Cell Biology

Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia

1. Yoshinobu Ichimura
2. Yuki Sugiura
3. Yoshinori Katsuragi
4. Yu-Shin Sou
5. Takefumi Uemura
6. Naoki Tamura
7. Satoko Komatsu-Hirota
8. Takashi Ueno
9. Masato Koike
10. Satoshi Waguri
11. Masaaki Komatsu

• Curated by eLife

  eLife assessment

  This paper presents useful findings on the dysmyelination phenotype of nervous system-specific Spns1 (a lysosomal lipid transporter) knockout mice. While the analysis of the phenotype is solid, the evidence for the underlying mechanisms, especially the molecular function for SPNS1, is incomplete. With more careful interpretation and/or additional experimental data, this work could have implications for understanding lipid transport and lysosomal storage diseases.

Reviewed by eLife

The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

1. Liam C Hunt
2. Kudzai Nyamkondiwa
3. Anna Stephan
4. Jianqin Jiao
5. Kanisha Kavdia
6. Vishwajeeth Pagala
7. Junmin Peng
8. Fabio Demontis

• Curated by eLife

  eLife assessment

  This valuable study presents findings on the role of the ubiquitin-conjugating enzyme UBE2D/eff in maintaining proteostasis during aging. The evidence supporting the conclusions is solid, although one reviewer had concerns about the readout for protein aggregation and the loss-of-function studies. In the future, mechanistic insights explaining the impact of UBE2D/eff deficiency on the accumulation of poly-ubiquitinated proteins and in shortening lifespan would be interesting. The present study is of broad interest to cell biologists working in aging and age-related diseases.

Reviewed by eLife

Compartmentalized Cytoplasmic Flows Direct Protein Transport to the Cell’s Leading Edge

1. Catherine G. Galbraith
2. Brian P. English
3. Ulrike Boehm
4. James A. Galbraith

Reviewed by Arcadia Science

Phosphorylation of Aly3 C-terminus impedes aberrant endocytosis of S. pombe hexose transporter Ght5

1. Yusuke Toyoda
2. Fumie Masuda
3. Shigeaki Saitoh

Reviewed by Review Commons

The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis

1. Younis Hazari
2. Hery Urra
3. Valeria A. Garcia Lopez
4. Javier Diaz
5. Giovanni Tamburini
6. Mateus Milani
7. Philippe Pihan
8. Sylvere Durand
9. Fanny Aprahamia
10. Reese Baxter
11. Menghao Huang
12. X Charlie Dong
13. Helena Vihinen
14. Ana Batista-Gonzalez
15. Patricio Godoy
16. Alfredo Criollo
17. Vlad Ratziu
18. Fabienne Foufelle
19. Jan G. Hengstler
20. Eija Jokitalo
21. Beatrice Bailly-maitre
22. Jessica L Maiers
23. Lars Plate
24. Guido Kroemer
25. Claudio Hetz

Reviewed by Review Commons