Cell Biology

Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

1. Ling-Yun Zhou
2. Chen-Xi Jin
3. Wen-Xiao Wang
4. Lei Song
5. Jung-Bum Shin
6. Ting-Ting Du
7. Hao Wu

• Curated by eLife

  eLife assessment

  This valuable study provides solid evidence implicating two transcription factors in the development of the actin cytoskeleton that shapes the mechanosensory hair bundles of the inner ear's hair cells. The work will be of interest to biologists interested in the development and maintenance of the hair bundle, both normal or impaired. Its impact would be improved by providing a mechanistic model for the observed effects.

Reviewed by eLife

Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity

1. Yong Yu
2. Shihong M Gao
3. Youchen Guan
4. Pei-Wen Hu
5. Qinghao Zhang
6. Jiaming Liu
7. Bentian Jing
8. Qian Zhao
9. David M Sabatini
10. Monther Abu-Remaileh
11. Sung Yun Jung
12. Meng C Wang

• Curated by eLife

  eLife assessment

  These authors present a powerful tool to unbiasedly identify lysosome-associated proteins in C. elegans, and they provide a compelling, in-depth assessment of how this method can be used to understand longevity pathways and identify novel proteins. Understanding lysosomal differences in specific tissues or in response to different longevity conditions are exciting as it provides new insight into how organelles could control specific homeostasis responses. This valuable tool and proteomics datasets also represent a great resource for the C. elegans community and should pry open new studies on the regulation and role of the lysosome at the organismal level.

Reviewed by eLife

Off-targets of BRAF inhibitors disrupt endothelial signaling and differentially affect vascular barrier function

1. Sophie Bromberger
2. Yuliia Zadorozhna
3. Julia Maria Ressler
4. Silvio Holzner
5. Arkadiusz Nawrocki
6. Nina Zila
7. Alexander Springer
8. Martin Røssel Larsen
9. Klaudia Schossleitner

Reviewed by Review Commons

Tunneling nanotubes enable intercellular transfer in zebrafish embryos

1. Olga Korenkova
2. Shiyu Liu
3. Inès Prlesi
4. Anna Pepe
5. Shahad Albadri
6. Filippo Del Bene
7. Chiara Zurzolo

Reviewed by Arcadia Science

Bsp1, a fungal CPI motif protein, regulates actin filament capping in endocytosis and cytokinesis

1. Daniel R. Hummel
2. Markku Hakala
3. Christopher P. Toret
4. Marko Kaksonen

Reviewed by Arcadia Science

A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression

1. David Salvador-Garcia
2. Li Jin
3. Andrew Hensley
4. Mert Gölcük
5. Emmanuel Gallaud
6. Sami Chaaban
7. Fillip Port
8. Alessio Vagnoni
9. Vicente José Planelles-Herrero
10. Mark A. McClintock
11. Emmanuel Derivery
12. Andrew P. Carter
13. Régis Giet
14. Mert Gür
15. Ahmet Yildiz
16. Simon L. Bullock

Reviewed by Review Commons

Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase

1. Léonard Colin
2. Celine Reyes
3. Julien Berthezene
4. Laetitia Maestroni
5. Laurent Modolo
6. Esther Toselli
7. Nicolas Chanard
8. Stephane Schaak
9. Olivier Cuvier
10. Yannick Gachet
11. Stephane Coulon
12. Pascal Bernard
13. Sylvie Tournier

• Curated by eLife

  eLife assessment

  This is an important study that characterises the involvement of condensin complexes in the segregation of telomeres in fission yeast. The authors present convincing evidence to support their claims, employing a diverse range of complementary techniques. This research will be of interest to cell biologists working on chromosome biology and cell division.

Reviewed by eLife

Systemic Lupus Erythematosus Serum Stimulation of Human Intestinal Organoids Induces Changes in Goblet Cell Differentiation and Mitochondrial Fitness

1. Inga Viktoria Hensel
2. Szabolcs Éliás
3. Michelle Steinhauer
4. Bilgenaz Stoll
5. Salvatore Benfatto
6. Wolfgang Merkt
7. Stefan Krienke
8. Hanns-Martin Lorenz
9. Jürgen Haas
10. Brigitte Wildeman
11. Martin Resnik-Docampo

Reviewed by Review Commons

Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI

1. Alexander Kapustin
2. Sofia Serena Tsakali
3. Meredith Whitehead
4. George Chennell
5. Meng-Ying Wu
6. Chris Molenaar
7. Anton Kutikhin
8. Leo Bogdanov
9. Maxim Sinitsky
10. Kseniya Rubina
11. Aled Clayton
12. Frederik J Verweij
13. Dirk Michiel Pegtel
14. Simona Zingaro
15. Arseniy Lobov
16. Bozhana Zainullina
17. Dylan Owen
18. Maddy Parsons
19. Richard E. Cheney
20. Derek Warren
21. Martin James Humphries
22. Thomas Iskratsch
23. Mark Holt
24. Catherine M Shanahan

• Curated by eLife

  eLife assessment

  This paper investigates the potential role of extracellular vesicles in providing extracellular matrix signals for migration of vascular smooth muscle cells. The findings could be useful for researchers interested in cell migration, but the evidence supporting the conclusions is presently incomplete.

Reviewed by eLife

Replisome loading reduces chromatin motion independent of DNA synthesis

1. Maruthi Kumar Pabba
2. Christian Ritter
3. Vadim O Chagin
4. Janis Meyer
5. Kerem Celikay
6. Jeffrey H Stear
7. Dinah Loerke
8. Ksenia Kolobynina
9. Paulina Prorok
10. Alice Kristin Schmid
11. Heinrich Leonhardt
12. Karl Rohr
13. M Cristina Cardoso

• Curated by eLife

  eLife assessment

  This is a valuable investigation of the chromatin dynamics throughout the cell cycle by using fluorescence signals and patterns of GFP-PCNA and CY3-dUTP, which labels newly synthesized DNA. The authors report reduced chromatin mobility in S relative to G1 phase. The technology and methods used are solid. The data will be of interest to researchers working on chromatin dynamics.

Reviewed by eLife