Cell Biology

Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase

1. Léonard Colin
2. Celine Reyes
3. Julien Berthezene
4. Laetitia Maestroni
5. Laurent Modolo
6. Esther Toselli
7. Nicolas Chanard
8. Stephane Schaak
9. Olivier Cuvier
10. Yannick Gachet
11. Stephane Coulon
12. Pascal Bernard
13. Sylvie Tournier

• Curated by eLife

  eLife assessment

  This is an important study that characterises the involvement of condensin complexes in the segregation of telomeres in fission yeast. The authors present convincing evidence to support their claims, employing a diverse range of complementary techniques. This research will be of interest to cell biologists working on chromosome biology and cell division.

Reviewed by eLife

Systemic Lupus Erythematosus Serum Stimulation of Human Intestinal Organoids Induces Changes in Goblet Cell Differentiation and Mitochondrial Fitness

1. Inga Viktoria Hensel
2. Szabolcs Éliás
3. Michelle Steinhauer
4. Bilgenaz Stoll
5. Salvatore Benfatto
6. Wolfgang Merkt
7. Stefan Krienke
8. Hanns-Martin Lorenz
9. Jürgen Haas
10. Brigitte Wildeman
11. Martin Resnik-Docampo

Reviewed by Review Commons

Replisome loading reduces chromatin motion independent of DNA synthesis

1. Maruthi Kumar Pabba
2. Christian Ritter
3. Vadim O Chagin
4. Janis Meyer
5. Kerem Celikay
6. Jeffrey H Stear
7. Dinah Loerke
8. Ksenia Kolobynina
9. Paulina Prorok
10. Alice Kristin Schmid
11. Heinrich Leonhardt
12. Karl Rohr
13. M Cristina Cardoso

• Curated by eLife

  eLife assessment

  This is a valuable investigation of the chromatin dynamics throughout the cell cycle by using fluorescence signals and patterns of GFP-PCNA and CY3-dUTP, which labels newly synthesized DNA. The authors report reduced chromatin mobility in S relative to G1 phase. The technology and methods used are solid. The data will be of interest to researchers working on chromatin dynamics.

Reviewed by eLife

β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

1. Carole Daly
2. Akim Abdul Guseinov
3. Hyunggu Hahn
4. Adam Wright
5. Irina G Tikhonova
6. Alex Rojas Bie Thomsen
7. Bianca Plouffe

• Curated by eLife

  eLife assessment

  This is an important study that contributes to our understanding of the role of beta-arrestins in endosomal activation of the vasopressin type 2 receptors. While the use of a minigene as a tool is a weakness, the evidence is overall convincing and makes for significant findings whose theoretical and practical implications extend to other GPCRs.

Reviewed by eLife

Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

1. Yufang Ding
2. Karin Yanagi
3. Fang Yang
4. Evelyn Callaway
5. Clint Cheng
6. Martha E Hensel
7. Rani Menon
8. Robert C Alaniz
9. Kyongbum Lee
10. Arul Jayaraman

• Curated by eLife

  eLife assessment

  The studies are important to the field of hepatic steatosis and inflammation. The data provided are convincing that treatment with I3A mitigated Western diet (WD)-induced hepatic steatosis, inflammation and reversed WD-induced alterations in liver bile acids and free fatty acids in mice.

Reviewed by eLife

Development and validation of a high throughput screening platform to enable target identification in skeletal muscle cells from Duchenne Muscular Dystrophy (DMD) patients

1. Santosh Hariharan
2. Oana Lorintiu
3. Chia-Chin Lee
4. Eve Duchemin-Pelletier
5. Xianfeng Li
6. Aileen Healy
7. Regis Doyonnas
8. Luc Selig
9. Pauline Poydenot
10. Erwann Ventre
11. Andrea Weston
12. Jane Owens
13. Nicolas Christoforou

• Curated by eLife

  eLife assessment

  This is a solid methods paper developing a machine learning based protocol differentiating normal and diseased myofibers. It emerges with and validates a potentially valuable approach to diifferentiate healthy and Duchenne muscle dystrophy myofibers.

Reviewed by eLife

Crosstalk between the plasma membrane and cell-cell adhesion maintains epithelial identity for correct polarised cell divisions

1. Manal M. Hosawi
2. Jiaoqi Cheng
3. Maria Fankhaenel
4. Marcin R. Przewloka
5. Salah Elias

Reviewed by Review Commons

Phosphorylation-dependent interactions of VAPB and ELYS contribute to the temporal progression of mitosis

1. Christina James
2. Ulrike Möller
3. Sabine König
4. Henning Urlaub
5. Ralph H. Kehlenbach

Reviewed by Review Commons

Remodeling of the secretory pathway is coordinated with de novo membrane formation in budding yeast gametogenesis

1. Yasuyuki Suda
2. Hiroyuki Tachikawa
3. Tomomi Suda
4. Kazuo Kurokawa
5. Akihiko Nakano
6. Kenji Irie

Reviewed by Review Commons

Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia

1. Marta Bicka
2. Corbin Black
3. Avrin Ghanaeian
4. Ewa Joachimiak
5. Anna Osinka
6. Sumita Majhi
7. Anna Konopka
8. Ewa Bulska
9. Khanh Huy Bui
10. Dorota Wloga

• Curated by eLife

  eLife assessment

  This study presents valuable new insights from the protist Tetrahymena regarding radial spokes, conserved protein complexes that are relevant for cilia motility. The work employs interdisciplinary approaches to provide convincing support for radial spoke composition with some experiments, but there are weaker areas with partially incomplete support, such as relying on knockouts alone rather than including localization studies of tagged proteins.

Reviewed by eLife