Cell Biology

The CUL4-DDB1-DCAF1 E3 ubiquitin ligase complex regulates PLK4 protein levels to prevent premature centriole duplication

1. Josina Grossmann
2. Anne-Sophie Kratz
3. Alina Kordonsky
4. Gali Prag
5. Ingrid Hoffmann

Reviewed by Review Commons

Neutral evolution of snoRNA Host Gene long non-coding RNA affects cell fate control

1. Matteo Vietri Rudan
2. Kalle H Sipilä
3. Christina Philippeos
4. Clarisse Ganier
5. Priyanka G Bhosale
6. Victor A Negri
7. Fiona M Watt

Reviewed by Review Commons

FAM134B regulates ER-to-lysosome-associated degradation of misfolded proteins upon pharmacologic or genetic inactivation of ER-associated degradation

1. Elisa Fasana
2. Ilaria Fregno
3. Carmela Galli
4. Maurizio Molinari

Reviewed by Review Commons

Mapping variation in the morphological landscape of human cells with optical pooled CRISPRi screening

1. Ramon Lorenzo D. Labitigan
2. Adrian L. Sanborn
3. Cynthia V. Hao
4. Caleb K. Chan
5. Nathan M. Belliveau
6. Eva M. Brown
7. Mansi Mehrotra
8. Julie A. Theriot

• Curated by eLife

  eLife assessment

  In this important study by Theriot et al., the authors utilize an impressive set of innovative approaches to conduct a CRISPRi pooled screen in human cells using large-scale microscopy screen data. They leverage an improved barcoding approach to identify genes targeted in specific cells and examine the effects on cell morphology using high-dimensional phenotypic analysis. The method and data presented are compelling.

Reviewed by eLife

Morphogen-driven human iPSCs differentiation in 3D in vitro models of gastrulation is precluded by physical confinement

1. Haneen S. Alsehli
2. Errin Roy
3. Thomas Williams
4. Alicja Kuziola
5. Yunzhe Guo
6. Jeremy Green
7. Eileen Gentleman
8. Davide Danovi

Reviewed by Review Commons

Bridge-like lipid transfer protein family member 2 suppresses ciliogenesis

1. Jan Parolek
2. Christopher G. Burd

Reviewed by Review Commons