Cell Biology

Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation

1. Shiqiang Xu
2. Alix Buridant
3. Thibault Hirsch
4. Massiullah Shafaq-Zadah
5. Estelle Dransart
6. Benjamin Ledoux
7. Ludger Johannes
8. Pierre van der Bruggen
9. Pierre Morsomme
10. Henri-François Renard

• Curated by eLife

  eLife Assessment

  This valuable study provides convincing evidence that specific proteins on the surface of cancer cells undergo a particular form of recycling and are redirected toward the cell-cell contact with T cells, a type of immune cell. However, the characterization of the consequences of T cell activation resulting from perturbing the recycling pathway is incomplete. Furthermore, relevant literature has not been sufficiently cited.

Reviewed by eLife

Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors

1. Weihua Wang
2. Junqiao Xing
3. Xiqi Zhang
4. Hongni Liu
5. Xingyu Liu
6. Haochen Jiang
7. Cheng Xu
8. Xue Zhao
9. Zhangfeng Hu

• Curated by eLife

  eLife Assessment

  This valuable study presents data suggesting the critical roles of two ancient proteins, XAP5 and XAP5L, in regulating the transcriptional program of ciliogenesis during mouse spermatogenesis. The supporting data are solid, and this work will be of interest to biomedical researchers studying ciliogenesis and reproduction.

Reviewed by eLife

Multi-omics analyses and machine learning prediction of oviductal responses in the presence of gametes and embryos

1. Ryan M Finnerty
2. Daniel J Carulli
3. Akshata Hedge
4. Yanli Wang
5. Frimpong Boadu
6. Sarayut Winuthayanon
7. Jianlin Jack Cheng
8. Wipawee Winuthayanon

• Curated by eLife

  eLife Assessment

  This important study reports the transcriptomic and proteomic landscapes of the oviducts at four different preimplantation stages during natural fertilization, pseudopregnancy, and superovulation. The supporting data are convincing. This work will be of interest to reproductive biologists and clinicians practicing reproductive medicine.

Reviewed by eLife

Quantification of Cyclin-CDK dissociation constants in living cells using fluorescence cross-correlation spectroscopy with green and near-infrared fluorescent proteins

1. Aika Toyama
2. Yuhei Goto
3. Yuhei Yamauchi
4. Hironori Sugiyama
5. Yohei Kondo
6. Atsushi Mochizuki
7. Kazuhiro Aoki

Reviewed by Review Commons

Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model

1. Mohammad E Torki
2. Fan Liu
3. Rongguang Xu
4. Yunfeng Chen
5. Jeffery Fredberg
6. Zi Chen

• Curated by eLife

  eLife Assessment

  This study presents a valuable nonlinear mathematical model that addresses how cell shape transitions in response to ECM stiffness. The evidence supporting the claims of the authors is solid, although additional work is required to improve the manuscript. For instance, the authors should improve the overall readability of the text and amend the experimental validation section. The work will be of interest to scientists working on a spectrum of fields including cell mechanics, cell behaviors, and cancer research.

Reviewed by eLife

Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons

1. Klaudia Strucinska
2. Parker Kneis
3. Travis Pennington
4. Katarzyna Cizio
5. Patrycja Szybowska
6. Abigail Morgan
7. Joshua Weertman
8. Tommy L Lewis

Reviewed by preLights

SRS microscopy identifies inhibition of vitellogenesis as a mediator of lifespan extension by caloric restriction in C. elegans

1. Bowen Yang
2. Bryce Manifold
3. Wuji Han
4. Catherin DeSousa
5. Wanyi Zhu
6. Aaron Streets
7. Denis V. Titov

Reviewed by Arcadia Science

MuSpAn: A Toolbox for Multiscale Spatial Analysis

1. Joshua A. Bull
2. Joshua W. Moore
3. Shania M. Corry
4. Muyang Lin
5. Hayley L. Belnoue-Davis
6. Eoghan J. Mulholland-Illingworth
7. Simon J. Leedham
8. Helen M. Byrne

Reviewed by Arcadia Science

Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

1. Laura Childers
2. Jieun Park
3. Siyao Wang
4. Richard Liu
5. Robert Barry
6. Stephen A Watts
7. John F Rawls
8. Michel Bagnat

• Curated by eLife

  eLife Assessment

  In this study, the authors use the zebrafish to investigate how the microbiome affects a specialized gut cell called the lysosome rich enterocyte. They use a combination of functional assays for protein absorption, gnotobiotic manipulations and single-cell RNA-seq. The findings in the paper are considered important and the results are convincing.

Reviewed by eLife

RAB18 Orchestrates Signaling Protein Ciliary Homeostasis by Facilitating BBSome Diffusion through the Transition Zone for Ciliary Entry

1. Wei-Yue Sun
2. Jingchao Zhang
3. Yan Wei
4. Linda S. Zhao
5. Zhen-Chuan Fan

Reviewed by Arcadia Science