Cell Biology

Cell contacts and pericellular matrix in the Xenopus gastrula chordamesoderm

1. Olivia Luu
2. Debanjan Barua
3. Rudolf Winklbauer

Reviewed by Review Commons

An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability

1. Joshua Okletey
2. Dimitrios Angelis
3. Tia M. Jones
4. Cristina Montagna
5. Elias T. Spiliotis

Reviewed by preLights

The Kelch13 compartment is a hub of highly divergent vesicle trafficking proteins in malaria parasites

1. Sabine Schmidt
2. Jan Stephan Wichers-Misterek
3. Hannah Michaela Behrens
4. Jakob Birnbaum
5. Isabelle G. Henshall
6. Jana Dröge
7. Ernst Jonscher
8. Sven Flemming
9. Carolina Castro-Peña
10. Paolo Mesén-Ramírez
11. Tobias Spielmann

Reviewed by Review Commons

A scalable, data analytics workflow for image-based morphological profiles

1. Edvin Forsgren
2. Olivier Cloarec
3. Pär Jonsson
4. Johan Trygg

Reviewed by Arcadia Science

Actin contraction controls nuclear blebbing and rupture independent of actin confinement

1. Mai Pho
2. Yasmin Berrada
3. Aachal Gunda
4. Anya Lavallee
5. Katherine Chiu
6. Arimita Padam
7. Marilena L. Currey
8. Andrew D. Stephens

Reviewed by Review Commons

SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis

1. Vanessa Goyon
2. Aurèle Besse-Patin
3. Rodolfo Zunino
4. Mai Nguyen
5. Étienne Coyaud
6. Jonathan M. Lee
7. Bich N. Nguyen
8. Brian Raught
9. Heidi M. McBride

Reviewed by Review Commons

Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans

1. Elisabeth Jongsma
2. Anita Goyala
3. José Maria Mateos
4. Collin Yvès Ewald

• Curated by eLife

  eLife assessment

  Using a newly developed C. elegans model of Alzheimer's disease that expresses Abeta aggregates extracellularly, the authors provide convincing evidence of a disintegrin and an ortholog of human ADAM9 that participate in removing these extracellular aggregates. The worm model presented in this important paper may be very useful to the Alzheimer Disease field.

Reviewed by eLife

The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

1. Maikel Castellano-Pozo
2. Georgios Sioutas
3. Consuelo Barroso
4. Josh P Prince
5. Pablo Lopez-Jimenez
6. Joseph Davy
7. Angel-Luis Jaso-Tamame
8. Oliver Crawley
9. Nan Shao
10. Jesus Page
11. Enrique Martinez-Perez

• Curated by eLife

  eLife assessment

  This important paper reveals distinct dynamics of two meiosis-specific cohesin complexes containing either REC-8 or CHO-3/4 in C. elegans: REC-8-cohesin is essential for sister chromatid cohesion in meiosis I and DNA double-strand break repair, while COH-3/4-cohesin, whose binding to meiotic chromosomes is stabilized by the cohesin accessory protein SCC-2, is necessary for loop-axis formation. The experimental evidence in the paper is solid based on cytological analysis using a conditional depletion of the gene. The work will be of interest to researchers working on meiosis and chromosome dynamics.

Reviewed by eLife

Centriole elimination during C. elegans oogenesis initiates with loss of the central tube protein SAS-1

1. Marie Pierron
2. Alexander Woglar
3. Coralie Busso
4. Keshav Jha
5. Tamara Mikeladze-Dvali
6. Marie Croisier
7. Pierre Gönczy

Reviewed by Review Commons

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

1. Avi J. Samelson
2. Nabeela Ariqat
3. Justin McKetney
4. Gita Rohanitazangi
5. Celeste Parra Bravo
6. Darrin Goodness
7. Ruilin Tian
8. Parker Grosjean
9. Romany Abskharon
10. David Eisenberg
11. Nicholas M. Kanaan
12. Li Gan
13. Carlo Condello
14. Danielle L. Swaney
15. Martin Kampmann

Reviewed by preLights