Cell Biology

Immunosuppression Drugs Exhibit Differential Effects on Endothelial Cell Function

1. Aly Elezaby
2. Ryan Dexheimer
3. David Wu
4. Sze Yu Chan
5. Ines Ross Tacco
6. Ian Y. Chen
7. Nazish Sayed
8. Karim Sallam

Reviewed by PREreview

Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

1. Ryosuke Isotani
2. Masaki Igarashi
3. Masaomi Miura
4. Kyoko Naruse
5. Satoshi Kuranami
6. Manami Katoh
7. Seitaro Nomura
8. Toshimasa Yamauchi

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal stem cell growth and tumorigenesis. The evidence supporting the claims of the authors is solid. This research will be of interest to medical biologists specializing in intestinal tumors.

Reviewed by eLife

RGG motif-containing Scd6/LSM14A proteins regulate the translation of specific mRNAs in response to hydroxyurea-induced genotoxic stress

1. Gayatri Mohanan
2. Raju Roy
3. Hélène Malka-Mahieu
4. Swati Lamba
5. Lucilla Fabbri
6. Anusmita Biswas
7. Sylvain Martineau
8. Céline M. Labbé
9. Stéphan Vagner
10. Purusharth I Rajyaguru

Reviewed by Review Commons

Pin4 Links Post-transcriptional and Transcriptional Responses to Energy Depletion in Yeast

1. Michaela Ristová
2. Katherine Bexley
3. Johanna Franziska Seidler
4. Vadim Shchepachev
5. Sushma Sharma
6. Andrei Chabes
7. Atlanta G. Cook
8. David Tollervey

Reviewed by Arcadia Science

Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

1. Breanna Lam
2. Kathrin M Kajderowicz
3. Heather R Keys
4. Julian M Roessler
5. Evgeni M Frenkel
6. Adina Kirkland
7. Punam Bisht
8. Mohamed A El-Brolosy
9. Rudolf Jaenisch
10. George W Bell
11. Jonathan S Weissman
12. Eric C Griffith
13. Sinisa Hrvatin

• Curated by eLife

  eLife Assessment

  This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The evidence supporting these conclusions is compelling, combining multi-species CRISPR screening with rigorous pharmacological assays. This work will be of significant interest to biologists studying hibernation physiology and medical researchers interested in cold tolerance.

Reviewed by eLife

MDC1 mediates Pellino recruitment to sites of DNA double-strand breaks

1. Mònica Torres Esteban
2. Matthew J Stewart
3. Eilis Bragginton
4. Alice Meroni
5. Annica Pellizzari
6. Alain Jeanrenaud
7. Stephen J Smerdon
8. Manuel Stucki

Reviewed by Review Commons

miRNA-29-CLIP uncovers new targets and functions to improve skin repair

1. Lalitha Thiagarajan
2. Rosa Sanchez-Alvarez
3. Chiho Kambara
4. Poojitha Rajasekar
5. Yuluang Wang
6. Francois Halloy
7. Jonathan Hall
8. Hans-Juergen Stark
9. Iris Martin
10. Petra Boukamp
11. Svitlana Kurinna

Reviewed by Review Commons

Osterix Facilitates Osteocytic Communication by Targeting Connexin43

1. Zuping Wu
2. Qian Chen
3. Qian Gao
4. Muchun Liang
5. Yumeng Zhou
6. Li Zhu
7. Jiahe Wang
8. Yang Shen
9. Junjun Jing
10. Jing Xie
11. Xiaoheng Liu
12. Shujuan Zou
13. Demao Zhang
14. Chenchen Zhou

• Curated by eLife

  eLife Assessment

  This study offers valuable insights into the molecular mechanisms by which Osx influences osteocyte function, particularly through its regulation of Cx43. However, the evidence supporting the authors' claims is incomplete, necessitating additional experimental data and further investigation to fully substantiate these findings. While this study presents a new perspective on the complex role of Osx in bone biology, it also raises significant questions about the intricacies of its regulatory network.

Reviewed by eLife

Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress

1. Showkat Ahmad Dar
2. Sulochan Malla
3. Vlastimil Martinek
4. Matthew John Payea
5. Christopher Tai-Yi Lee
6. Jessica Martin
7. Aditya Jignesh Khandeshi
8. Jennifer L Martindale
9. Cedric Belair
10. Manolis Maragkakis

• Curated by eLife

  eLife Assessment

  This important study describes mRNA shortening during cellular stress and interestingly observes that this shortening is dependent on localization in stress granules. Surprisingly, this mRNA shortening does not appear to require the shortening of poly A tails. These are novel, paradigm-shifting findings, using cutting-edge technologies and convincing data, that should be of broad interest to the RNA community and beyond.

Reviewed by eLife, PREreview

MED26-enriched condensates drive erythropoiesis through modulating transcription pausing

1. Shicong Zhu
2. Xiaoting Zhang
3. Na Li
4. Xinying Zhao
5. Man Li
6. Si Xie
7. Qiuyu Yue
8. Yunfeng Li
9. Dong Li
10. Fan Wu
11. Zile Zhang
12. Ziqi Feng
13. Yiyang Zhang
14. Wonhyung Choi
15. Xinyi Jia
16. Yuelin Deng
17. Qi Hu
18. Xingyun Yao
19. Xiaofei Gao
20. Hsiang-Ying Lee

• Curated by eLife

  eLife Assessment

  The study is important to show the role of MED26 in red cell formation. Linking transcription pausing with erythropoiesis is a key discovery. The data are solid although there are still spaces to improve. The in vivo data are limited by specificity concerns on their Cre model. Having RNA-seq, using more erythroid markers such as band3 and a4-integrin, and orthogonal validation with iPSC-erythropoiesis model will improve the study.

Reviewed by eLife