Cell Biology

Morphogen-driven human iPSCs differentiation in 3D in vitro models of gastrulation is precluded by physical confinement

1. Haneen S. Alsehli
2. Errin Roy
3. Thomas Williams
4. Alicja Kuziola
5. Yunzhe Guo
6. Jeremy Green
7. Eileen Gentleman
8. Davide Danovi

Reviewed by Review Commons

Bridge-like lipid transfer protein family member 2 suppresses ciliogenesis

1. Jan Parolek
2. Christopher G. Burd

Reviewed by Review Commons

Liver regeneration by a population of midzone-located mesenchymal-hepatocyte hybrid cells

1. Guo Yu
2. Shaoyang Zhang
3. Ana Romo
4. Soma Biswas
5. Baojie Li
6. Jing Li

• Curated by eLife

  eLife assessment

  This study is partly useful as it corroborates what is already known about the elevated proliferation capacity of mid lobular hepatocytes in liver regeneration. Lineage tracing and scRNAseq studies are powerful for the investigation of such heterogeneous hepatocyte proliferation capacity. Nevertheless, based on experimental limitations, incomplete method description and inadequate data analyses the presented data are insufficient to support the proposed conclusions of a mesenchymal-hepatocyte hybrid population in the murine liver.

Reviewed by eLife

CDK-4 regulates nucleolar size and metabolism at the cost of late-life fitness in C. elegans

1. Rachel Webster
2. Maria Quintana
3. Bin Yu
4. Stacey Fluke
5. Ran Kafri
6. W. Brent Derry

Reviewed by Arcadia Science

Excess microtubule and F-actin formation mediates shortening and loss of primary cilia in response to a hyperosmotic milieu

1. Hiroshi Otani
2. Ryota Nakazato
3. Kanae Koike
4. Keisuke Ohta
5. Koji Ikegami

Reviewed by Arcadia Science

Autoacetylation-mediated phase separation of TIP60 is critical for its functions

1. Shraddha Dubey
2. Himanshu Gupta
3. Ashish Gupta

• Curated by eLife

  eLife assessment

  This is a valuable study on K187 acetylation of the nuclear protein, TIP60, required for its phase separation and function. The evidence supporting the primary conclusion is incomplete and warrants more scrutiny.

Reviewed by eLife

CEP44 is required for maintaining centriole duplication and spindle integrity

1. Donghui Zhang
2. Wenlu Wei
3. Xiaopeng Zou
4. Hui Meng
5. Fangyuan Li
6. Minjun Yao
7. Junling Teng
8. Ning Huang
9. Jianguo Chen

• Curated by eLife

  eLife assessment

  This useful study investigates the role of the centrosomal protein CEP44 in centriole duplication and mitotic spindle formation. While the analysis of CEP44 mitotic phosphorylation and spindle recruitment is solid, the characterization of CEP44's role at centrioles is incomplete and would benefit from additional controls and analyses. Since the work links CEP44 reduced expression to poor survival in breast cancer patients, it is of interest not only to cell biologists but also to cancer researchers.

Reviewed by eLife