Cell Biology

G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics

1. Alexandra Mazharian
2. Ophélie Bertin
3. Amrita Sarkar
4. Johanna Augros
5. Alicia Bornert
6. Cécile Loubière
7. Friederike Jönsson
8. Juli Warwicker
9. W Mark Abbott
10. Omer Dushek
11. Caroline Vayne
12. Lubica Rauova
13. Klaus Fütterer
14. Jérôme Rollin
15. Mortimer Poncz
16. Yotis A Senis

Reviewed by preLights

Alstrom syndrome proteins regulate centriolar cartwheel assembly by enabling Plk4-Ana2 amplification loop in Drosophila

1. Marine Brunet
2. Joelle Thomas
3. Jean-Andre Lapart
4. Léo Krüttli
5. Marine Laporte
6. Maria Giovanna Riparbelli
7. Giuliano Callaini
8. Benedicte Durand
9. Veronique Morel

Reviewed by Review Commons

PILS-Nir1 is a novel phosphatidic acid biosensor that reveals mechanisms of lipid production

1. Claire C. Weckerly
2. Taylor A. Rahn
3. Max Ehrlich
4. Rachel C. Wills
5. Joshua G. Pemberton
6. Michael V. Airola
7. Gerald R. V. Hammond

Reviewed by Review Commons

Vacuolar H+-ATPase determines daughter cell fates through asymmetric segregation of the nucleosome remodeling and deacetylase complex

1. Zhongyun Xie
2. Yongping Chai
3. Zhiwen Zhu
4. Zijie Shen
5. Zhengyang Guo
6. Zhiguang Zhao
7. Long Xiao
8. Zhuo Du
9. Guangshuo Ou
10. Wei Li

• Curated by eLife

  eLife assessment

  The authors make the intriguing proposal that the NuRD complex in C. elegans, which has been linked to regulation of the cell death protein EGL-1 before, becomes asymmetrically distributed after cell division and that this asymmetry relies on V-ATPase activity. Whereas some disagreement remained between the reviewers' and the authors' interpretation, the final version incorporated alternative possibilities in the text, and with careful interpretation, the current manuscript's model is supported by solid data, and represents a valuable contribution to the field.

Reviewed by eLife

Growth-dependent concentration gradient of the oscillating Min system in Escherichia coli

1. Claudia Parada
2. Ching-Cher Sanders Yan
3. Cheng-Yu Hung
4. I-Ping Tu
5. Chao-Ping Hsu
6. Yu-Ling Shih

Reviewed by Review Commons

Time-resolved interactome profiling deconvolutes secretory protein quality control dynamics

1. Madison T Wright
2. Bibek Timalsina
3. Valeria Garcia Lopez
4. Jake N Hermanson
5. Sarah Garcia
6. Lars Plate

Reviewed by Review Commons

Differential regulation by CD47 and thrombospondin-1 of extramedullary erythropoiesis in mouse spleen

1. Rajdeep Banerjee
2. Thomas J Meyer
3. Margaret C Cam
4. Sukhbir Kaur
5. David D Roberts

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the cell composition in mouse spleen depleted for the CD47 receptor and its signaling ligand Thrombospondin in hematopoietic differentiation. The supporting evidence is convincing with analytical improvements on the individual contributions of the signaling components and with functional studies. This work has implications for the role of CD47/Thsp in extramedullary erythropoiesis in mouse spleen and will be of interest to medical biologists working on cell signaling, transfusion medicine, and cell therapy.

Reviewed by eLife

Membrane lipid poly-unsaturation selectively affects ligand induced dopamine D2 receptor internalization

1. Silvia Sposini
2. Rim Baccouch
3. Mathias Lescuyer
4. Véronique De Smedt-Peyrusse
5. Joyce Heuninck
6. Thierry Durroux
7. Pierre Trifilieff
8. David Perrais
9. Isabel Alves

Reviewed by Review Commons

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects

1. Ritobrata Ghose
2. Fabio Pezzano
3. Savvas Kourtis
4. Ilir Sheraj
5. Shubhamay Das
6. Antoni Gañez Zapater
7. Upamanyu Ghose
8. Lorena Espinar
9. Katja Parapatics
10. Valeria Venturini
11. André C Müller
12. Verena Ruprecht
13. Sara Sdelci

Reviewed by preLights

Neutrophils actively swell to potentiate rapid migration

1. Tamas L Nagy
2. Evelyn Strickland
3. Orion D Weiner

• Curated by eLife

  eLife assessment

  This fundamental study significantly advances our understanding of the role of water influx and swelling on neutrophil migration in response to chemoattractant. The evidence supporting the conclusions, based on a genome-wide CRISPR screen and high quality cellular observations, is compelling. This paper will be of interest to cell biologists and biophysicists working on cell migration.

Reviewed by eLife