Cell Biology

A genetic and physiological model of renal dysfunction in Lowe syndrome

1. Navyashree A Ramesh
2. Vaishali Kataria
3. Indra Sara Lama
4. Rajan Thakur
5. Avishek Ghosh
6. Sanjeev Sharma
7. Aishwarya Venugopal
8. Anil Vasudevan
9. Raghu Padinjat

Reviewed by Review Commons

Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

1. KC Farrell
2. Jennifer T Wang
3. Tim Stearns

• Curated by eLife

  eLife assessment

  This work explores how centrosomes, which function as the primary microtubule organizing center in animal cells, regulate cell division by examining the process in cells in which centrosome formation has been inhibited. The carefully conducted experiments provide convincing support for the important observation that elongated, but successful, mitosis observed in cells lacking centrosomes is due to delays in cell cycle progression.

Reviewed by eLife

The transmembrane protein Syndecan regulates stem cell nuclear properties and cell maintenance

1. Buffy L. Eldridge-Thomas
2. Jerome G. Bohere
3. Chantal Roubinet
4. Alexandre Barthelemy
5. Tamsin J. Samuels
6. Felipe Karam Teixeira
7. Golnar Kolahgar

Reviewed by Review Commons

Mecp2 fine-tunes quiescence exit by targeting nuclear receptors

1. Jun Yang
2. Shitian Zou
3. Zeyou Qiu
4. Mingqiang Lai
5. Qing Long
6. Huan Chen
7. Ping lin Lai
8. Sheng Zhang
9. Zhi Rao
10. Xiaoling Xie
11. Yan Gong
12. Anling Liu
13. Mangmang Li
14. Xiaochun Bai

• Curated by eLife

  eLife assessment

  This fundamental study provides insights into the mechanism controlling cell cycle reentry, establishing a regulatory role for Mecp2 degradation in shifting transcription from metabolic to proliferation genes during quiescence exit. The evidence, which includes experimental data from in vitro cell culture and an in vivo injury-induced liver regeneration model, is convincing but the trigger for MeCP2 degradation and how MeCP2 differentially regulates proliferation and metabolic genes remain unclear.

Reviewed by eLife

IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat

1. Henver S. Brunetta
2. Anna S. Jung
3. Fernando Valdivieso-Rivera
4. Stepheny C. C. Zani
5. Joel Guerra
6. Vanessa Furino
7. Annelise Francisco
8. Marcelo Berçot
9. Pedro M. M. Moraes-Vieira
10. Susanne Keipert
11. Martin Jastroch
12. Laurent O. Martinez
13. Carlos H. Sponton
14. Roger F. Castilho
15. Marcelo A. Mori
16. Alexander Bartelt

Reviewed by Review Commons

eIF5A controls mitoprotein import by relieving ribosome stalling at the TIM50 translocase mRNA

1. Marina Barba-Aliaga
2. Vanessa Bernal
3. Cynthia Rong
4. Brian M. Zid
5. Paula Alepuz

Reviewed by Review Commons

Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation

1. Abhishek Kumar
2. Keiichiro Tanaka
3. Martin A Schwartz

• Curated by eLife

  eLife assessment

  In this valuable study, Kumar et al., provide evidence suggesting that the p130Cas drives the formation of condensates that sprout from focal adhesions to cytoplasm and suppress translation. Pending further substantiation, this study was found to be likely to provide previously unappreciated insights into the mechanisms linking focal adhesions to the regulation of protein synthesis and was thus considered to be of broad general interest. However, the evidence supporting the proposed model was incomplete; additional evidence is warranted to substantiate the relationship between p130Cas condensates and mRNA translation and establish corresponding functional consequences.

Reviewed by eLife

Patterning in stratified epithelia depends on cell–cell adhesion

1. Yosuke Mai
2. Yasuaki Kobayashi
3. Hiroyuki Kitahata
4. Takashi Seo
5. Takuma Nohara
6. Sota Itamoto
7. Shoko Mai
8. Junichi Kumamoto
9. Masaharu Nagayama
10. Wataru Nishie
11. Hideyuki Ujiie
12. Ken Natsuga

Reviewed by Review Commons

BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

1. Ruichen Yang
2. Hongshang Chu
3. Hua Yue
4. Yuji Mishina
5. Zhenlin Zhang
6. Huijuan Liu
7. Baojie Li

• Curated by eLife

  eLife assessment

  BMP signaling plays a vital role in skeletal tissues, and the importance of its role in microtia prevention is novel and promising. This important study sheds light on the role of BMP signaling in preventing microtia in the ear, with solid data broadly supporting the claims of the authors.

Reviewed by eLife

CRISPR screens and lectin microarrays identify high mannose N-glycan regulators

1. C. Kimberly Tsui
2. Nicholas Twells
3. Jenni Durieux
4. Emma Doan
5. Jacqueline Woo
6. Noosha Khosrojerdi
7. Janiya Brooks
8. Ayodeji Kulepa
9. Brant Webster
10. Lara K. Mahal
11. Andrew Dillin

Reviewed by Arcadia Science