Cell Biology

Spatial confinement induces reciprocating migration of epidermal keratinocytes and forms triphasic epithelia

1. Takuma Nohara
2. Junichi Kumamoto
3. Yosuke Mai
4. Mayuna Shimano
5. Sora Kato
6. Hiroyuki Kitahata
7. Hideki Nakamura
8. Shota Takashima
9. Mika Watanabe
10. Masaharu Nagayama
11. Tsukasa Oikawa
12. Hideyuki Ujiie
13. Ken Natsuga

• Curated by eLife

  eLife Assessment

  In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and subsequent mesenchymal-to-epithelial transition (MET) while migrating through a membrane with 3.0-µm micropores, and, thus, provides a valuable tool to study EMT and possibly wound regeneration or metastasis. Furthermore, a set of experiments provides solid data suggesting that TGF beta signaling and actin polymerization promote movement of epithelial cells into the pores, while Piezo1 and Keratin 6 prevent keratinocyte migration and EMT.

Reviewed by eLife

Roles of Srs2/PARI-family DNA helicases in NoCut checkpoint signaling and abscission regulation

1. Monica Dam
2. David F. Moreno
3. Nicola Brownlow
4. Audrey Furst
5. Coralie Spiegelhalter
6. Manuel Mendoza

Reviewed by Review Commons

A cryo-electron microscopy structure of yeast Pex5 in complex with a cargo uncovers a novel binding interface

1. Lior Peer
2. Orly Dym
3. Nadav Elad
4. Asa Tirosh
5. Jossef Jacobovitch
6. Ehud Sivan
7. Mor Angel
8. Shira Albeck
9. Maya Schuldiner
10. Yoav Peleg
11. Einat Zalckvar

Reviewed by Review Commons

Non-muscle myosin II regulates presynaptic actin assemblies and neuronal mechanobiology in Drosophila

1. Biljana Ermanoska
2. Jonathan Baets
3. Avital A. Rodal

Reviewed by Review Commons