Cell Biology

The eduWOSM: a benchtop advanced microscope for education and research

1. Nicholas J Carter
2. Douglas S Martin
3. Justin E Molloy
4. Robert A Cross

• Curated by eLife

  eLife Assessment

  This is a valuable study and a promising development for the field of open-source microscopy for educational purposes. The strengths include the low cost of constructing the microscope, impressive performance and detailed resources including a dedicated website and YouTube channel. The claims are generally supported by solid evidence, however, the manuscript would be strengthened by inclusion of further details on standard performance metrics (e.g. signal to noise ratio etc.) compared to existing systems and further details and clarification on the microscope, construction and operation.

Reviewed by eLife

p53 engagement is a hallmark of an unfolded protein response in the nucleus of mammalian cells

1. Joseph H Park
2. Thomas J Wandless

• Curated by eLife

  eLife Assessment

  This paper presents useful findings that misfolded proteins in the nucleus can impair proteasomal degradation and activate p53. The results supporting the findings are largely solid, but incomplete. The manuscript could be strengthened by including more quantitative data analyses and additional experimentation/discussions on the mechanism of p53 activation by misfolded nuclear proteins. The work will be interesting primarily to scientists studying protein homeostasis.

Reviewed by eLife

Adenomatous polyposis coli (APC) regulates internalization and signaling of the chemorepellent receptor, Roundabout (ROBO) 1

1. Yi-Wei Huang
2. Jonathan St-Germain
3. Bo Wen Pang
4. Richard F Collins
5. Etienne Coyaud
6. Wenjuan Li
7. Amir Mohamed
8. Brian Raught
9. Sergio Grinstein
10. Lisa A Robinson

Reviewed by Review Commons

Holotomographic microscopy reveals label-free quantitative dynamics of endothelial cells during endothelialization

1. William D. Leineweber
2. Gabriela Acevedo Munares
3. Christian Leycam
4. Raul Michael
5. Juliette Noyer
6. Patrick Jurney

Reviewed by Arcadia Science

Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer

1. Jasmin Kaivola
2. Karolina Punovuori
3. Megan R. Chastney
4. Yekaterina A. Miroshnikova
5. Hind Abdo
6. Fabien Bertillot
7. Fabian Krautgasser
8. Jasmin Di Franco
9. James R.W. Conway
10. Gautier Follain
11. Jaana Hagström
12. Antti Mäkitie
13. Heikki Irjala
14. Sami Ventelä
15. Hellyeh Hamidi
16. Giorgio Scita
17. Roberto Cerbino
18. Sara A. Wickström
19. Johanna Ivaska

Reviewed by preLights

A FUCCI sensor reveals complex cell cycle organization of Toxoplasma endodyogeny

1. Mrinalini Batra
2. Clem Marsilia
3. Danya Awshah
4. Lauren M. Hawkins
5. Chengqi Wang
6. Dale Chaput
7. Daria A. Naumova
8. Elena S. Suvorova

Reviewed by Review Commons