Cell Biology

O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control

1. Conor W. Mitchell
2. Huijie Yuan
3. Marie Sønderstrup-Jensen
4. Andrew T. Ferenbach
5. Daan M. F. van Aalten

Reviewed by Review Commons

Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components

1. Fani Roumelioti
2. Christos Tzaferis
3. Dimitris Konstantopoulos
4. Dimitra Papadopoulou
5. Alejandro Prados
6. Maria Sakkou
7. Anastasios Liakos
8. Panagiotis Chouvardas
9. Theodore Meletakos
10. Yiannis Pandis
11. Niki Karagianni
12. Maria C Denis
13. Maria Fousteri
14. Maria Armaka
15. George Kollias

• Curated by eLife

  eLife assessment

  This important manuscript used state-of-the-art techniques and employed relevant animal models to provide both convincing and solid evidence supporting the regulatory role of microRNA cluster 221/222 in rheumatoid arthritis synovial fibroblast. The findings of this work offer significant advances to current knowledge which will be interesting to a wide range audience in the rheumatology and bone research fields. However, whereas models, techniques, and analyses are solid, certain concepts related to the role of immune and bone cells are limited.

Reviewed by eLife

Nucleocytoplasmic transport senses mechanics independently of cell density in cell monolayers

1. Ignasi Granero-Moya
2. Guillaume Belthier
3. Bart Groenen
4. Marc Molina-Jordán
5. Miguel González-Martín
6. Xavier Trepat
7. Jacco van Rheenen
8. Ion Andreu
9. Pere Roca-Cusachs

Reviewed by Review Commons

G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics

1. Alexandra Mazharian
2. Ophélie Bertin
3. Amrita Sarkar
4. Johanna Augros
5. Alicia Bornert
6. Cécile Loubière
7. Friederike Jönsson
8. Juli Warwicker
9. W Mark Abbott
10. Omer Dushek
11. Caroline Vayne
12. Lubica Rauova
13. Klaus Fütterer
14. Jérôme Rollin
15. Mortimer Poncz
16. Yotis A Senis

Reviewed by preLights

Alstrom syndrome proteins regulate centriolar cartwheel assembly by enabling Plk4-Ana2 amplification loop in Drosophila

1. Marine Brunet
2. Joelle Thomas
3. Jean-Andre Lapart
4. Léo Krüttli
5. Marine Laporte
6. Maria Giovanna Riparbelli
7. Giuliano Callaini
8. Benedicte Durand
9. Veronique Morel

Reviewed by Review Commons

PILS-Nir1 is a novel phosphatidic acid biosensor that reveals mechanisms of lipid production

1. Claire C. Weckerly
2. Taylor A. Rahn
3. Max Ehrlich
4. Rachel C. Wills
5. Joshua G. Pemberton
6. Michael V. Airola
7. Gerald R. V. Hammond

Reviewed by Review Commons

Vacuolar H+-ATPase determines daughter cell fates through asymmetric segregation of the nucleosome remodeling and deacetylase complex

1. Zhongyun Xie
2. Yongping Chai
3. Zhiwen Zhu
4. Zijie Shen
5. Zhengyang Guo
6. Zhiguang Zhao
7. Long Xiao
8. Zhuo Du
9. Guangshuo Ou
10. Wei Li

• Curated by eLife

  eLife assessment

  The authors make the intriguing proposal that the NuRD complex in C. elegans, which has been linked to regulation of the cell death protein EGL-1 before, becomes asymmetrically distributed after cell division and that this asymmetry relies on V-ATPase activity. Whereas some disagreement remained between the reviewers' and the authors' interpretation, the final version incorporated alternative possibilities in the text, and with careful interpretation, the current manuscript's model is supported by solid data, and represents a valuable contribution to the field.

Reviewed by eLife

Growth-dependent concentration gradient of the oscillating Min system in Escherichia coli

1. Claudia Parada
2. Ching-Cher Sanders Yan
3. Cheng-Yu Hung
4. I-Ping Tu
5. Chao-Ping Hsu
6. Yu-Ling Shih

Reviewed by Review Commons

Time-resolved interactome profiling deconvolutes secretory protein quality control dynamics

1. Madison T Wright
2. Bibek Timalsina
3. Valeria Garcia Lopez
4. Jake N Hermanson
5. Sarah Garcia
6. Lars Plate

Reviewed by Review Commons

Differential regulation by CD47 and thrombospondin-1 of extramedullary erythropoiesis in mouse spleen

1. Rajdeep Banerjee
2. Thomas J Meyer
3. Margaret C Cam
4. Sukhbir Kaur
5. David D Roberts

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the cell composition in mouse spleen depleted for the CD47 receptor and its signaling ligand Thrombospondin in hematopoietic differentiation. The supporting evidence is convincing with analytical improvements on the individual contributions of the signaling components and with functional studies. This work has implications for the role of CD47/Thsp in extramedullary erythropoiesis in mouse spleen and will be of interest to medical biologists working on cell signaling, transfusion medicine, and cell therapy.

Reviewed by eLife