Cell Biology

  1. Detection of TurboID fusion proteins by fluorescent streptavidin outcompetes antibody signals and visualises targets not accessible to antibodies

    1. Johanna Odenwald
    2. Bernardo Gabiatti
    3. Silke Braune
    4. Siqi Shen
    5. Martin Zoltner
    6. Susanne Kramer

    • Curated by eLife

      eLife assessment

      This valuable study demonstrates how proximity labeling with streptavidin can be used to boost fluorescence signals in otherwise hard-to-label regions of cells. The experimental verification of amplification of fluorescence near epitope tags in phase-separated compartments is solid, demonstrating enhanced signal-to-noise compared to immunofluorescence. This study will be of particular interest to those using correlative light and electron microscopy or expansion microscopy when the signal is limiting or inaccessible.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  2. Membrane Curvature Promotes ER-PM Contact Formation via Junctophilin-EHD Interactions

    1. Yang Yang
    2. Luis A. Valencia
    3. Chih-Hao Lu
    4. Melissa L. Nakamoto
    5. Ching-Ting Tsai
    6. Chun Liu
    7. Huaxiao Yang
    8. Wei Zhang
    9. Zeinab Jahed
    10. Wan-Ru Lee
    11. Francesca Santoro
    12. Jen Liou
    13. Joseph C. Wu
    14. Bianxiao Cui

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Distinct trafficking routes of polarized and non-polarized membrane cargoes in Aspergillus nidulans

    1. Georgia Maria Sagia
    2. Xenia Georgiou
    3. Georgios Chamilos
    4. George Diallinas
    5. Sofia Dimou

    Reviewed by Review Commons

    5 evaluationsAppears in 1 listLatest version Latest activity

  4. Mitochondrial Apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways

    1. Melissa Lubeck
    2. Ritam Naha
    3. Yulia Schaumkessel
    4. Philipp Westhoff
    5. Anja Stefanski
    6. Patrick Petzsch
    7. Kai Stühler
    8. Karl Köhrer
    9. Andreas P. M. Weber
    10. Ruchika Anand
    11. Andreas S. Reichert
    12. Arun Kumar Kondadi

    Reviewed by Review Commons

    3 evaluationsAppears in 1 listLatest version Latest activity

  5. Atlas of Fshr expression from novel reporter mice

    1. Hongqian Chen
    2. Hui-Qing Fang
    3. Jin-Tao Liu
    4. Shi-Yu Chang
    5. Li-Ben Cheng
    6. Ming-Xin Sun
    7. Jian-Rui Feng
    8. Ze-Min Liu
    9. Yong-Hong Zhang
    10. Clifford J Rosen
    11. Peng Liu

    • Curated by eLife

      eLife assessment

      These valuable findings develop a mouse model with trackable fusion Fshr protein, which will be of use to the field. The animal model helps to elucidate the expression and function of the FSH receptor in extra-gonadal tissues. The strength of the evidence is solid in most parts, although additional validation of the localization data would strengthen the study considerably.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  6. Cytosolic and endoplasmic reticulum chaperones inhibit wt-p53 to increase cancer cells' survival by refluxing ER-proteins to the cytosol

    1. Salam Dabsan
    2. Gali Zur
    3. Naim Abu-Freha
    4. Shahar Sofer
    5. Iris Grossman-Haham
    6. Ayelet Gilad
    7. Aeid Igbaria

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. Mechanisms of cilia regeneration in Xenopus multiciliated epithelium in vivo

    1. Venkatramanan G. Rao
    2. Vignesharavind Subramanianbalachandar
    3. Magdalena M. Magaj
    4. Stefanie Redemann
    5. Saurabh S. Kulkarni

    Reviewed by Review Commons, Arcadia Science

    5 evaluationsAppears in 2 listsLatest version Latest activity

  8. Actin dynamics sustains spatial gradients of membrane tension in adherent cells

    1. Juan Manuel García-Arcos
    2. Amine Mehidi
    3. Julissa Sánchez Velázquez
    4. Pau Guillamat
    5. Caterina Tomba
    6. Laura Houzet
    7. Laura Capolupo
    8. Giovanni D’Angelo
    9. Adai Colom
    10. Elizabeth Hinde
    11. Charlotte Aumeier
    12. Aurélien Roux

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

    1. Roberto Notario Manzano
    2. Thibault Chaze
    3. Eric Rubinstein
    4. Esthel Penard
    5. Mariette Matondo
    6. Chiara Zurzolo
    7. Christel Brou

    • Curated by eLife

      eLife assessment

      Notario Manzano et al. offer a valuable first analysis of proteins within tunneling nanotubes (TNTs), membranous bridges connecting cells. This work distinguishes TNTs from extracellular vesicles, but further experimental and analytical tools are needed to refine the TNT proteome. Solid data supports a role for tetraspanins CD9 and CD81 in TNT function. The proposed model for CD9 and CD81 is over-interpreted and requires additional evidence for stronger support.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  10. Ca 2+ binding to Esyt is required to modulate membrane contact site density in Drosophila photoreceptors

    1. Vaisaly R Nath
    2. Harini Krishnan
    3. Shirish Mishra
    4. Padinjat Raghu

    Reviewed by Review Commons

    5 evaluationsAppears in 1 listLatest version Latest activity
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