Cell Biology

Mild mitochondrial impairment enhances innate immunity and longevity through ATFS‐1 and p38 signaling

1. Juliane C Campos
2. Ziyun Wu
3. Paige D Rudich
4. Sonja K Soo
5. Meeta Mistry
6. Julio CB Ferreira
7. T Keith Blackwell
8. Jeremy M Van Raamsdonk

Reviewed by Review Commons

Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia

1. Haoyang Wu
2. Peiyuan Lv
3. Jinyu Wang
4. Brian Bennett
5. Jiajia Wang
6. Pishun Li
7. Yi Peng
8. Guang Hu
9. Jiaji Lin

• Curated by eLife

  eLife assessment

  The authors performed a useful RNAi screen to identify epigenetic regulators involved in oxygen-glucose deprivation (OGD)-induced neuronal injury. PRMT5 was identified as a negative regulator of neuronal cell survival after OGD. Solid in vitro and in vivo data suggest that PRMT5 could be a novel therapeutic target for the treatment of ischemic stroke.

Reviewed by eLife

Apoptosis recognition receptors regulate skin tissue repair in mice

1. Olivia Justynski
2. Kate Bridges
3. Will Krause
4. Maria Fernanda Forni
5. Quan M Phan
6. Teresa Sandoval-Schaefer
7. Kristyn Carter
8. Diane E King
9. Henry C Hsia
10. Michael I Gazes
11. Steven D Vyce
12. Ryan R Driskell
13. Kathryn Miller-Jensen
14. Valerie Horsley

• Curated by eLife

  eLife assessment

  The authors studied the mechanisms by which dead cells are removed from the wounded skin in a process called efferocytosis. By analyzing different cell populations in the skin, the authors find that proteins involved in mediating the cell death and marking the cells as undergoing this process are elevated during distinct times in the wound healing program. Interestingly, these same proteins are elevated even higher in diabetic wounds. Finally the authors demonstrate that blocking the process of efferocytosis alters the wound healing program, thus illustrating its importance in effective wound repair.

Reviewed by eLife

Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms

1. Yeyun Ouyang
2. Mi-Young Jeong
3. Corey N Cunningham
4. Jordan A Berg
5. Ashish G Toshniwal
6. Casey E Hughes
7. Kristina Seiler
8. Jonathan G Van Vranken
9. Ahmad A Cluntun
10. Geanette Lam
11. Jacob M Winter
12. Emel Akdogan
13. Katja K Dove
14. Sara M Nowinski
15. Matthew West
16. Greg Odorizzi
17. Steven P Gygi
18. Cory D Dunn
19. Dennis R Winge
20. Jared Rutter

• Curated by eLife

  eLife assessment

  This study presents important findings on the regulation of the phosphate export cycle and identify the phosphatase Sit4 as a crucial player in regulation of the inner membrane potential of mitochondria. Whereas some of the data are convincing, the analyses will profit from deeper insights concerning metabolism alterations (carbon sources, amino acids). The major strength however is a new insight on how the cells use alternative ways for maintaining a critical mitochondrial inner membrane potential, and therefore this study is interesting to the broad audience with interests spanning from bioenergetics, metabolism and organellar and cell biology.

Reviewed by eLife

Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection

1. Emily G. Armbruster
2. Jina Lee
3. Joshua Hutchings
4. Arica R. VanderWal
5. Eray Enustun
6. Benja-min A. Adler
7. Ann Aindow
8. Amar Deep
9. Zaida K. Rodriguez
10. Chase J. Morgan
11. Majid Ghassemian
12. Emeric Charles
13. Brady F. Cress
14. David F. Savage
15. Jennifer A. Doudna
16. Kit Pogliano
17. Kevin D. Corbett
18. Elizabeth Villa
19. Joe Pogliano

Reviewed by Rapid Reviews Infectious Diseases, Arcadia Science

N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters

1. Anshuman Bhanja
2. Margaret K Seeley-Fallen
3. Michelle Lazzaro
4. Arpita Upadhyaya
5. Wenxia Song

• Curated by eLife

  eLife assessment

  This is an important study highlighting a distinct role of WASP dependent actin foci in B cell antigen receptor signalling. The evidence supporting the conclusions is compelling. The proposal of higher molecular density in B cell receptor clustering leading to kinase exclusion and attenuated signalling is provocative as it contrasts with models for other antigen receptors.

Reviewed by eLife

Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

1. Samarpan Maiti
2. Kaushik Bhattacharya
3. Diana Wider
4. Dina Hany
5. Olesya Panasenko
6. Lilia Bernasconi
7. Nicolas Hulo
8. Didier Picard

• Curated by eLife

  eLife assessment

  This important study describes the coordinated regulation of cellular size and protein translation in response to chronic stress as an adaptive mechanism, termed the 'rewiring stress response' regulated by the heat shock response. The evidence supporting this conclusion is solid, utilizing diverse methods to monitor and manipulate cell size and evaluate stress resistance. The study could be strengthened by the inclusion of more experiments focused on defining the mechanistic basis of this coordination and broadening the scope of the specific role of the 'rewiring stress response' across different chronic cellular stresses. This work will be of broad interest to researchers interested in diverse fields including cellular proteostasis, stress-responsive signaling, and aging and senescence.

Reviewed by eLife

Active compensation for changes in TDH3 expression mediated by direct regulators of TDH3 in Saccharomyces cerevisiae

1. Pétra Vande Zande
2. Mohammad A. Siddiq
3. Andrea Hodgins-Davis
4. Lisa Kim
5. Patricia J. Wittkopp

Reviewed by Review Commons

Asymmetric tethering by exocyst in vitro requires a Rab GTPase, a v-SNARE and a Sac1-sensitive phosphoinositide lipid

1. Guendalina Rossi
2. Gabrielle C. Puller
3. Patrick Brennwald

Reviewed by PREreview

Optineurin provides a mitophagy contact site for TBK1 activation

1. Koji Yamano
2. Momoha Sawada
3. Reika Kikuchi
4. Kafu Nagataki
5. Waka Kojima
6. Ryu Endo
7. Hiroki Kinefuchi
8. Atsushi Sugihara
9. Tomoshige Fujino
10. Aiko Watanabe
11. Keiji Tanaka
12. Gosuke Hayashi
13. Hiroshi Murakami
14. Noriyuki Matsuda

Reviewed by Review Commons