Centriolar satellites are sites of translation of centrosomal and ciliary proteins
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Abstract
Centriolar satellites are cytoplasmic particles found in the vicinity of centrosomes and cilia whose functional contribution to the formation of these cellular structures has long been unclear. By characterizing the main scaffolding component of satellites, PCM1 or Combover in Drosophila , we show that satellites are not involved in cellular trafficking as previously thought but rather act as sites for the coordinate translation of centrosomal and ciliary proteins through the interaction with a set of RNA binding proteins and proteins involved in quality control. Strikingly, the concentration of satellites near centrosomes and cilia in vertebrates is not a conserved feature and therefore dispensable for satellite function. Such coordinate synthesis may be a general feature in eukaryotic cells to facilitate protein complex formation and cellular compartmentalization.
One-Sentence Summary
Centriolar satellites facilitate the coordinate synthesis of centrosomal and ciliary proteins.
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Super interesting results/model! Years ago, we saw nascent proteins near basal bodies (using a puromycin analog to label as well) in Chlamy, which doesn’t have a clear PCM-1 ortholog/centiolar satellites. So according to this, where there is protein synthesis at satellites whether they are (vertebrates) or are not (flies) near centrosomes/cilia, maybe there is different, satellite-free local protein synthesis at cilia/centrioles of a different pool of mRNAs. Or maybe your waystation hypothesis is correct rather than protein synthesis actually happening at satellites directly.
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