majumdar
4. Alan Wainman
5. Ingelise Holland-Kaye
6. Lars Hubatsch
7. Zsofia Novak
8. Andrey Pozniakovsky
9. Martine Ruer-Gruss
10. Andreas F.M. Haensele
11. Anna Caballe
12. Steven Johnson
13. Susan M. Lea
14. Anthony Hyman
15. Jordan W. Raff

Reviewed by Review Commons

ATG2A engages RAB1A and ARFGAP1 positive membranes during autophagosome biogenesis

1. Devin M Fuller
2. Yumei Wu
3. Florian Schueder
4. Burha Rasool
5. Shanta Nag
6. Justin L Korfhage
7. Rolando Garcia-Milian
8. Katerina D Melnyk
9. Joerg Bewersdorf
10. Pietro De Camilli
11. Thomas J Melia

• Curated by eLife

  eLife Assessment

  This study provides important insights into the crosstalk between ATG2A with components of the early secretory pathway. While the mechanisms governing autophagic membrane expansion remain yet to be fully understood, in this study the authors employ an elegant proximity labelling approach and identify two ER-Golgi intermediate compartment (ERGIC)-localized proteins. Through a series of complementary experiments combining microscopy and biochemistry, the authors identify ARFGAP1 and Rab1A as components of early autophagic membranes, which accumulate at the periphery of pre-autophagosomal structures induced by loss of ATG2. The overall study is well executed and the evidence supporting the claims is convincing.

Reviewed by eLife